Groenewegen, A., Rutten, F. H., Mosterd, A. & Hoes, A. W. Epidemiology of heart failure. Eur. J. Heart Fail. 22, 1342–1356 (2020).
Neubauer, S. The failing heart—an engine out of fuel. N. Engl. J. Med. 356, 1140–1151 (2007).
Bertero, E. & Maack, C. Metabolic remodelling in heart failure. Nat. Rev. Cardiol. 15, 457–470 (2018).
Article CAS PubMed Google Scholar
Bertero, E. & Maack, C. Calcium signaling and reactive oxygen species in mitochondria. Circ. Res. 122, 1460–1478 (2018).
Article CAS PubMed Google Scholar
Cannata, A. & McDonagh, T. A. Heart failure with preserved ejection fraction. N. Engl. J. Med. 392, 173–184 (2025).
Article CAS PubMed Google Scholar
Maack, C., Vilahur, G., Ruiz-Meana, M. & Hausenloy, D. New COST Action ‘EUropean network to tackle METAbolic alterations in HEART failure’ (EU-METAHEART). Eur. Heart J. 45, 4460–4463 (2024).
Article CAS PubMed Google Scholar
Mericskay, M. et al. Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-025-01166-7 (2025).
Liberale, L. et al. Vascular (dys)function in the failing heart. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-025-01163-w (2025).
Andreadou, I. et al. Immunometabolism in heart failure. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-025-01165-8 (2025).
Aksentijevic, D. et al. Mechano-energetic uncoupling in heart failure. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-025-01167-6 (2025).
Paulus, W. J. & Tschöpe, C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J. Am. Coll. Cardiol. 62, 263–271 (2013).
Vilahur, G., Kleinbongard, P., Zuurbier, C. J. & Core Group of the COST Action EU-METAHEART (CA22169). In memoriam: Ioanna Andreadou (1965–2025). Eur. Heart J. 46, 1699–1701 (2025).
Lopaschuk, G. D. et al. Cardiac energy metabolism in heart failure. Circ. Res. 128, 1487–1513 (2021).
Article CAS PubMed PubMed Central Google Scholar
Dyck, J. R. B. In memory of Dr Gary D. Lopaschuk, PhD (1955–2025). JACC Basic Transl. Sci 10, 704–705 (2025).
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