Angiopoietins: multifaceted mediators in the pathogenesis of joint-related disorders

Ao X, Li Y, Jiang T et al (2023) Angiopoietin-2 promotes mechanical stress-induced extracellular matrix degradation in annulus fibrosus via the HIF-1α/NF-κB signaling pathway. Orthop Surg 15:2410–2422. https://doi.org/10.1111/os.13797

Article  PubMed  PubMed Central  Google Scholar 

Augustin HG, Koh GY, Thurston G, Alitalo K (2009) Control of vascular morphogenesis and homeostasis through the angiopoietin-tie system. Nat Rev Mol Cell Biol 10:165–177. https://doi.org/10.1038/nrm2639

Article  CAS  PubMed  Google Scholar 

Bhattacharya D, Chaudhuri S, Singh MK, Chaudhuri S (2015) T11TS inhibits angiopoietin-1/Tie-2 signaling, EGFR activation and Raf/MEK/ERK pathway in brain endothelial cells restraining angiogenesis in glioma model. Exp Mol Pathol 98:455–466. https://doi.org/10.1016/j.yexmp.2015.03.026

Article  CAS  PubMed  Google Scholar 

Bogdanovic E, Coombs N, Dumont DJ (2009) Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1. Histochem Cell Biol 132:225–237. https://doi.org/10.1007/s00418-009-0603-3

Article  CAS  PubMed  Google Scholar 

Brown C, Gaspar J, Pettit A et al (2004) ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem 279:12794–12803. https://doi.org/10.1074/jbc.M308593200

Article  CAS  PubMed  Google Scholar 

Brunckhorst MK, Wang H, Lu R, Yu Q (2010) Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis. Cancer Res 70:7283–7293. https://doi.org/10.1158/0008-5472.CAN-09-4125

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S, Chen M, Wu X et al (2022) Global, regional and national burden of low back pain 1990–2019: a systematic analysis of the global burden of disease study 2019. J Orthop Translat 32:49–58. https://doi.org/10.1016/j.jot.2021.07.005

Article  CAS  PubMed  Google Scholar 

Cho Y, Jeong S, Kim H et al (2021) Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions. Exp Mol Med 53:1689–1696. https://doi.org/10.1038/s12276-021-00710-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Amico G, Korhonen EA, Anisimov A et al (2014) Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest 124:824–834. https://doi.org/10.1172/JCI68897

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daly C, Wong V, Burova E et al (2004) Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Genes Dev 18:1060–1071. https://doi.org/10.1101/gad.1189704

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daly C, Pasnikowski E, Burova E et al (2006) Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A 103:15491–15496. https://doi.org/10.1073/pnas.0607538103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davis S, Aldrich TH, Jones PF et al (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87:1161–1169. https://doi.org/10.1016/s0092-8674(00)81812-7

Article  CAS  PubMed  Google Scholar 

DeBusk LM, Chen Y, Nishishita T et al (2003) Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum 48:2461–2471. https://doi.org/10.1002/art.11213

Article  CAS  PubMed  Google Scholar 

Del Gaudio F, Liu D, Lendahl U (2022) Notch signalling in healthy and diseased vasculature. Open Biol 12:220004. https://doi.org/10.1098/rsob.220004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng Q, Bai S, Gao W, Tong L (2015) Pristimerin inhibits angiogenesis in adjuvant-induced arthritic rats by suppressing VEGFR2 signaling pathways. Int Immunopharmacol 29:302–313. https://doi.org/10.1016/j.intimp.2015.11.001

Article  CAS  PubMed  Google Scholar 

Dominguez MG, Hughes VC, Pan L et al (2007) Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A 104:3243–3248. https://doi.org/10.1073/pnas.0611510104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eich G, Bartosova M, Tischer C et al (2017) Bicarbonate buffered peritoneal dialysis fluid upregulates angiopoietin-1 and promotes vessel maturation. PLoS ONE 12:e0189903. https://doi.org/10.1371/journal.pone.0189903

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eklund L, Saharinen P (2013) Angiopoietin signaling in the vasculature. Exp Cell Res 319:1271–1280. https://doi.org/10.1016/j.yexcr.2013.03.011

Article  CAS  PubMed  Google Scholar 

El-Sayed RM, Moustafa YM, El-Azab MF (2014) Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. Inflammopharmacology 22:305–317. https://doi.org/10.1007/s10787-014-0200-5

Article  CAS  PubMed  Google Scholar 

Etoh T, Inoue H, Tanaka S et al (2001) Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Res 61:2145–2153

CAS  PubMed  Google Scholar 

Fachinger G, Deutsch U, Risau W (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene 18:5948–5953. https://doi.org/10.1038/sj.onc.1202992

Article  CAS  PubMed  Google Scholar 

Fagiani E, Christofori G (2013) Angiopoietins in angiogenesis. Cancer Lett 328:18–26. https://doi.org/10.1016/j.canlet.2012.08.018

Article  CAS  PubMed  Google Scholar 

Fan F, Stoeltzing O, Liu W et al (2004) Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells. Cancer Res 64:3186–3190. https://doi.org/10.1158/0008-5472.can-03-0407

Article  CAS  PubMed  Google Scholar 

Fearon U, Griosios K, Fraser A et al (2003) Angiopoietins, growth factors, and vascular morphology in early arthritis. J Rheumatol 30:260–268

CAS  PubMed  Google Scholar 

Felcht M, Luck R, Schering A et al (2012) Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest 122:1991–2005. https://doi.org/10.1172/JCI58832

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng Z-T, Yang T, Hou X-Q et al (2019) Sinomenine mitigates collagen-induced arthritis mice by inhibiting angiogenesis. Biomed Pharmacother 113:108759. https://doi.org/10.1016/j.biopha.2019.108759

Article  CAS  PubMed  Google Scholar 

Fiedler U, Krissl T, Koidl S et al (2003) Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem 278:1721–1727. https://doi.org/10.1074/jbc.M208550200

Article  CAS  PubMed  Google Scholar 

Fiedler U, Scharpfenecker M, Koidl S et al (2004) The tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell weibel-palade bodies. Blood 103:4150–4156. https://doi.org/10.1182/blood-2003-10-3685

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