Devaraju, M. et al. Beyond TORCH: a narrative review of the impact of antenatal and perinatal infections on the risk of disability. Neurosci. Biobehav. Rev. 153, 105390 (2023).
Article PubMed PubMed Central Google Scholar
Ander, S. E., Diamond, M. S. & Coyne, C. B. Immune responses at the maternal–fetal interface. Sci. Immunol. 4, eaat6114 (2019).
Article CAS PubMed PubMed Central Google Scholar
Espino, A., El Costa, H., Tabiasco, J., Al-Daccak, R. & Jabrane-Ferrat, N. Innate immune response to viral infections at the maternal–fetal interface in human pregnancy. Front. Med. 8, 674645 (2021).
Hoo, R., Nakimuli, A. & Vento-Tormo, R. Innate immune mechanisms to protect against infection at the human decidual–placental interface. Front. Immunol. 11, 2070 (2020).
Article CAS PubMed PubMed Central Google Scholar
Semmes, E. C. & Coyne, C. B. Innate immune defenses at the maternal–fetal interface. Curr. Opin. Immunol. 74, 60–67 (2022).
Article CAS PubMed Google Scholar
Arutyunyan, A. et al. Spatial multiomics map of trophoblast development in early pregnancy. Nature 616, 143–151 (2023).
Article CAS PubMed PubMed Central Google Scholar
Greenbaum, S. et al. A spatially resolved timeline of the human maternal–fetal interface. Nature 619, 595–605 (2023).
Article CAS PubMed PubMed Central Google Scholar
Moore, A. R. et al. Gestationally dependent immune organization at the maternal–fetal interface. Cell Rep. 41, 111651 (2022). This paper describes the immuno-phenotyping of circulating, endovascular and tissue-resident cells at the maternal–fetal interface throughout gestation, and distinguishes maternal and fetal contributions.
Article CAS PubMed PubMed Central Google Scholar
Gauster, M., Moser, G., Wernitznig, S., Kupper, N. & Huppertz, B. Early human trophoblast development: from morphology to function. Cell Mol. Life Sci. 79, 345 (2022).
Article CAS PubMed PubMed Central Google Scholar
Arranz-Solis, D., Mukhopadhyay, D. & Saeij, J. J. P. Toxoplasma effectors that affect pregnancy outcome. Trends Parasitol. 37, 283–295 (2021).
Article CAS PubMed Google Scholar
Schatten, H. & Constantinescu, G. M. Comparative Reproductive Biology 1st edn (Blackwell, 2007).
Wooding, F. B. P. & Burton, G. Comparative Placentation: Structures, Functions and Evolution (Springer, 2008).
Kingdom, J., Huppertz, B., Seaward, G. & Kaufmann, P. Development of the placental villous tree and its consequences for fetal growth. Eur. J. Obstet. Gynecol. Reprod. Biol. 92, 35–43 (2000).
Article CAS PubMed Google Scholar
Reyes, L. & Golos, T. G. Hofbauer cells: their role in healthy and complicated pregnancy. Front. Immunol. 9, 2628 (2018).
Article PubMed PubMed Central Google Scholar
Loegl, J. et al. Hofbauer cells of M2a, M2b and M2c polarization may regulate feto-placental angiogenesis. Reproduction 152, 447–455 (2016).
Article CAS PubMed Google Scholar
Thomas, J. R., Naidu, P., Appios, A. & McGovern, N. The ontogeny and function of placental macrophages. Front. Immunol. 12, 771054 (2021).
Article CAS PubMed PubMed Central Google Scholar
Guttman, J. A. & Finlay, B. B. Tight junctions as targets of infectious agents. Biochim. Biophys. Acta 1788, 832–841 (2009).
Article CAS PubMed Google Scholar
Ander, S. E. et al. Human placental syncytiotrophoblasts restrict Toxoplasma gondii attachment and replication and respond to infection by producing immunomodulatory chemokines. mBio 9, e01678-17 (2018).
Article PubMed PubMed Central Google Scholar
Robbins, J. R., Zeldovich, V. B., Poukchanski, A., Boothroyd, J. C. & Bakardjiev, A. I. Tissue barriers of the human placenta to infection with Toxoplasma gondii. Infect. Immun. 80, 418–428 (2012).
Article CAS PubMed PubMed Central Google Scholar
Robbins, J. R., Skrzypczynska, K. M., Zeldovich, V. B., Kapidzic, M. & Bakardjiev, A. I. Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. PLoS Pathog. 6, e1000732 (2010).
Article PubMed PubMed Central Google Scholar
Zeldovich, V. B. et al. Placental syncytium forms a biophysical barrier against pathogen invasion. PLoS Pathog. 9, e1003821 (2013).
Article PubMed PubMed Central Google Scholar
Bayer, A. et al. Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection. Cell Host Microbe 19, 705–712 (2016).
Article CAS PubMed PubMed Central Google Scholar
Corry, J., Arora, N., Good, C. A., Sadovsky, Y. & Coyne, C. B. Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal–fetal interface. Proc. Natl Acad. Sci. USA 114, 9433–9438 (2017).
Article CAS PubMed PubMed Central Google Scholar
Wickramage, I. et al. SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas. Cell Host Microbe 31, 1185–1199.e10 (2023). This paper reveals that dsRNA produced by imprinted placental microRNA clusters in primates and rodents triggers constitutive type III interferon production, conferring innate antiviral protection in these haemochorial placentas.
Article CAS PubMed PubMed Central Google Scholar
Yang, L. et al. Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal–fetal interface. eLife 11, e79794 (2022). This study defines the innate immunological properties of trophoblast and decidua organoids derived from term placental tissue, revealing distinct responses to viral infection and differential susceptibility to CMV.
Article CAS PubMed PubMed Central Google Scholar
Burton, G. J., Watson, A. L., Hempstock, J., Skepper, J. N. & Jauniaux, E. Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J. Clin. Endocrinol. Metab. 87, 2954–2959 (2002).
Article CAS PubMed Google Scholar
Pollheimer, J., Vondra, S., Baltayeva, J., Beristain, A. G. & Knofler, M. Regulation of placental extravillous trophoblasts by the maternal uterine environment. Front. Immunol. 9, 2597 (2018).
Article PubMed PubMed Central Google Scholar
Apps, R., Gardner, L., Sharkey, A. M., Holmes, N. & Moffett, A. A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1. Eur. J. Immunol. 37, 1924–1937 (2007).
Article CAS PubMed PubMed Central Google Scholar
Chen, L. J., Han, Z. Q., Zhou, H., Zou, L. & Zou, P. Inhibition of HLA-G expression via RNAi abolishes resistance of extravillous trophoblast cell line TEV-1 to NK lysis. Placenta 31, 519–527 (2010).
Chumbley, G., King, A., Robertson, K., Holmes, N. & Loke, Y. W. Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. Cell Immunol. 155, 312–322 (1994).
Article CAS PubMed Google Scholar
Yang, Y. et al. Advances in the study of HLA class Ib in maternal–fetal immune tolerance. Front. Immunol. 13, 976289 (2022).
Comments (0)