Dysregulation of AR and ERα caused ovarian alterations in gerbils prenatally exposed to 17α-ethinylestradiol and pequi oil

Apolloni LB, Bruno JB, Alves BG et al (2016) The role of androgens in mammals folliculogenesis. Acta Sci Vet 44(1):15

Google Scholar 

Arnal JF, Lenfant F, Metivier R et al (2017) Membrane and nuclear estrogen receptor alpha actions: from tissue specificity to medical implications. Physiol Rev 97(3):1045–1087. https://doi.org/10.1152/physrev.00024.2016

Article  PubMed  Google Scholar 

Astapova O, Minor BMN, Hammes SR (2019) Physiological and pathological androgen actions in the ovary. Endocrinology 160(5):1166–1174. https://doi.org/10.1210/en.2019-00101

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bancroft J, Cawood EH (1996) Androgens and the menopause; a study of 40–60-year-old women. Clin Endocrinol (Oxf) 45(5):577–587. https://doi.org/10.1046/j.1365-2265.1996.00846.x

Article  CAS  PubMed  Google Scholar 

Baptista A, Gonçalves RV, Bressan J et al (2018) Crude extracts and fractions of cashew (Anacardium occidentale L.), Cajui (Anacardium microcarpum), and pequi (Caryocar brasiliense C.): a systematic review. Hindawi Oxidative Med Cell Longevity. https://doi.org/10.1155/2018/3753562

Article  Google Scholar 

Barnett KR, Schilling C, Greenfeld CR et al (2006) Ovarian follicle development and transgenic mouse models. Hum Reprod Update 12(5):537–555. https://doi.org/10.1093/humupd/dml022

Article  CAS  PubMed  Google Scholar 

Braga KMS, Araujo EG, Sellke FW (2022) Pequi fruit extract increases antioxidant enzymes and reduces oxidantes in human coronary arterial endothelial cells. Antioxidants 11(3):474. https://doi.org/10.3390/antiox11030474

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brito RM, Barcia MT, Farias CAA et al (2022) Bioactive compounds of pequi pulp and oil extracts modulate antioxidant activity and antiproliferative activity in cocultured blood mononuclear cells and breast cancer cells. Food Nutr Res 27:66. https://doi.org/10.29219/fnr.v66.8282

Article  CAS  Google Scholar 

Carneiro CR, Alhaji AM, da Silva CAS et al (2023) Potential challenges of the extraction of carotenoids and fatty acids from pequi (Caryocar brasiliense) oil. Foods 12(9):1907. https://doi.org/10.3390/foods12091907

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carvalho-Silva PM, Zuffo JA, Mendes MEHS et al (2024) Histological investigation in aging male and female gerbil prostates after prenatal exposure to pequi (Caryocar brasiliense Cambess) oil and 17α-ethinylestradiol. Int J Environ Health Res 34(9):3073–3083. https://doi.org/10.1080/09603123.2023.2294067

Article  CAS  Google Scholar 

Colombo NBR, Rangel MP, Martins V et al (2015) Caryocar Brasiliense Camb. protects against genomic and oxidative damage in urethane-induced lung carcinogenesis. Braz J Med Biol Res 48:852–862. https://doi.org/10.1590/1414-431X20154467

Article  CAS  PubMed  PubMed Central  Google Scholar 

Couse JF, Yates MM, Rodriguez KF et al (2006) The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad. Endocrinology 147(8):3666–3678. https://doi.org/10.1210/en.2006-0276

Article  CAS  PubMed  Google Scholar 

Da Silva DC, Da Silva JFG, Monteiro JA et al (2024) Effects of prenatal exposure to pequi oil and 17α-ethinylestradiol on folliculogenesis in gerbil (Meriones unguiculatus) ovaries. Emerg Anim Spec. https://doi.org/10.1016/j.eas.2024.100049

Article  Google Scholar 

Díaz-Hernández V, Caldelas I, Montaño LM et al (2019) Morphological rearrangement of the cortical region, in aging ovaries. Histol Histopathol 34(7):775–789. https://doi.org/10.14670/HH-18-078

Article  PubMed  Google Scholar 

Dos Santos CR, Arcanjo GS, de Souza Santos LV et al (2021) Aquatic concentration and risk assessment of pharmaceutically active compounds in the environment. Environ Pollut 290:118049. https://doi.org/10.1016/j.envpol.2021.118049

Article  CAS  PubMed  Google Scholar 

Emmen JM, Couse JF, Elmore SA (2005) In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER) and ER null mice indicate a role for ER in follicular maturation. Endocrinology 146(6):2817–2826. https://doi.org/10.1210/en.2004-1108

Article  CAS  PubMed  Google Scholar 

Feeley KM, Wells M (2001) Precursor lesions of ovarian epithelial malignancy. Histopathology 38(2):87–95. https://doi.org/10.1046/j.1365-2559.2001.01042.x

Article  CAS  PubMed  Google Scholar 

Ferré-Pujol P, Otsuki J, Funahashi H, Nakatsuka M (2021) The thickness and density of the ovarian tunica albuginea increases with age in transgender patients. Reprod Sci 28(5):1339–1346. https://doi.org/10.1007/s43032-020-00390-5

Article  CAS  PubMed  Google Scholar 

Fleury FG, Guimarães LRF, Rezende EB et al (2021) Prenatal and pubertal exposure to 17α-ethinylestradiol cause morphological changes in the prostate of old gerbils. Cell Biol Int 45(10):2074–2085. https://doi.org/10.1002/cbin.11656

Article  CAS  PubMed  Google Scholar 

Guzmán-Silva MA, Costa-Neves M (2006) Incipient spontaneous granulosa cell tumour in the gerbil. Meriones Unguiculatus Lab Anim 40(1):96–101. https://doi.org/10.1258/002367706775404435

Article  PubMed  Google Scholar 

Jia M, Dahlman-Wright K, Gustafsson J (2015) Estrogen receptor alpha and beta in health and disease. Best Pract Res Clin Haematol 29(4):557–568. https://doi.org/10.1016/j.beem.2015.04.008

Article  CAS  Google Scholar 

Kimura S, Matsumoto T, Matsuyama R et al (2007) Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure. Trends Endocrinol Metab 18(5):183–189. https://doi.org/10.1016/j.tem.2007.04.002

Article  CAS  PubMed  Google Scholar 

Kinnear HM, Tomaszewski CE, Chang AL et al (2020) The ovarian stroma as a new frontier. Reproduction 160(3):25–39. https://doi.org/10.1530/REP-19-0501

Article  Google Scholar 

Leonel ECR, Campos SGP, Bedolo CM et al. (2021). The Mongolian gerbil (Meriones unguiculatus): reproductive organs. In Starck JM (ed), Microscopic Anatomy of the Animals. 1ed.Hoboken, NJ, EUA: Wiley Online Library. https://doi.org/10.1002/9781118158036.maa20180150

Li L, Shi X, Shi Y et al (2021) The signaling pathways involved in ovarian follicle development. Front Physiol 12:730196. https://doi.org/10.3389/fphys.2021.730196

Article  PubMed  PubMed Central  Google Scholar 

Martorell J (2017) Reproductive disorders in pet rodents. Vet Clin North Am Exot Anim Pract 20(2):589–608. https://doi.org/10.1016/j.cvex.2016.11.015

Article  PubMed  Google Scholar 

Miranda-Vilela AL, Grisolia CK, Longo JPF et al (2014) Oil rich in carotenoids instead of vitamins c and e as a better option to reduce doxorubicininduced damage to normal cells of ehrlich tumor-bearing mice: hematological, toxicological and histopathological evaluations. J Nutr Biochem 25:1161–1176. https://doi.org/10.1016/j.jnutbio.2014.06.005

Article  CAS  PubMed  Google Scholar 

Nascimento-Silva NRRD, Naves MMV (2019) Potential of whole pequi (Caryocar spp.) fruit-pulp, almond, oil, and shell-as a medicinal food. J Med Food 22(9):952–962. https://doi.org/10.1089/jmf.2018.0149

Article  CAS  PubMed  Google Scholar 

Nishino N, Totsukawa K (1996) Study on the estrous cycle in the Mongolian gerbil (Meriones unguiculatus). Exp Anim 45:283–288. https://doi.org/10.1538/expanim.45.283

Article  CAS  PubMed  Google Scholar 

Ombredane AS, Silva LRA, Araujo VHS (2022) Pequi oil (Caryocar brasilense Cambess) nanoemulsion alters cell proliferation and demages key organelles in triple-negative breast cancer cells in vitro. Biomed Pharmacother 153:113348. https://doi.org/10.1016/j.biopha.2022.113348

Article  CAS  PubMed  Google Scholar 

Pepene CE (2012) Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction. Gynecol Endocrinol 28(5):370–374. https://doi.org/10.3109/09513590.2011.632792

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