Stracke M, Krutzsch HC, Unsworth EJ, Arestad A, Cioce V, Schiffmann E, et al. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem. 1992;267:2524–9.
Article CAS PubMed Google Scholar
Perrakis A, Moolenaar WH. Autotaxin: structure-function and signaling. J Lipid Res. 2014;55:1010–8.
Article CAS PubMed PubMed Central Google Scholar
Tokumura A, Majima E, Kariya Y, Tominaga K, Kogure K, Yasuda K, et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem. 2002;277:39436–42.
Article CAS PubMed Google Scholar
Tsuchida Y, Shoda H, Sawada T, Fujio K. Role of autotaxin in systemic lupus erythematosus. Front Med. 2023;10:1166343.
Federico L, Ren H, Mueller PA, Wu T, Liu S, Popovic J, et al. Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol. 2012;26:786–97.
Article CAS PubMed PubMed Central Google Scholar
Gierse J, Thorarensen A, Beltey K, Bradshaw-Pierce E, Cortes-Burgos L, Hall T, et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther. 2010;334:310–7.
Article CAS PubMed Google Scholar
Gotoh M, Fujiwara Y, Yue J, Liu J, Lee S, Fells J, et al. Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis. Biochem Soc Trans. 2012;40:31–6.
Article CAS PubMed PubMed Central Google Scholar
van Corven EJ, Groenink A, Jalink K, Eichholtz T, Moolenaar WH. Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. Cell. 1989;59:45–54.
Zhang X, Li M, Yin N, Zhang J. The expression regulation and biological function of autotaxin. Cells. 2021;10:939.
Article CAS PubMed PubMed Central Google Scholar
Magkrioti C, Galaris A, Kanellopoulou P, Stylianaki E-A, Kaffe E, Aidinis V. Autotaxin and chronic inflammatory diseases. J Autoimmun. 2019;104: 102327.
Article CAS PubMed Google Scholar
Lee HY, Bae GU, Jung ID, Lee JS, Kim YK, Noh SH, et al. Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase γ in human melanoma cells. FEBS Lett. 2002;515:137–40.
Article CAS PubMed Google Scholar
Liu S, Murph M, Panupinthu N, Mills GB. ATX-LPA receptor axis in inflammation and cancer. Cell Cycle. 2009;8:3695–701.
Article CAS PubMed Google Scholar
Salgado-Polo F, Borza R, Matsoukas M-T, Marsais F, Jagerschmidt C, Waeckel L, et al. Autotaxin facilitates selective LPA receptor signaling. Cell Chem Biol. 2023;30:69-8414.e14.
Article CAS PubMed Google Scholar
Liao Y, Liu L, Yang J, Shi Z. ATX/LPA axis regulates FAK activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells. In Vitro Cell Dev Biol Anim. 2022;58:307–15.
Article CAS PubMed Google Scholar
Okudaira S, Yukiura H, Aoki J. Biological roles of lysophosphatidic acid signaling through its production by autotaxin. Biochimie. 2010;92:698–706.
Article CAS PubMed Google Scholar
Abdel-Latif A, Heron PM, Morris AJ, Smyth SS. Lysophospholipids in coronary artery and chronic ischemic heart disease. Curr Opin Lipidol. 2015;26:432–7.
Article CAS PubMed PubMed Central Google Scholar
Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010;62:579–87.
Article CAS PubMed PubMed Central Google Scholar
Oikonomou N, Mouratis M-A, Tzouvelekis A, Kaffe E, Valavanis C, Vilaras G, et al. Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Cell Mol Biol. 2012;47:566–74.
Van Meeteren LA, Moolenaar WH. Regulation and biological activities of the autotaxin–LPA axis. Prog Lipid Res. 2007;46:145–60.
Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, et al. Autophagy in healthy aging and disease. Nat Aging. 2021;1:634–50.
Article PubMed PubMed Central Google Scholar
Awada R, Saulnier-Blache JS, Grès S, Bourdon E, Rondeau P, Parimisetty A, et al. Autotaxin downregulates LPS-induced microglia activation and pro-inflammatory cytokines production. J Cell Biochem. 2014;115:2123–32.
Article CAS PubMed PubMed Central Google Scholar
Ninou I, Kaffe E, Müller S, Budd DC, Stevenson CS, Ullmer C, et al. Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis. Pulm Pharmacol Ther. 2018;52:32–40.
Article CAS PubMed Google Scholar
Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, et al. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci. 2010;107:7257–62.
Article CAS PubMed PubMed Central Google Scholar
Gupte R, Patil R, Liu J, Wang Y, Lee SC, Fujiwara Y, et al. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity. Chem Med Chem. 2011;6:922–35.
Article CAS PubMed Google Scholar
Tigyi GJ, Yue J, Norman DD, Szabo E, Balogh A, Balazs L, et al. Regulation of tumor cell–Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis. Adv Biol Regul. 2019;71:183–93.
Article CAS PubMed Google Scholar
Leblanc R, Lee SC, David M, Bordet JC, Norman DD, Patil R, et al. Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. Blood J Am Soc Hematol. 2014;124:3141–50.
Sohn HS, Choi JW, Jhun J, Kwon SP, Jung M, Yong S, et al. Tolerogenic nanoparticles induce type II collagen–specific regulatory T cells and ameliorate osteoarthritis. Sci Adv. 2022;8:eabo5284.
Article CAS PubMed PubMed Central Google Scholar
Dobersalske C, Grundmann M, Timmermann A, Theisen L, Kölling F, Harris RC, et al. Establishment of a novel, cell-based autotaxin assay. Anal Biochem. 2021;630:114322.
Article CAS PubMed Google Scholar
North EJ, Howard AL, Wanjala IW, Pham TCT, Baker DL, Parrill AL. Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors. J Med Chem. 2010;53:3095–105.
Article CAS PubMed Google Scholar
Zhou F, Mei J, Yang S, Han X, Li H, Yu Z, et al. Modified ZIF-8 nanoparticles attenuate osteoarthritis by reprogramming the metabolic pathway of synovial macrophages. ACS Appl Mater Interfaces. 2019;12:2009–22.
Li H, Yuan Y, Zhang L, Xu C, Xu H, Chen Z. Reprogramming macrophage polarization, depleting ROS by Astaxanthin and Thioketal-containing polymers delivering rapamycin for osteoarthritis treatment. Adv Sci. 2024;11:2305363.
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