Lynch, S. V. & Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med. 375, 2369–2379 (2016).
Article CAS PubMed Google Scholar
Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021).
Article CAS PubMed Google Scholar
Procházková, N. et al. Advancing human gut microbiota research by considering gut transit time. Gut 72, 180–191 (2023).
Procházková, N. et al. Gut physiology and environment explain variations in human gut microbiome composition and metabolism. Nat. Microbiol. 9, 3210–3225 (2024).
Article PubMed PubMed Central Google Scholar
Laursen, M. F., Bahl, M. I. & Licht, T. R. Settlers of our inner surface – factors shaping the gut microbiota from birth to toddlerhood. FEMS Microbiol. Rev. 45, fuab001 (2021).
Article CAS PubMed PubMed Central Google Scholar
McCallum, G. & Tropini, C. The gut microbiota and its biogeography. Nat. Rev. Microbiol. 22, 105–118 (2023).
Ng, K. M. et al. Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota. mBio 14, e00753-23 (2023).
Article PubMed PubMed Central Google Scholar
Duncan, S. H., Louis, P., Thomson, J. M. & Flint, H. J. The role of pH in determining the species composition of the human colonic microbiota. Env. Microbiol. 11, 2112–2222 (2009).
Firrman, J. et al. The impact of environmental pH on the gut microbiota community structure and short chain fatty acid production. FEMS Microbiol. Ecol. 98, fiac038 (2022).
Nugent, S. G., Kumar, D., Rampton, D. S. & Evans, D. F. Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Gut 48, 571–577 (2001).
Article CAS PubMed PubMed Central Google Scholar
Ilhan, Z. E., Marcus, A. K., Kang, D.-W., Rittmann, B. E. & Krajmalnik-Brown, R. pH-mediated microbial and metabolic interactions in fecal enrichment cultures. mSphere 2, e00047-17 (2017).
Article PubMed PubMed Central Google Scholar
Walker, A. W., Duncan, S. H., Carol McWilliam Leitch, E., Child, M. W. & Flint, H. J. pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon. Appl. Env. Microbiol. 71, 3692–3700 (2005).
Thornton, J. R. High colonic pH promotes colorectal cancer. Lancet 16, 1081–1083 (1981).
Fallingborg, J. Intraluminal pH of the human gastrointestinal tract. Dan. Med. Bull. 46, 183–196 (1999).
Fallingborg, J., Christensen, A., Jacobsen, A. & Rasmussen, S. N. Very low intraluminal colonic pH in patients with active ulcerative colitis. Dig. Dis. Sci. 38, 1989–1993 (1993).
Article CAS PubMed Google Scholar
Folz, J. et al. Human metabolome variation along the upper intestinal tract. Nat. Metab. 5, 777–788 (2023).
Article CAS PubMed PubMed Central Google Scholar
Torp, A. M., Bahl, M. I., Boisen, A. & Licht, T. R. Optimizing oral delivery of next generation probiotics. Trends Food Sci. Technol. 119, 101–109 (2022).
Shalon, D. et al. Profiling the human intestinal environment under physiological conditions. Nature 617, 581–591 (2023).
Article CAS PubMed PubMed Central Google Scholar
Mikolajczyk, A. E., Watson, S., Surma, B. L. & Rubin, D. T. Assessment of tandem measurements of pH and total gut transit time in healthy volunteers. Clin. Transl. Gastroenterol. 6, e100 (2015).
Article PubMed PubMed Central Google Scholar
Evans, D. F. et al. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 29, 1035–1041 (1988).
Article CAS PubMed PubMed Central Google Scholar
Quigley, E. M. M. & Turnberg, L. A. pH of the microclimate lining human gastric and duodenal mucosa in vivo studies in control subjects and in duodenal ulcer patients. Gastroenterology 92, 1876–1884 (1987).
Article CAS PubMed Google Scholar
Abuhelwa, A. Y., Foster, D. J. R. & Upton, R. N. A quantitative review and meta-models of the variability and factors affecting oral drug absorption – part I: gastrointestinal pH. AAPS J. 18, 1309–1321 (2016).
Article CAS PubMed Google Scholar
Fadda, H. M., Hellström, P. M. & Webb, D. L. Intra- and inter-subject variability in gastric pH following a low-fat, low-calorie meal. Int. J. Pharm. 625, 122069 (2022).
Article CAS PubMed Google Scholar
Simonian, H. P., Vo, L., Doma, S., Fisher, R. S. & Parkman, H. P. Regional postprandial differences in pH within the stomach and gastroesophageal junction. Dig. Dis. Sci. 50, 2276–2285 (2005).
Engevik, A. C., Kaji, I. & Goldenring, J. R. The physiology of the gastric parietal cell. Physiol. Rev. 100, 573–602 (2020).
Article CAS PubMed Google Scholar
Adibi, S. A. Intestinal phase of protein assimilation in man. Am. J. Clin. Nutr. 29, 205–215 (1976).
Article CAS PubMed Google Scholar
Beasley, D. E., Koltz, A. M., Lambert, J. E., Fierer, N. & Dunn, R. R. The evolution of stomach acidity and its relevance to the human microbiome. PLoS ONE 10, e0134116 (2015).
Article PubMed PubMed Central Google Scholar
Schreiber, S. et al. The spatial orientation of Helicobacter pylori in the gastric mucus. Proc. Natl Acad. Sci. USA 14, 5024–5029 (2004).
Heatley, N. G. Mucosubstance as a barrier to diffusion. Gastroenterology 37, 313–317 (1959).
Article CAS PubMed Google Scholar
Feldman, M. Gastric bicarbonate secretion in humans. J. Clin. Invest. 1, 295–303 (1983).
Yang, I., Nell, S. & Suerbaum, S. Survival in hostile territory: the microbiota of the stomach. FEMS Microbiol. Rev. 37, 736–761 (2013).
Article CAS PubMed Google Scholar
O’Hara, A. M. & Shanahan, F. The gut flora as a forgotten organ. EMBO Rep. 7, 688–693 (2006).
Article PubMed PubMed Central Google Scholar
Delgado, S., Cabrera-Rubio, R., Mira, A., Suárez, A. & Mayo, B. Microbiological survey of the human gastric ecosystem using culturing and pyrosequencing methods. Microb. Ecol. 65, 763–772 (2013).
Article CAS PubMed Google Scholar
Stearns, J. C. et al. Bacterial biogeography of the human digestive tract. Sci. Rep. 1, 170 (2011).
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