Trefts E, Gannon M, Wasserman DH. The liver. Curr Biol. 2017;27:R1147–51.
Article CAS PubMed PubMed Central Google Scholar
Sharma A, Nagalli S. Chronic liver disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.
Younossi ZM, Golabi P, Paik JM, Henry A, Van Dongen C, Henry L. The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Hepatology. 2023;77:1335–47.
Cheemerla S, Balakrishnan M. Global epidemiology of chronic liver disease. Clin Liver Dis (Hoboken). 2021;17:365–70.
Jung YK, Yim HJ. Reversal of liver cirrhosis: current evidence and expectations. Korean J Intern Med. 2017;32:213–28.
Article CAS PubMed PubMed Central Google Scholar
Bayarsaikhan D, Bayarsaikhan G, Kang HA, Lee SB, Han SH, Okano T, et al. A study on iPSC-associated factors in the generation of hepatocytes. Tissue Eng Regen Med. 2024;21:1245–54.
Article CAS PubMed Google Scholar
Kim JH, Jang YJ, An SY, Son J, Lee J, Lee G, et al. Enhanced metabolizing activity of human ES cell-derived hepatocytes using a 3D culture system with repeated exposures to xenobiotics. Toxicol Sci. 2015;147:190–206.
Article CAS PubMed Google Scholar
Park JY, Han J, Jung HS, Lee G, Kim HJ, Cho GS, et al. Synthetic probes for in vitro purification and in vivo tracking of hepatocytes derived from human pluripotent stem cells. Biomaterials. 2019;222: 119431.
Article CAS PubMed Google Scholar
Duval K, Grover H, Han LH, Mou Y, Pegoraro AF, Fredberg J, et al. Modeling physiological events in 2D vs. 3D cell culture. Physiology (Bethesda). 2017;32:266–77.
Lancaster MA, Knoblich JA. Organogenesis in a dish: modeling development and disease using organoid technologies. Science. 2014;345:1247125.
Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115:209–18.
Article CAS PubMed PubMed Central Google Scholar
Friedman SL. Liver fibrosis – from bench to bedside. J Hepatol. 2003;38:S38-53.
Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021;18:151–66.
Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14:397–411.
Article CAS PubMed Google Scholar
Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 2008;88:125–72.
Article CAS PubMed Google Scholar
Chen K, Xu M, Lu F, He Y. Development of matrix metalloproteinases-mediated extracellular matrix remodeling in regenerative medicine: a mini review. Tissue Eng Regen Med. 2023;20:661–70.
Article CAS PubMed PubMed Central Google Scholar
Chen L, Brenner DA, Kisseleva T. Combatting fibrosis: exosome-based therapies in the regression of liver fibrosis. Hepatol Commun. 2018;3:180–92.
Article PubMed PubMed Central Google Scholar
Xu AL, Han L, Yan J, Liu D, Wang W. Effects of mesenchymal stem cells-derived extracellular vesicles on inhibition of hepatic fibrosis by delivering miR-200a. Tissue Eng Regen Med. 2024;21:609–24.
Article CAS PubMed PubMed Central Google Scholar
Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture. Hepatology. 1992;15:234–43.
Article CAS PubMed Google Scholar
Lee G, Kim H, Park JY, Kim G, Han J, Chung S, et al. Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis. Biomaterials. 2021;269:120529.
Article CAS PubMed Google Scholar
Lee DH, Yun DW, Kim YH, Im GB, Hyun J, Park HS, et al. Various three-dimensional culture methods and cell types for exosome production. Tissue Eng Regen Med. 2023;20:621–35.
Article CAS PubMed PubMed Central Google Scholar
Brovold M, Keller D, Soker S. Differential fibrotic phenotypes of hepatic stellate cells within 3D liver organoids. Biotechnol Bioeng. 2020;117:2516–26.
Article CAS PubMed PubMed Central Google Scholar
Mannaerts I, Thoen LFR, Eysackers N, Cubero FJ, Leite SB, Coldham I, et al. Unfolded protein response is an early, non-critical event during hepatic stellate cell activation. Cell Death Dis. 2019;10:98.
Article PubMed PubMed Central Google Scholar
Sorrentino G, Rezakhani S, Yildiz E, Nuciforo S, Heim MH, Lutolf MP, et al. Mechano-modulatory synthetic niches for liver organoid derivation. Nat Commun. 2020;11:3416.
Article CAS PubMed PubMed Central Google Scholar
Septiana WL, Pawitan JA. Potential use of organoids in regenerative medicine. Tissue Eng Regen Med. 2024;21:1125–39.
Kammerer S. Three-dimensional liver culture systems to maintain primary hepatic properties for toxicological analysis in vitro. Int J Mol Sci. 2021;22:10214.
Article CAS PubMed PubMed Central Google Scholar
Lee SY, Koo IS, Hwang HJ, Lee DW. In vitro three-dimensional (3D) cell culture tools for spheroid and organoid models. SLAS Discov. 2023;28:119–37.
Article CAS PubMed Google Scholar
Urzi O, Gasparro R, Costanzo E, De Luca A, Giavaresi G, Fontana S, et al. Three-dimensional cell cultures: the bridge between in vitro and in vivo models. Int J Mol Sci. 2023;24:12046.
Article CAS PubMed PubMed Central Google Scholar
Juarez-Moreno K, Chavez-Garcia D, Hirata G, Vazquez-Duhalt R. Monolayer (2D) or spheroids (3D) cell cultures for nanotoxicological studies? Comparison of cytotoxicity and cell internalization of nanoparticles. Toxicol In Vitro. 2022;85:105461.
Article CAS PubMed Google Scholar
Zhu T, Hu Y, Cui H, Cui H. 3D multispheroid assembly strategies towards tissue engineering and disease modeling. Adv Healthc Mater. 2024;13:e2400957.
Zhang CY, Yuan WG, He P, Lei JH, Wang CX. Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets. World J Gastroenterol. 2016;22:10512–22.
Article CAS PubMed PubMed Central Google Scholar
Leite SB, Roosens T, El Taghdouini A, Mannaerts I, Smout AJ, Najimi M, et al. Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials. 2016;78:1–10.
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