MST1 modulates inflammatory responses by targeting the NF-κB/NLRP3 pathway in LPS-induced acute lung injury

Amatullah H, Maron-Gutierrez T, Shan Y, Gupta S, Tsoporis JN, Varkouhi AK, Teixeira Monteiro AP, He X, Yin J, Marshall JC, Rocco PRM, Zhang H, Kuebler WM, Dos Santos CC (2020) Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury. Redox Biol 38:101796. https://doi.org/10.1016/j.redox.2020.101796

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183(2):787–791. https://doi.org/10.4049/jimmunol.0901363

Article  CAS  PubMed  Google Scholar 

Cao Y, Chen J, Ren G, Zhang Y, Tan X, Yang L (2019) Punicalagin prevents inflammation in LPS-Induced RAW264.7 macrophages by inhibiting FoxO3a/autophagy signaling pathway. Nutrients 11(11):2794. https://doi.org/10.3390/nu11112794

Chen G, Hou Y, Li X, Pan R, Zhao D (2021) Sepsis-induced acute lung injury in young rats is relieved by calycosin through inactivating the HMGB1/MyD88/NF-κB pathway and NLRP3 inflammasome. Int Immunopharmacol 96:107623. https://doi.org/10.1016/j.intimp.2021.107623

Article  CAS  PubMed  Google Scholar 

Chen H, Bai C, Wang X (2010) The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine. Expert Rev Respir Med 4(6):773–783. https://doi.org/10.1586/ers.10.71

Article  CAS  PubMed  Google Scholar 

Daniela A-O, Jonathan C (2016) Hras helps hippo heterodimerize to evade tumor suppression. Small GTPases 9(4):327–331. https://doi.org/10.1080/21541248.2016.1228794

Article  CAS  Google Scholar 

Fan E, Brodie D, Slutsky A (2018) Acute respiratory distress syndrome: advances in diagnosis and treatment. JAMA 319(7):698–710. https://doi.org/10.1001/jama.2017.21907

Article  PubMed  Google Scholar 

Fan F, He Z, Kong L-L, Chen Q, Yuan Q, Zhang S, Ye J, Liu H, Sun X, Geng J, Yuan L, Hong L, Xiao C, Zhang W, Sun X, Li Y, Wang P, Huang L, Wu X, Ji Z, Wu Q, Xia N-S, Gray NS, Chen L, Yun C-H, Deng X, Zhou D (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med 8(352):352ra108-352ra108. https://doi.org/10.1126/scitranslmed.aaf2304

Article  CAS  PubMed  Google Scholar 

Farooq MA, Niazi AK, Akhtar J, Saifullah Farooq M, Souri Z, Karimi N, Rengel Z (2019) Acquiring control: the evolution of ROS-Induced oxidative stress and redox signaling pathways in plant stress responses. Plant Physiol Biochem 141:353–369. https://doi.org/10.1016/j.plaphy.2019.04.039

Article  CAS  PubMed  Google Scholar 

Gao J, Wang N, Song W, Yuan Y, Teng Y, Liu Z (2024) Mechanisms underlying the synergistic effects of chuanxiong combined with Chishao on treating acute lung injury based on network pharmacology and molecular docking combined with preclinical evaluation. J Ethnopharmacol 325:117862. https://doi.org/10.1016/j.jep.2024.117862

Article  CAS  PubMed  Google Scholar 

Guo ZF, Tongmuang N, Li C, Zhang C, Hu L, Capreri D, Zuo MX, Summer R, Sun J (2024) Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice. JCI Insight 9(17):e178208. https://doi.org/10.1172/jci.insight.178208

Article  PubMed  PubMed Central  Google Scholar 

Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M (2016) MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest 126(11):4125–4139. https://doi.org/10.1172/jci87043

Article  PubMed  PubMed Central  Google Scholar 

Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1(6):a001651. https://doi.org/10.1101/cshperspect.a001651

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee IY, Lim JM, Cho H, Kim E, Kim Y, Oh HK, Yang WS, Roh KH, Park HW, Mo JS, Yoon JH, Song HK, Choi EJ (2019) MST1 negatively regulates TNFα-Induced NF-κB signaling through modulating LUBAC activity. Mol Cell 73(6):1138–1149. https://doi.org/10.1016/j.molcel.2019.01.022

Article  CAS  PubMed  Google Scholar 

Li T, Wen Y, Lu Q, Hua S, Hou Y, Du X, Zheng Y, Sun S (2023) MST1/2 in inflammation and immunity. Cell Adh Migr 17(1):1–15. https://doi.org/10.1080/19336918.2023.2276616

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long F, Hu L, Chen Y, Duan X, Xie K, Feng J, Wang M (2023) RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway. Inflamm Res 72(4):731–744. https://doi.org/10.1007/s00011-023-01705-3

Article  CAS  PubMed  Google Scholar 

McGettrick A, O’Neill L (2013) NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases. Diabetes Obes Metab 15:19–25. https://doi.org/10.1111/dom.12169

Article  CAS  PubMed  Google Scholar 

Peng H, Yao F, Zhao J, Zhang W, Chen L, Wang X, Yang P, Tang J, Chi Y (2023) Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials. Exploration (Beijing) 3(2):20220115. https://doi.org/10.1002/exp.20220115

Article  CAS  PubMed  Google Scholar 

Rehring JF, Bui TM, Galán-Enríquez CS, Urbanczyk JM, Ren X, Wiesolek HL, Sullivan DP, Sumagin R (2021) Released myeloperoxidase attenuates neutrophil migration and accumulation in inflamed tissue. Front Immunol 12:654259. https://doi.org/10.3389/fimmu.2021.654259

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roh KH, Lee Y, Yoon JH, Lee D, Kim E, Park E, Lee IY, Kim TS, Song HK, Shin J, Lim DS, Choi EJ (2020) TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-κB signaling pathway in macrophages. Cell Mol Life Sci 78(5):2315–2328. https://doi.org/10.1007/s00018-020-03650-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sack M, Fyhrquist F, Saijonmaa O, Fuster V, Kovacic JC (2017) Basic biology of oxidative stress and the cardiovascular system: part 1 of a 3-part series. J Am Coll Cardiol 70(2):196–211. https://doi.org/10.1016/j.jacc.2017.05.034

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shang X, Zhang Y, Xu J, Li M, Wang X, Yu R (2020) SRV2 promotes mitochondrial fission and Mst1-Drp1 signaling in LPS-induced septic cardiomyopathy. Aging (Albany N. Y.) 12(2):1417–1432. https://doi.org/10.18632/aging.102691

Article  Google Scholar 

Shao X, Sun C, Tang X, Zhang X, Han D, Liang S, Qu R, Hui X, Shan Y, Hu L, Fang H, Zhang H, Wu X, Chen C (2020) Allium sativumanti-inflammatory and intestinal microbiota modulation properties of Jinxiang garlic ( L.) polysaccharides toward dextran sodium sulfate-induced colitis. J Agric Food Chem 68(44):12295–12309. https://doi.org/10.1021/acs.jafc.0c04773

Article  CAS  PubMed  Google Scholar 

Shi Z, Zhou Z (2017) MST kinases in innate immune signaling. Cell Stress 2(1):4–13. https://doi.org/10.15698/cst2018.01.119

Song H, Wang M, Xin T (2019) Mst1 contributes to nasal epithelium inflammation via augmenting oxidative stress and mitochondrial dysfunction in a manner dependent on Nrf2 inhibition. J Cell Physiol 234(12):23774–23784. https://doi.org/10.1002/jcp.28945

Article  CAS  PubMed  Google Scholar 

Tang H, Guo Z, Tang X, Gao J, Wang W, Huang H, Zheng X, Cheng H, Sheng Y, Sun L (2021) MST1 modulates Th17 activation in psoriasis via regulating TLR4-NF-κB pathway. Hum Cell 34(1):28–36. https://doi.org/10.1007/s13577-020-00423-w

Article  CAS  PubMed  Google Scholar 

Tang J, Xu L, Zeng Y, Gong F (2020) Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway. Int Immunopharmacol 91:107272. https://doi.org/10.1016/j.intimp.2020.107272

Article  CAS  PubMed  Google Scholar 

Tian Y, Song H, Jin D, Hu N, Sun L (2020) MST1-Hippo pathway regulates inflammation response following myocardial infarction through inhibiting HO-1 signaling pathway. J Recept Signal Transduct Res 40(3):231–236. https://doi.org/10.1080/10799893.2020.1726954

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