Opportunities to Optimize Outcomes of Diagnosis and Treatment of HIV and Syphilis in Pregnancy: the Quest to Eliminate Maternal and Vertical Transmission

World Health Organization. HIV – Estimated percentage of pregnant women living with HIV who received antiretrovirals for preventing mother-to-child transmission. Global Health Observatory. 2024. Accessed September 11, 2024. https://www.who.int/data/gho/data/indicators/indicator-details/GHO/estimated-percentage-of-pregnant-women-living-with-hiv-who-received-antiretrovirals-for-preventing-mother-to-child-transmission

UNICEF. Progress in reducing new HIV infections among children has stagnated in recent years. Elimination of mother-to-child transmission. 2024. Accessed October 31, 2024. https://data.unicef.org/topic/hivaids/emtct/

World Health Organization. Investment case for eliminating mother-to-child transmission of syphilis: Promoting better maternal and child health and stronger health systems. Published online 2012

World Health Organization. Strategic Information. Global Sexually Transmitted Infections Programme. 2024. Accessed October 31, 2024. https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/stis/strategic-information

Graybill LA, Kasaro M, Freeborn K, et al. Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis. AIDS. 2020;34(5):761. https://doi.org/10.1097/QAD.0000000000002487.

Article  PubMed  Google Scholar 

Kerry A Thomson, James Hughes, Jared Baeten, et al. Increased Risk of HIV Acquisition Among Women Throughout Pregnancy and During the Postpartum Period: A Prospective Per-Coital-Act Analysis Among Women With HIV-Infected Partners. The Journal of Infectious Diseases. 2018;218(1):16–25. https://doi.org/10.1093/infdis/jiy113

The Lancet HIV. The path to elimination of vertical transmission of HIV. The Lancet HIV. 2022;9:2 e67. https://doi.org/10.1016/S2352-3018(22)00012-1.

Article  Google Scholar 

Moodley D, Esterhuizen T, Reddy L, et al. Incident HIV infection in pregnant and lactating women and its effect on mother-to-child transmission in South Africa. J Infect Dis. 2011;203(9):1231–4. https://doi.org/10.1093/infdis/jir017.

Article  PubMed  Google Scholar 

UNICEF, UNAIDS, WHO. Key considerations for programming and prioritization. Going the ‘Last Mile’ to EMTCT: A road map for ending the HIV epidemic in children. Published online February 2020

World Health Organization. Preventing HIV during pregnancy and breastfeeding in the context of PrEP. Published online 2017. Accessed October 29, 2024. https://www.who.int/publications/i/item/WHO-HIV-2017.09

Joseph Davey DL, Mvududu R, Mashele N, et al. Early pre-exposure prophylaxis (PrEP) initiation and continuation among pregnant and postpartum women in antenatal care in Cape Town, South Africa. J Int AIDS Soc. 2022;25(2):e25866. https://doi.org/10.1002/jia2.25866.

Article  PubMed  PubMed Central  Google Scholar 

Celum C, Hosek S, Tsholwana M, et al. PrEP uptake, persistence, adherence, and effect of retrospective drug level feedback on PrEP adherence among young women in southern Africa: Results from HPTN 082, a randomized controlled trial. PLoS Med. 2021;18(6):e1003670. https://doi.org/10.1371/journal.pmed.1003670.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bekker LG, Das M, Karim QA, et al. Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women. N Engl J Med. 2024;391(13):1179–92. https://doi.org/10.1056/NEJMoa2407001.

Article  CAS  PubMed  Google Scholar 

Wedi COO, Kirtley S, Hopewell S, Corrigan R, Kennedy S, Hemelaar J. Perinatal outcomes associated with maternal HIV infection: a systematic review and meta-analysis - ScienceDirect. The Lancet HIV. 2016;3(1):e33–48. https://doi.org/10.1016/S2352-3018(15)00207-6.

Article  PubMed  Google Scholar 

World Health Organization. Data on the HIV response. The Global Health Observatory. 2024. Accessed September 3, 2024. https://www.who.int/data/gho/data/themes/hiv-aids/data-on-the-hiv-aids-response

Woldesenbet S, Cheyip M, Lombard C, et al. Progress towards the UNAIDS 95–95-95 targets among pregnant women in South Africa: Results from the 2017 and 2019 national Antenatal HIV Sentinel Surveys. PLoS ONE. 2022;17(7):e0271564. https://doi.org/10.1371/journal.pone.0271564.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ntombela N, Kharsany A, Soogun A, et al. Viral suppression among pregnant adolescents and women living with HIV in rural KwaZulu-Natal, South Africa: a cross sectional study to assess progress towards UNAIDS indicators and Implications for HIV Epidemic Control | Reproductive Health | Full Text. Reproductive Health. 2022;19(116). https://doi.org/10.1186/s12978-022-01419-5

Endalamaw Alamneh D, Shiferaw M, Getachew Demissie M, et al. Virological outcomes among pregnant women in ART | HIV. HIV AIDS (Auckl). 2023;15:206–2016. https://doi.org/10.2147/HIV.S389506.

Article  Google Scholar 

Woldesenbet SA, Kufa T, Barron P, et al. Viral suppression and factors associated with failure to achieve viral suppression among pregnant women in South Africa. AIDS. 2020;34(4):589–97. https://doi.org/10.1097/QAD.0000000000002457.

Article  PubMed  Google Scholar 

UNAIDS. Progress towards the Start Free, Stay, Free, AIDS Free Targets: 2020 Report.; 2020. https://free.unaids.org/

Bekker LG, Brown B, Joseph-Davey D, et al. Southern African guidelines on the safe, easy and effective use of pre-exposure prophylaxis: 2020. Southern African Journal of HIV Medicine. 2020;21(1):1152. https://doi.org/10.4102/sajhivmed.v21i1.1152.

Article  PubMed  PubMed Central  Google Scholar 

Hook EW. Syphilis. The Lancet. 2017;389(10078):1550–7. https://doi.org/10.1016/S0140-6736(16)32411-4.

Article  Google Scholar 

World Health Organization. STI: Incident cases of syphilis in 15-49 year olds (in thousands). The Global Health Observatory. 2024. Accessed November 26, 2024. https://www.who.int/data/gho/data/indicators/indicator-details/GHO/incident-cases-of-syphilis-in-individuals-(in-millions)

Stafford IA, Workowski KA, Bachmann LH. Syphilis Complicating Pregnancy and Congenital Syphilis. N Engl J Med. 2024;390(3):242–53. https://doi.org/10.1056/NEJMra2202762.

Article  CAS  PubMed  PubMed Central  Google Scholar 

European Centre for Disease Prevention and Control. Annual Epidemiological Report for 2022. ECDC; 2024

New York City Department of Health and Mental Hygiene. 2024 Health Advisory #4: Increases in Syphilis Among Females and Congenital Syphilis in New York City. NYC DHMH; 2024

Kojima N, Klausner JD. An Update on the Global Epidemiology of Syphilis. Curr Epidemiol Rep. 2018;5(1):24–38. https://doi.org/10.1007/s40471-018-0138-z.

Article  PubMed  PubMed Central  Google Scholar 

World Health Organization. Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021. Published online July 15, 2021. Accessed September 4, 2024. https://www.who.int/publications/i/item/9789240027077

Gilmour LS, Walls T. Congenital Syphilis: a Review of Global Epidemiology. Clin Microbiol Rev. 2023;36(2):e00126-e222. https://doi.org/10.1128/cmr.00126-22.

Article  PubMed  PubMed Central  Google Scholar 

Malisa RA, Ndaboine E, Chibwe E, et al. Treponema pallidum infection among women with macerated stillbirth in Mwanza Tanzania: an underestimated tragedy in Tanzania. Afr Health Sci. 2022;22(3):72–80. https://doi.org/10.4314/ahs.v22i3.9.

Article  PubMed  PubMed Central  Google Scholar 

Ojo OC, Arno JN, Tao G, Patel CG, Dixon BE. Syphilis testing adherence among women with livebirth deliveries: Indianapolis 2014–2016. BMC Pregnancy Childbirth. 2021;21(1):739. https://doi.org/10.1186/s12884-021-04211-8.

Article  PubMed  PubMed Central  Google Scholar 

Hawkes S, Matin N, Broutet N, Low N. Effectiveness of interventions to improve screening for syphilis in pregnancy: a systematic review and meta-analysis. Lancet Infect Dis. 2011;11(9):684–91. https://doi.org/10.1016/S1473-3099(11)70104-9.

Article  PubMed  Google Scholar 

World Health Organization. Proportion of women accessing antenatal care services who were tested for syphilis. Maternal, Newborn, Child and Adolescent Health and Ageing. 2024. Accessed September 11, 2024. https://platform.who.int/data/maternal-newborn-child-adolescent-ageing/indicator-explorer-new/mca/proportion-of-women-accessing-antenatal-care-services-who-were-tested-for-syphilis

Goh BT, Thornton AC. Antenatal screening for syphilis. Sex Transm Infect. 2007;83(5):345–6. https://doi.org/10.1136/sti.2007.026633.

Article  PubMed  PubMed Central  Google Scholar 

Nurse-Findlay S, Taylor MM, Savage M, et al. Shortages of benzathine penicillin for prevention of mother-to-child transmission of syphilis: An evaluation from multi-country surveys and stakeholder interviews. PLoS Med. 2017;14(12):e1002473. https://doi.org/10.1371/journal.pmed.1002473.

Article  PubMed  PubMed Central  Google Scholar 

Castilho JL, Fonseca FF, Kim A, et al. Prenatal syphilis and adverse pregnancy outcomes in women with HIV receiving ART in Brazil: a population-based study. Lancet Reg Health - Am. 2024;39:100894. https://doi.org/10.1016/j.lana.2024.100894.

Article  PubMed  PubMed Central  Google Scholar 

Tannis A, Miele K, Carlson JM, et al. Syphilis Treatment Among People Who Are Pregnant in Six U.S. States, 2018–2021. Obstetrics & Gynecology. Published online April 17, 2024. https://doi.org/10.1097/AOG.0000000000005586

World Health Organization. WHO Guideline on Syphilis Screening and Treatment for Pregnant Women. In: WHO Guideline on Syphilis Screening and Treatment for Pregnant Women. World Health Organization; 2017. Accessed July 10, 2024. https://www.ncbi.nlm.nih.gov/books/NBK499744/

Center for Disease Control and Prevention (CDC). Syphilis During Pregnancy. Sexually Transmitted Infections Treatment Guidelines, 2021. 2021. Accessed October 28, 2024. https://www.cdc.gov/std/treatment-guidelines/syphilis-pregnancy.htm

Sheffield JS, Sánchez PJ, Morris G, et al. Congenital syphilis after maternal treatment for syphilis during pregnancy. Am J Obstet Gynecol. 2002;186(3):569–73. https://doi.org/10.1067/mob.2002.121541.

Article  PubMed  Google Scholar 

Nkamba D, Mwenechanya M, Kilonga AM, et al. Barriers and facilitators to the implementation of antenatal syphilis screening and treatment for the prevention of congenital syphilis in the Democratic Republic of Congo and Zambia: results of qualitative formative research. BMC Health Serv Res. 2017;17(1):556. https://doi.org/10.1186/s12913-017-2494-7.

Article  PubMed  PubMed Central  Google Scholar 

Bocoum FY, Kouanda S, Zarowsky C. Barriers to antenatal syphilis screening in Burkina Faso. Pan Afr Med J. 2014;17(Suppl 1):12. https://doi.org/10.11694/pamj.supp.2014.17.1.3423.

Article  PubMed  Pu

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