Radiogenomic Profiling for Survival Analysis in Gastric Cancer: Integrating CT Imaging, Gene Expression, and Clinical Data

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer J Clin 68(6):394–424

Google Scholar 

Serra O, Galán M, Ginesta MM, Calvo M, Sala N, Salazar R (2019) Comparison and applicability of molecular classifications for gastric cancer. Cancer Treat Rev 77:29–34

Article  CAS  PubMed  Google Scholar 

Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma: an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64(1):31–49

Article  CAS  PubMed  Google Scholar 

Kwon SJ (2011) Evaluation of the 7th UICC TNM staging system of gastric cancer. J Gastric Cancer 11(2):78–85

Article  PubMed  PubMed Central  Google Scholar 

Tschmelitsch J, Weiser MR, Karpeh MS (2000) Modern staging in gastric cancer. Surg Oncol 9(1):23–30

Article  CAS  PubMed  Google Scholar 

Godfrey EM, Rushbrook SM, Carrol NR (2010) Endoscopic ultrasound: a review of current diagnostic and therapeutic applications. Postgrad Med J 86(1016):346–353

Article  PubMed  Google Scholar 

Layke JC, Lopez PP (2004) Gastric cancer: diagnosis and treatment options. Am Fam Physician 69(5):1133–1141

PubMed  Google Scholar 

Mukherji R, Yin C, Hameed R, Alqahtani AZ, Kulasekaran M, He AR, Weinberg BA, Marshall JL, Hartley ML, Noel MS (2022) The current state of molecular profiling in gastrointestinal malignancies. Biol Direct 17(1):15. https://doi.org/10.1186/s13062-022-00322-0

Koeppel F, Blanchard S, Jovelet C, Genin B, Marcaillou C, Martin E, Rouleau E, Solary E, Soria JC, André F, Lacroix L (2017) Whole exome sequencing for determination of tumor mutation load in liquid biopsy from advanced cancer patients. PloS one 12(11):e0188174

Lo Gullo R, Daimiel I, Morris EA, Pinker K (2020) Combining molecular and imaging metrics in cancer: radiogenomics. Insights Imaging 11:1–17

Article  PubMed  PubMed Central  Google Scholar 

Pinker K, Shitano F, Sala E, Do RK, Young RJ, Wibmer AG, Hricak H, Sutton EJ, Morris EA (2018) Background, current role, and potential applications of radiogenomics. J Magn Reson Imaging 47(3):604–620

Article  PubMed  Google Scholar 

Yeh AC, Li H, Zhu Y, Zhang J, Khramtsova G, Drukker K, Edwards A, McGregor S, Yoshimatsu T, Zheng Y, Niu Q (2019) Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling. Cancer Imaging 19:1–11

Article  CAS  Google Scholar 

Nair JKR, Saeed UA, McDougall CC, Sabri A, Kovacina B, Raidu BVS, Khokhar RA, Probst S, Hirsh V, Chankowsky J, Van Kempen LC (2021) Radiogenomic models using machine learning techniques to predict EGFR mutations in non-small cell lung cancer. Can Assoc Radiol J 72(1):109–119

Article  PubMed  Google Scholar 

Jamshidi N, Diehn M, Bredel M, Kuo MD (2014) Illuminating radiogenomic characteristics of glioblastoma multiforme through integration of MR imaging, messenger RNA expression, and DNA copy number variation. Radiology 270(1):1–2

Article  PubMed  Google Scholar 

Hoshino I, Yokota H, Ishige F, Iwatate Y, Takeshita N, Nagase H, Uno T, Matsubara H (2020) Radiogenomics predicts the expression of microRNA-1246 in the serum of esophageal cancer patients. Sci Rep 10(1):2532

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lucchesi FR, Aredes ND (2016) The Cancer Genome Atlas Stomach Adenocarcinoma Collection (TCGA-STAD) (Version 3). The Cancer Imaging Archive

Fedorov A, Beichel R, Kalpathy-Cramer J, Finet J, Fillion-Robin JC, Pujol S, Bauer C, Jennings D, Fennessy F, Sonka M, Buatti J (2012) 3D Slicer as an image computing platform for the Quantitative Imaging Network. Magn Reson Imaging 30(9):1323–1341

Article  PubMed  PubMed Central  Google Scholar 

Van Griethuysen JJ, Fedorov A, Parmar C, Hosny A, Aucoin N, Narayan V, Beets-Tan RG, Fillion-Robin JC, Pieper S, Aerts HJ (2017) Computational radiomics system to decode the radiographic phenotype. Can Res 77(21):e104–e107

Article  Google Scholar 

Pearson K (1895) VII. Note on regression and inheritance in the case of two parents. Proc R Soc London 58(347–352):240–242

Google Scholar 

Zar JH (2005) Spearman rank correlation. Encyclopedia of Biostatistics 7. https://doi.org/10.1002/0470011815.b2a15150

Spearman C (1961) The proof and measurement of association between two things. In: Jenkins JJ, Paterson DG (eds) Studies in individual differences: the search for intelligence. Appleton-Century-Crofts, pp 45–58. https://doi.org/10.1037/11491-005

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci 102(43):15545–15550

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali Abd Al-Hameed K (2022) Spearman’s correlation coefficient in statistical analysis. Int J Nonlinear Anal Appl 13(1):3249–3255

Google Scholar 

Clark TG, Bradburn MJ, Love SB, Altman DG (2003) Survival analysis part I: basic concepts and first analyses. Br J Cancer 89(2):232–238

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wijethilake N, Islam M, Ren H (2020) Radiogenomics model for overall survival prediction of glioblastoma. Med Biol Eng Compu 58:1767–1777

Article  Google Scholar 

Pedregosa F (2011) Scikit-learn: Machine learning in python Fabian. J Mach Learn Res 12:2825

Google Scholar 

Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hussain SP, Amstad P, Raja K, Ambs S, Nagashima M, Bennett WP, Shields PG, Ham AJ, Swenberg JA, Marrogi AJ, Harris CC (2000) Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Can Res 60(13):3333–3337

CAS  Google Scholar 

Fridman WH, Pagès F, Sautès-Fridman C, Galon J (2012) The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 12(4):298–306

Article  CAS  PubMed  Google Scholar 

Park C, Cho J, Lee J, Kang SY, An JY, Choi MG, Lee JH, Sohn TS, Bae JM, Kim S, Kim ST (2017) Host immune response index in gastric cancer identified by comprehensive analyses of tumor immunity. Oncoimmunology 6(11):e1356150

Article  PubMed  PubMed Central  Google Scholar 

Colombo MP, Trinchieri G (2002) Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev 13(2):155–168

Article  CAS  PubMed  Google Scholar 

Nicholson SE, Keating N, Belz GT (2019) Natural killer cells and anti-tumor immunity. Mol Immunol 110:40–47

Article  CAS  PubMed  Google Scholar 

Appert-Collin A, Hubert P, Crémel G, Bennasroune A (2015) Role of ErbB receptors in cancer cell migration and invasion. Front Pharmacol 6:283

Article  PubMed  PubMed Central  Google Scholar 

Gutiérrez-Hoya A, Soto-Cruz I (2020) Role of the JAK/STAT pathway in cervical cancer: its relationship with HPV E6/E7 oncoproteins. Cells 9(10):2297

Article  PubMed  PubMed Central  Google Scholar 

Sadras F, Monteith GR, Roberts-Thomson SJ (2021) An emerging role for calcium signaling in cancer-associated fibroblasts. Int J Mol Sci 22(21):11366

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao J, Xiong S, Klos K, Nguyen N, Grijalva R, Li P, Yu D (2001) Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-β1 in human breast cancer cells. Oncogene 20(56):8066–8074

Article  CAS  PubMed  Google Scholar 

Lei ZN, Teng QX, Tian Q, Chen W, Xie Y, Wu K, Zeng Q, Zeng L, Pan Y, Chen ZS, He Y (2022) Signaling pathways and therapeutic interventions in gastric cancer. Signal Transduct Target Ther 7(1):358

Article  PubMed  PubMed Central  Google Scholar 

Fathi D, Elballal MS, Elesawy AE, Abulsoud AI, Elshafei A, Elsakka EG, Ismail A, El-Mahdy HA, Elrebehy MA, Doghish AS (2023) An emphasis on the interaction of signaling pathways highlights the role of miRNAs in the etiology and treatment resistance of gastric cancer. Life Sci 322:121667

Article  CAS 

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