Synthesis of Autotaxin-Inhibiting Lipid Nanoparticles to Regulate Autophagy and Inflammatory Responses in Activated Macrophages

Stracke M, Krutzsch HC, Unsworth EJ, Arestad A, Cioce V, Schiffmann E, et al. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem. 1992;267:2524–9.

Article  CAS  PubMed  Google Scholar 

Perrakis A, Moolenaar WH. Autotaxin: structure-function and signaling. J Lipid Res. 2014;55:1010–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tokumura A, Majima E, Kariya Y, Tominaga K, Kogure K, Yasuda K, et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem. 2002;277:39436–42.

Article  CAS  PubMed  Google Scholar 

Tsuchida Y, Shoda H, Sawada T, Fujio K. Role of autotaxin in systemic lupus erythematosus. Front Med. 2023;10:1166343.

Article  Google Scholar 

Federico L, Ren H, Mueller PA, Wu T, Liu S, Popovic J, et al. Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol. 2012;26:786–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gierse J, Thorarensen A, Beltey K, Bradshaw-Pierce E, Cortes-Burgos L, Hall T, et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther. 2010;334:310–7.

Article  CAS  PubMed  Google Scholar 

Gotoh M, Fujiwara Y, Yue J, Liu J, Lee S, Fells J, et al. Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis. Biochem Soc Trans. 2012;40:31–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Corven EJ, Groenink A, Jalink K, Eichholtz T, Moolenaar WH. Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. Cell. 1989;59:45–54.

Article  PubMed  Google Scholar 

Zhang X, Li M, Yin N, Zhang J. The expression regulation and biological function of autotaxin. Cells. 2021;10:939.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magkrioti C, Galaris A, Kanellopoulou P, Stylianaki E-A, Kaffe E, Aidinis V. Autotaxin and chronic inflammatory diseases. J Autoimmun. 2019;104: 102327.

Article  CAS  PubMed  Google Scholar 

Lee HY, Bae GU, Jung ID, Lee JS, Kim YK, Noh SH, et al. Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase γ in human melanoma cells. FEBS Lett. 2002;515:137–40.

Article  CAS  PubMed  Google Scholar 

Liu S, Murph M, Panupinthu N, Mills GB. ATX-LPA receptor axis in inflammation and cancer. Cell Cycle. 2009;8:3695–701.

Article  CAS  PubMed  Google Scholar 

Salgado-Polo F, Borza R, Matsoukas M-T, Marsais F, Jagerschmidt C, Waeckel L, et al. Autotaxin facilitates selective LPA receptor signaling. Cell Chem Biol. 2023;30:69-8414.e14.

Article  CAS  PubMed  Google Scholar 

Liao Y, Liu L, Yang J, Shi Z. ATX/LPA axis regulates FAK activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells. In Vitro Cell Dev Biol Anim. 2022;58:307–15.

Article  CAS  PubMed  Google Scholar 

Okudaira S, Yukiura H, Aoki J. Biological roles of lysophosphatidic acid signaling through its production by autotaxin. Biochimie. 2010;92:698–706.

Article  CAS  PubMed  Google Scholar 

Abdel-Latif A, Heron PM, Morris AJ, Smyth SS. Lysophospholipids in coronary artery and chronic ischemic heart disease. Curr Opin Lipidol. 2015;26:432–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010;62:579–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oikonomou N, Mouratis M-A, Tzouvelekis A, Kaffe E, Valavanis C, Vilaras G, et al. Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Cell Mol Biol. 2012;47:566–74.

Article  PubMed  Google Scholar 

Van Meeteren LA, Moolenaar WH. Regulation and biological activities of the autotaxin–LPA axis. Prog Lipid Res. 2007;46:145–60.

Article  PubMed  Google Scholar 

Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, et al. Autophagy in healthy aging and disease. Nat Aging. 2021;1:634–50.

Article  PubMed  PubMed Central  Google Scholar 

Awada R, Saulnier-Blache JS, Grès S, Bourdon E, Rondeau P, Parimisetty A, et al. Autotaxin downregulates LPS-induced microglia activation and pro-inflammatory cytokines production. J Cell Biochem. 2014;115:2123–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ninou I, Kaffe E, Müller S, Budd DC, Stevenson CS, Ullmer C, et al. Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis. Pulm Pharmacol Ther. 2018;52:32–40.

Article  CAS  PubMed  Google Scholar 

Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, et al. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci. 2010;107:7257–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gupte R, Patil R, Liu J, Wang Y, Lee SC, Fujiwara Y, et al. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity. Chem Med Chem. 2011;6:922–35.

Article  CAS  PubMed  Google Scholar 

Tigyi GJ, Yue J, Norman DD, Szabo E, Balogh A, Balazs L, et al. Regulation of tumor cell–Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis. Adv Biol Regul. 2019;71:183–93.

Article  CAS  PubMed  Google Scholar 

Leblanc R, Lee SC, David M, Bordet JC, Norman DD, Patil R, et al. Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. Blood J Am Soc Hematol. 2014;124:3141–50.

CAS  Google Scholar 

Sohn HS, Choi JW, Jhun J, Kwon SP, Jung M, Yong S, et al. Tolerogenic nanoparticles induce type II collagen–specific regulatory T cells and ameliorate osteoarthritis. Sci Adv. 2022;8:eabo5284.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobersalske C, Grundmann M, Timmermann A, Theisen L, Kölling F, Harris RC, et al. Establishment of a novel, cell-based autotaxin assay. Anal Biochem. 2021;630:114322.

Article  CAS  PubMed  Google Scholar 

North EJ, Howard AL, Wanjala IW, Pham TCT, Baker DL, Parrill AL. Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors. J Med Chem. 2010;53:3095–105.

Article  CAS  PubMed  Google Scholar 

Zhou F, Mei J, Yang S, Han X, Li H, Yu Z, et al. Modified ZIF-8 nanoparticles attenuate osteoarthritis by reprogramming the metabolic pathway of synovial macrophages. ACS Appl Mater Interfaces. 2019;12:2009–22.

Article  PubMed  Google Scholar 

Li H, Yuan Y, Zhang L, Xu C, Xu H, Chen Z. Reprogramming macrophage polarization, depleting ROS by Astaxanthin and Thioketal-containing polymers delivering rapamycin for osteoarthritis treatment. Adv Sci. 2024;11:2305363.

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