Implementation of the 2022 AAP guidelines for neonatal hyperbilirubinemia could reduce the need for phototherapy in Italy

Le Pichon JB, Riordan SM, Watchko J, Shapiro SM. The neurological sequelae of neonatal hyperbilirubinemia: definitions, diagnosis and treatment of the Kernicterus spectrum disorders (KSDs). Curr Pediatr Rev. 2017;13:199–209.

PubMed  Google Scholar 

Romagnoli C, Barone G, Pratesi S, Raimondi F, Capasso L, Zecca E, et al. Italian guidelines for management and treatment of hyperbilirubinaemia of newborn infants ≥ 35 weeks’ gestational age. Ital J Pediatr. 2014;31:40:11.

Article  Google Scholar 

American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114:297–316.

Article  Google Scholar 

Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps DL, O’Shea TM, et al. NICHD neonatal research network. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008;359:1885–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stevenson DK, Wong RJ, Arnold CC, Pedroza C, Tyson JE. Phototherapy and the risk of photo-oxidative injury in extremely low birth weight infants. Clin Perinatol. 2016;43:291–5.

Article  PubMed  Google Scholar 

Shekeeb Shahab M, Kumar P, Sharma N, Narang A, Prasad R. Evaluation of oxidant and antioxidant status in term neonates: a plausible protective role of bilirubin. Mol Cell Biochem. 2008;317:51–9.

Article  CAS  PubMed  Google Scholar 

Kurt A, Aygun AD, Kurt ANC, Godekmerdan A, Akarsu S, Yilmaz E. Use of phototherapy for neonatal hyperbilirubinemia affects cytokine production and lymphocyte subsets. Neonatology. 2009;95:262–6.

Article  CAS  PubMed  Google Scholar 

Nandraziova L, Matasova K, Gumulak R. Phototherapy and its effect on some physiological functions in newborns. ACTA Med Martiniana. 2018;18:5–13.

Article  Google Scholar 

Benders MJ, van Bel F, van de Bor M. The effect of phototherapy on cerebral blood flow velocity in preterm infants. Acta Paediatr. 1998;87:786–91.

Article  CAS  PubMed  Google Scholar 

Yao AC, Martinussen M, Johansen OJ, Brubakk AM. Phototherapy-associated changes in mesenteric blood flow response to feeding in term neonates. J Pediatr. 1994;124:309–12.

Article  CAS  PubMed  Google Scholar 

Dani C, Ciarcià M, Miselli F, Luzzati M, Petrolini C, Corsini I, et al. Splanchnic oxygenation during phototherapy in preterm infants with hyperbilirubinemia. Early Hum Dev. 2022;173:105662.

Article  CAS  PubMed  Google Scholar 

Dani C, Ciarcià M, Luzzati M, Nardecchia S, Petrolini C, Sarli WM, et al. Feeding intolerance during phototherapy in preterm infants. J Matern Fetal Neonatal Med. 2022;35:4.

Article  Google Scholar 

Aouthmany MM. Phototherapy increases hemoglobin degradation and bilirubin production in preterm infants. J Perinatol. 1999;19:271–4.

Article  CAS  PubMed  Google Scholar 

Karakukcu C, Ustdal M, Ozturk A, Baskol G, Saraymen R. Assessment of DNA damage and plasma catalase activity in healthy term hyperbilirubinemic infants receiving phototherapy. Mutat Res. 2009;680:12–6.

Article  CAS  PubMed  Google Scholar 

Ramy N, Ghany EA, AlsharanyW, Nada A, Darwish RK, Rabie WA, et al. Jaundice, phototherapy and DNA damage in full-term neonates. J Perinatol. 2016;36:132–6.

Article  CAS  PubMed  Google Scholar 

Yahia S, Shabaan AE, Gouida M, El-Ghanam D, Eldegla H, El-Bakary A, et al. Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants. Eur J Pediatr. 2015;174:459–64.

Article  CAS  PubMed  Google Scholar 

Karadag A, Yesilyurt A, Unal S, Keskin I, Demirin H, Uras N, et al. A chromosomal-effect study of intensive phototherapy versus conventional phototherapy in newborns with jaundice. Mutat Res. 2009;676:17–20.

Article  CAS  PubMed  Google Scholar 

Tozzi E, Tozzi-Ciancarelli MG, Di Giulio A, D’Alfonso A, Farello G, Spennati GF, et al. In vitro and in vivo effects of erythrocyte phototherapy on newborns. Biol Neonate. 1989;56:204–9.

Article  CAS  PubMed  Google Scholar 

Maimburg RD, Olsen J, Sun Y. Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. Epilepsy Res. 2016;124:67–72.

Article  CAS  PubMed  Google Scholar 

Newman TB, Wu YW, Kuzniewicz MW, Grimes BA, McCulloch CE. Childhood seizures after phototherapy. Pediatrics. 2018;142:e20180648.

Article  PubMed  Google Scholar 

Wickremasinghe AC, Kuzniewicz MW, Grimes BA, McCulloch CE, Newman TB. Neonatal phototherapy and infantile cancer. Pediatrics. 2016;137:e20151353.

Article  PubMed  Google Scholar 

Newman TB, Wickremasinghe AC, Walsh EM, Grimes BA, McCulloch CE, Kuzniewicz MW. Retrospective cohort study of phototherapy and childhood cancer in Northern California. Pediatrics. 2016;137:e20151354.

Article  PubMed  Google Scholar 

Tyson JE, Miller CC. Whether neonatal phototherapy increases the risk of cancer in children is a disturbing unresolved issue. Evid Based Med. 2017;22:39–40.

Article  PubMed  Google Scholar 

Landman G, Hoffman K, Sun Y, UCSF Northern California Neonatal Consortium (NCNC). Consensus guidelines for screening & management of hyperbilirubinemia in neonates. Available at: https://www.ucsfbenioffchildrens.org/-/media/project/ucsf/ucsfbch/ pdf/hyperbilirubinemia_consensu consensus_guideline.pdf

Kuzniewicz MW, Escobar GJ, Wi S, Liljestrand P, McCulloch C, Newman TB. Risk factors for severe hyperbilirubinemia among infants with borderline bilirubin levels: a nested case-control study. J Pediatr. 2008;153:234–40.

Article  PubMed  PubMed Central  Google Scholar 

Kuzniewicz MW, Park J, Niki H, Walsh EM, McCulloch CE, Newman TB. Predicting the need for phototherapy after discharge. Pediatrics. 2021;147:e2020019778.

Article  PubMed  Google Scholar 

Kemper AR, Newman TB, Slaughter JL, Maisels MJ, Watchko JF, Downs SM, et al. Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2022;150:e2022058859.

Article  PubMed  Google Scholar 

Sarathy L, Chou JH, Romano-Clarke G, Darci KA, Lerou PH. Bilirubin measurement and phototherapy use after the AAP 2022 newborn hyperbilirubinemia guideline. Pediatrics. 2024;153:e2023063323.

Article  PubMed  Google Scholar 

Michienzi MR, Tomasini DK, Fisher CC, Ponnapakkam AP. Implementation of the revised American academy of pediatrics clinical practice guidelines for hyperbilirubinemia decreases necessity for serum bilirubin and phototherapy. Jt Comm J Qual Patient Saf 2024;1:S1553-7250(24)00328-3.

Dani C, Becciani S, Pratesi S. Changes in total serum bilirubin during phototherapy in late preterm and term infants with non-haemolytic hyperbilirubinemia. Early Hum Dev. 2019;131:41–4.

Article  CAS  PubMed  Google Scholar 

Bergman NJ. Birth practices. Maternal-neonate separation as a source of toxic stress. Birth Defects Res. 2019;111:1087–109.

Article  CAS  PubMed  Google Scholar 

Patriksson K, Selin L. Parents and newborn togetherness after birth. Int J Qual Stud Health Well-being. 2022;17:2026281.

Article  PubMed  PubMed Central  Google Scholar 

Battersby C, Michaelides S, Upton M, Rennie JM. Term admissions to neonatal units in England: a role for transitional care? A retrospective cohort study. BMJ Open. 2017;7:e016050.

Article  PubMed  PubMed Central  Google Scholar 

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