Cahill TJ, Choudhury RP, Riley PR. Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics. Nat Rev Drug Discov. 2017;16:699–717.
Article CAS PubMed Google Scholar
Karbassi E, Fenix A, Marchiano S, Muraoka N, Nakamura K, Yang X, et al. Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine. Nat Rev Cardiol. 2020;17:341–59.
Article PubMed PubMed Central Google Scholar
Dhahri W, Sadikov Valdman T, Wilkinson D, Pereira E, Ceylan E, Andharia N, et al. In vitro matured human pluripotent stem cell-derived cardiomyocytes form grafts with enhanced structure and function in injured hearts. Circulation. 2022;145:1412–26.
Article CAS PubMed Google Scholar
Ewoldt JK, DePalma SJ, Jewett ME, Karakan MC, Lin YM, Mir Hashemian P, et al. Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challenges. Nat Methods. 2025;22:24–40.
Article CAS PubMed Google Scholar
Yang X, Rodriguez M, Pabon L, Fischer KA, Reinecke H, Regnier M, et al. Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells. J Mol Cell Cardiol. 2014;72:296–304.
Article CAS PubMed PubMed Central Google Scholar
Miao S, Zhao D, Wang X, Ni X, Fang X, Yu M, et al. Retinoic acid promotes metabolic maturation of human embryonic stem cell-derived cardiomyocytes. Theranostics. 2020;10:9686–701.
Article CAS PubMed PubMed Central Google Scholar
Yang X, Rodriguez ML, Leonard A, Sun L, Fischer KA, Wang Y, et al. Fatty acids enhance the maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cell Rep. 2019;13:657–68.
Correia C, Koshkin A, Duarte P, Hu D, Teixeira A, Domian I, et al. Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Sci Rep. 2017;7:8590.
Article CAS PubMed PubMed Central Google Scholar
Kim YS, Yoon JW, Kim D, Choi S, Kim HK, Youm JB, et al. Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction. Exp Mol Med. 2022;54:493–502.
Article CAS PubMed PubMed Central Google Scholar
Shen N, Knopf A, Westendorf C, Kraushaar U, Riedl J, Bauer H, et al. Steps toward maturation of embryonic stem cell-derived cardiomyocytes by defined physical signals. Stem Cell Rep. 2017;9:122–35.
Ronaldson-Bouchard K, Ma SP, Yeager K, Chen T, Song L, Sirabella D, et al. Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature. 2018;556:239–43.
Article CAS PubMed PubMed Central Google Scholar
Lu K, Seidel T, Cao-Ehlker X, Dorn T, Batcha AMN, Schneider CM, et al. Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium. Theranostics. 2021;11:6138–53.
Article CAS PubMed PubMed Central Google Scholar
Nunes SS, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, et al. Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat Methods. 2013;10:781–7.
Article CAS PubMed PubMed Central Google Scholar
Crestani T, Steichen C, Neri E, Rodrigues M, Fonseca-Alaniz MH, Ormrod B, et al. Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells. Biochem Biophys Res Commun. 2020;533:376–82.
Article CAS PubMed Google Scholar
Cui C, Wang J, Qian D, Huang J, Lin J, Kingshott P, et al. Binary colloidal crystals drive spheroid formation and accelerate maturation of human-induced pluripotent stem cell-derived cardiomyocytes. ACS Appl Mater Interfaces. 2019;11:3679–89.
Article CAS PubMed Google Scholar
Wang J, Cui C, Nan H, Yu Y, Xiao Y, Poon E, et al. Graphene sheet-induced global maturation of cardiomyocytes derived from human induced pluripotent stem cells. ACS Appl Mater Interfaces. 2017;9:25929–40.
Article CAS PubMed Google Scholar
Xu C, Wang L, Yu Y, Yin F, Zhang X, Jiang L, et al. Bioinspired onion epithelium-like structure promotes the maturation of cardiomyocytes derived from human pluripotent stem cells. Biomater Sci. 2017;5:1810–9.
Article CAS PubMed Google Scholar
Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, Escalante GO, et al. Inhibition of mTOR signaling enhances maturation of cardiomyocytes derived from human-induced pluripotent stem cells via p53-induced quiescence. Circulation. 2020;141:285–300.
Article CAS PubMed Google Scholar
Sakamoto T, Matsuura TR, Wan S, Ryba DM, Kim JU, Won KJ, et al. A critical role for estrogen-related receptor signaling in cardiac maturation. Circ Res. 2020;126:1685–702.
Article CAS PubMed PubMed Central Google Scholar
Miki K, Deguchi K, Nakanishi-Koakutsu M, Lucena-Cacace A, Kondo S, Fujiwara Y, et al. ERRgamma enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes. Nat Commun. 2021;12:3596.
Article CAS PubMed PubMed Central Google Scholar
Hu D, Linders A, Yamak A, Correia C, Kijlstra JD, Garakani A, et al. Metabolic maturation of human pluripotent stem cell-derived cardiomyocytes by inhibition of HIF1alpha and LDHA. Circ Res. 2018;123:1066–79.
Article CAS PubMed PubMed Central Google Scholar
Hodgkinson CP, Pratt RE, Kirste I, Dal-Pra S, Cooke JP, Dzau VJ. Cardiomyocyte maturation requires TLR3 activated nuclear factor Kappa B. Stem Cells. 2018;36:1198–209.
Article CAS PubMed Google Scholar
Ng DCH, Richards DK, Mills RJ, Ho UY, Perks HL, Tucker CR, et al. Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Rep. 2020;15:817–26.
Wickramasinghe NM, Sachs D, Shewale B, Gonzalez DM, Dhanan-Krishnan P, Torre D, et al. PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell. 2022;29:559–76.
Article CAS PubMed PubMed Central Google Scholar
Liu W, Zhao N, Yin Q, Zhao X, Guo K, Xian Y, et al. Injectable hydrogels encapsulating dual-functional Au@Pt core-shell nanoparticles regulate infarcted microenvironments and enhance the therapeutic efficacy of stem cells through antioxidant and electrical integration. ACS Nano. 2023;17:2053–66.
Article CAS PubMed PubMed Central Google Scholar
He W, Liu Y, Yuan J, Yin JJ, Wu X, Hu X, et al. Au@Pt nanostructures as oxidase and peroxidase mimetics for use in immunoassays. Biomaterials. 2011;32:1139–47.
Article CAS PubMed Google Scholar
Liang J, Wu M, Chen C, Mai M, Huang J, Zhu P. Roles of reactive oxygen species in cardiac differentiation, reprogramming, and regenerative therapies. Oxid Med Cell Longev. 2020;2020:2102841.
Article CAS PubMed PubMed Central Google Scholar
Momtahan N, Crosby CO, Zoldan J. The role of reactive oxygen species in in vitro cardiac maturation. Trends Mol Med. 2019;25:482–93.
Comments (0)