de Franchis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53:762–768.
Iwakiri Y, Trebicka J. Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy. JHEP Rep. 2021;3:100316.
PubMed PubMed Central Google Scholar
Bosch J, Abraldes JG, Berzigotti A, García-Pagan JC. The clinical use of HVPG measurements in chronic liver disease. Nat Rev Gastroenterol Hepatol. 2009;6:573–582.
de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Baveno VII Faculty. Baveno VII—renewing consensus in portal hypertension. J Hepatol. 2022;76:959–974.
Karagiannakis DS, Karakousis ND, Androutsakos T. B-blockers in liver cirrhosis: a wonder drug for every stage of portal hypertension? A narrative review. Biomedicines 2024;12:57.
Laleman W, Nevens F. Cirrhotic portal hypertension: current and future medical therapy for primary and secondary prevention of variceal bleeding. Minerva Med. 2006;97:325–345.
Karagiannakis DS, Stefanaki K. Spleen stiffness: a predictive factor of dismal prognosis in liver cirrhosis. Clin J Gastroenterol. 2023;16:121–129.
PubMed PubMed Central Google Scholar
Karagiannakis DS, Voulgaris T, Siakavellas SI, Papatheodoridis GV, Vlachogiannakos. Evaluation of portal hypertension in the cirrhotic patient: hepatic vein pressure gradient and beyond. J. Scand J. Gastroenterol. 2018;53:1153–1164.
Karagiannakis DS, Markakis G, Lekakis V. Evaluation of spleen stiffness by 2D shear wave elastography for ruling out high-risk varices in patients with chronic advanced liver disease. A systematic review and meta-analysis. Eur J Radiol. 2024;175:111475.
Marasco G, Dajti E, Ravaioli F, Alemanni LV, Capuano F, Gjini K et al. Spleen stiffness measurement for assessing the response to β-blockers therapy for high-risk esophageal variceal patients. Hepatol Int. 2020;14:850–857.
Kim HY, So YH, Kim W, Ahn DW, Jung YJ, Woo H et al. Non-invasive response prediction in prophylactic carvedilol therapy for cirrhotic patients with esophageal varices. J Hepatol. 2019;70:412–422.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
PubMed PubMed Central Google Scholar
Schiavo JH. PROSPERO: an international register of systematic review protocols. Med Ref Serv Q 2019;38:171–180.
Bakbergenuly I, Kulinskaya E. Meta-analysis of binary outcomes via generalized linear mixed models: a simulation study. BMC Med Res Methodol. 2018;18:70.
PubMed PubMed Central Google Scholar
Akong’oOrawo L. Confidence intervals for the binomial proportion: a comparison of four methods. Open J Stat. 2021;11:806–816.
Dettori JR, Norvell DC, Chapman JR. Fixed-effect vs random-effects models for meta-analysis: 3 points to consider. Glob Spine J. 2022;12:1624–1626.
Freeman SC, Fisher D, White IR, Auperin A, Carpenter JR. Identifying inconsistency in network meta-analysis: Is the net heat plot a reliable method? Stat. Med. 2019;38:5547–5564.
PubMed PubMed Central Google Scholar
IntHout J, Ioannidis JP, Rovers MM, Goeman JJ. Plea for routinely presenting prediction intervals in meta-analysis. BMJ Open. 2016;6:e010247.
PubMed PubMed Central Google Scholar
Reitsma JB, Glas AS, Rutjes AW, Scholten RJ, Bossuyt PM, Zwinderman AH. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol. 2005;58:982–990.
R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2020.Available from: http://www.r-project.org/index.html Accessed 25 Jan 2021
Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–634.
PubMed PubMed Central Google Scholar
Reiberger T, Ferlitsch A, Payer BA, Pinter M, Homoncik M, Peck-Radosavljevic M et al. Non-selective b-blockers improve the correlation of liver stiffness and portal pressure in advanced cirrhosis. J Gastroenterol. 2012;47:561–568.
Piyachaturawat P, Siramolpiwat S, Sonsiri K, Tangkijvanich P, Treeprasertsuk S. Changes in transient elastography in early cirrhotic patients after receiving nonselective B-blocker for primary variceal bleeding prophylaxis: three-month follow-up. JGH Open. 2018;2:172–177.
PubMed PubMed Central Google Scholar
Zaghloul SG, Wahab EA, Seleem WM, Hanafy AS, Gomaa AF, Lakouz K et al. Impact of non-selective beta-blockers on portal hypertension and hepatic elasticity in hepatitis C virus-related liver cirrhosis. Drug Discov Ther. 2019;13:108–113.
Choi SY, Jeong WK, Kim Y, Kim J, Kim TY, Sohn JH. Shear-wave elastography: a noninvasive tool for monitoring changing hepatic venous pressure gradients in patients with cirrhosis. Radiology. 2014;273:917–26.
Zhang Y, Mao DF, Zhang MW, Fan XX. Clinical value of liver and spleen shear wave velocity in predicting the prognosis of patients with portal hypertension. World J Gastroenterol. 2017;23:8044–8052.
PubMed PubMed Central Google Scholar
Piecha F, Mandorfer M, Peccerella T, Ozga AK, Poth T, Vonbank A et al. Pharmacological decrease of liver stiffness is pressure-related and predicts long-term clinical outcomes. Am J Physiol Gastrointest Liver Physiol. 2018;315:G484–G494.
Binzberger A, Hänle M, Pfahler M, Kratzer W, Seufferlein T, Zizer E. Spleen and liver stiffness evaluation by arfi imaging: a reliable tool for a short-term monitoring of portal hypertension? Int J Hepatol. 2022;2022:7384144.
PubMed PubMed Central Google Scholar
Llop E, Perelló C, Fontanilla T, de la Revilla J, Conde MH, López M et al. Spleen transient elastography and damping index identify a subgroup of patients without an acute or chronic response to beta-blockers. Front Med (Lausanne). 2022;9:900073.
PubMed PubMed Central Google Scholar
Giuffrè M, Dupont J, Visintin A, Masutti F, Monica F, You K et al. Predicting response to non-selective beta-blockers with liver-spleen stiffness and heart rate in patients with liver cirrhosis and high-risk varices. Hepatol Int. 2024. https://doi.org/10.1007/s12072-024-10649-7.
Danielsen KV, Hove JD, Nabilou P, Yin M, Chen J, Zhao M et al. Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis. Liver Int. 2021;41:2149–2158.
PubMed PubMed Central Google Scholar
Jindal A, Sarin SK, Kumar M, Kumar G. Clinical outcomes in patients with advanced chronic liver disease and hepatic venous pressure gradient ≤ 10 mm Hg. Dig Dis Sci. 2022;67:5280–5289.
Mandorfer M, Abraldes JG, Berzigotti A. Non-invasive assessment of portal hypertension: Liver stiffness and beyond. JHEP Reports, 2024. 101300, ISSN 2589-5559.
Petta S, Sebastiani G, Viganò M, Ampuero J, Wai-Sun Wong V, Boursier J et al. Monitoring occurrence of liver-related events and survival by transient elastography in patients with nonalcoholic fatty liver disease and compensated advanced chronic liver disease. Clin Gastroenterol Hepatol. 2021;19:806-815.e5.
Lin H, Lee HW, Yip TC, Tsochatzis E, Petta S, Bugianesi E et al. Vibration-controlled transient elastography scores to predict liver-related events in steatotic liver disease. JAMA. 2024;331:1287–1297.
PubMed PubMed Central Google Scholar
Karagiannakis DS, Voulgaris T, Koureta E, Chloupi E, Papatheodoridis GV, Vlachogiannakos J. Role of spleen stiffness measurement by 2D-shear wave elastography in ruling out the presence of high-risk varices in cirrhotic patients. Dig Dis Sci. 2019;64:2653–2660.
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