Mariya Miteva-Hristova, Elitsa Sabeva-Peeva, Ivaylo Hristov

DOI : 10.62610/RJOR.2025.2.17.6

Aim of the study Modern periodontal treatment has two main tasks. The first is to eliminate microorganisms and their toxins, thus affecting inflammatory processes. The second task is related to the complete regeneration of the lost periodontal structures. Today, clinicians have increasingly begun to look for innovative surgical approaches to ensure predictable regenerative outcomes. This systematic review aims to examine which combined regenerative methods have been most preferred over the years, in which bone defects they have been applied, and how effective they have been. Materials and methods. The electronic databases Web of Science, Scopus and PubMed were searched for publications related to the topic of this study for the period January 2000 to January 2025. The research was executed in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Fifteen studies were included in this systematic review. Results The different combined methods used in the treatment of vertical bone defects for the last 25 years were investigated and their results related to the parameters of probing depth, clinical attachment level and bone fill were analysed. Conclusions This systematic review can be successfully used as a guide as to which combined methods in the contemporary treatment of vertical bone defects are most preferred and effective.