Atrial fibrillation and ischemic stroke in cancer: the latest scientific evidence, current management, and future directions

Iwasaki Y, Nishida K, Kato T, Nattel S (2011) Atrial fibrillation pathophysiology: implications for management. Circulation 124:2264–2274

Article  CAS  PubMed  Google Scholar 

Linz D, Gawalko M, Betz K, Hendriks JM, Lip GYH, Vinter N, Guo Y, Johnsen S (2024) Atrial fibrillation: epidemiology, screening and digital health. Lancet Reg Health - Europe 37:100786

Article  PubMed  Google Scholar 

Zoni-Berisso M, Lercari F, Carazza T, Domenicucci S (2014) Epidemiology of atrial fibrillation: European perspective. Clin Epidemiol 6:213–220

Article  PubMed  PubMed Central  Google Scholar 

Jones NR, Taylor CJ, Hobbs FDR, Bowman L, Casadei B (2020) Screening for atrial fibrillation: a call for evidence. Eur Heart J 41:1075–1085

Article  PubMed  Google Scholar 

Yun JP, Choi E-K, Han K-D, Park SH, Jung J-H, Park SH, Ahn H-J, Lim J-H, Lee S-R, Oh S (2021) Risk of atrial fibrillation according to Cancer type. JACC: CardioOncology 3:221–232

PubMed  PubMed Central  Google Scholar 

Khamis A, Shaban AE, Altamimi TS, Shkoukani ZW, Hamam I (2022) Atrial fibrillation in cancer patients who develop stroke. Cardio-Oncology 8:12

Article  PubMed  PubMed Central  Google Scholar 

Pastori D, Marang A, Bisson A, Menichelli D, Herbert J, Lip GYH, Fauchier L (2021) Thromboembolism, mortality, and bleeding in 2,435,541 atrial fibrillation patients with and without cancer: A nationwide cohort study. Cancer 127:2122–2129

Article  PubMed  Google Scholar 

Guha A, Jain A, Aggarwal A, Dey AK, Dani S, Ganatra S, Marchlinski FE, Addison D, Fradley MG (2022) Length of stay and cost of care associated with admissions for atrial fibrillation among patients with cancer. BMC Cardiovasc Disord 22:272

Article  PubMed  PubMed Central  Google Scholar 

Vinter N, Christesen AMS, Fenger-Grøn M, Tjønneland A, Frost L (2018) Atrial fibrillation and risk of cancer: A Danish Population‐Based cohort study. JAHA 7:e009543

Article  PubMed  PubMed Central  Google Scholar 

Guha A, Dey AK, Jneid H, Ibarz JP, Addison D, Fradley M (2019) Atrial fibrillation in the era of emerging Cancer therapies. Eur Heart J 40:3007–3010

Article  PubMed  PubMed Central  Google Scholar 

Hajjar LA, Fonseca SMR, Machado TIV (2021) Atrial fibrillation and Cancer. Front Cardiovasc Med 8:590768

Article  CAS  PubMed  PubMed Central  Google Scholar 

Navi BB, Kasner SE, Elkind MSV, Cushman M, Bang OY, DeAngelis LM (2021) Cancer and embolic stroke of undetermined source. Stroke 52:1121–1130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lip GYH, Chin BSP, Blann AD (2002) Cancer and the prothrombotic state. Lancet Oncol 3:27–34

Article  CAS  PubMed  Google Scholar 

Ajabnoor AM, Parisi R, Zghebi SS, Ashcroft DM, Faivre-Finn C, Morris C, Mamas MA, Kontopantelis E (2023) Common Cancer types and risk of stroke and bleeding in patients with nonvalvular atrial fibrillation: A Population‐Based study in England. JAHA 12:e029423

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bungo B, Chaudhury P, Arustamyan M, Rikhi R, Hussain M, Collier P, Kanj M, Khorana AA, Mentias A, Moudgil R (2022) Better prediction of stroke in atrial fibrillation with incorporation of cancer in CHA2DS2VASC score: CCHA2DS2VASC score. IJC Heart Vasculature 41:101072

Article  PubMed  PubMed Central  Google Scholar 

Chan Y-H, Chao T-F, Lee H-F et al (2021) Clinical outcomes in atrial fibrillation patients with a history of Cancer treated with Non-Vitamin K antagonist oral anticoagulants: A nationwide cohort study. Stroke 52:3132–3141

Article  CAS  PubMed  Google Scholar 

Yuan M, Zhang Z, Tse G et al (2019) Association of Cancer and the risk of developing atrial fibrillation: A systematic review and Meta-Analysis. Cardiol Res Pract 2019:1–9

Article  Google Scholar 

Barber M, Nguyen LS, Wassermann J, Spano J-P, Funck-Brentano C, Salem J-E (2019) Cardiac arrhythmia considerations of hormone cancer therapies. Cardiovascular Res 115:878–894

Article  CAS  Google Scholar 

Wiczer TE, Levine LB, Brumbaugh J et al (2017) Cumulative incidence, risk factors, and management of atrial fibrillation in patients receiving ibrutinib. Blood Adv 1:1739–1748

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexandre J, Moslehi JJ, Bersell KR, Funck-Brentano C, Roden DM, Salem J-E (2018) Anticancer drug-induced cardiac rhythm disorders: current knowledge and basic underlying mechanisms. Pharmacol Ther 189:89–103

Article  CAS  PubMed  Google Scholar 

Guha A, Fradley MG, Dent SF, Weintraub NL, Lustberg MB, Alonso A, Addison D (2022) Incidence, risk factors, and mortality of atrial fibrillation in breast cancer: a SEER-Medicare analysis. Eur Heart J 43:300–312

Article  PubMed  Google Scholar 

Grisold W, Oberndorfer S, Struhal W (2009) Stroke and cancer: a review. Acta Neurol Scand 119:1–16

Article  CAS  PubMed  Google Scholar 

Nagasawa H, Kaneko H, Suzuki Y et al (2024) Association of cancer with the risk of developing hypertension. Eur Heart J - Qual Care Clin Outcomes 10:228–234

Article  PubMed  Google Scholar 

Xiao Y, Wang H, Tang Y, Yan J, Cao L, Chen Z, Shao Z, Mei Z, Jiang Z (2021) Increased risk of diabetes in cancer survivors: a pooled analysis of 13 population-based cohort studies. ESMO Open 6:100218

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paterson DI, Wiebe N, Cheung WY, Mackey JR, Pituskin E, Reiman A, Tonelli M (2022) Incident cardiovascular disease among adults with Cancer. JACC: CardioOncology 4:85–94

PubMed  PubMed Central  Google Scholar 

O’Neal WT, Lakoski SG, Qureshi W, Judd SE, Howard G, Howard VJ, Cushman M, Soliman EZ (2015) Relation between Cancer and atrial fibrillation (from the reasons for geographic and Racial differences in stroke Study). Am J Cardiol 115:1090–1094

Article  PubMed  PubMed Central  Google Scholar 

Guo Y, Lip GYH, Apostolakis S (2012) Inflammation in atrial fibrillation. J Am Coll Cardiol 60:2263–2270

Article  CAS  PubMed  Google Scholar 

Aviles RJ, Martin DO, Apperson-Hansen C et al (2003) Inflammation as a risk factor for atrial fibrillation. Circulation 108:3006–3010

Article  PubMed  Google Scholar 

Chen P-S, Chen LS, Fishbein MC, Lin S-F, Nattel S (2014) Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy. Circul Res 114:1500–1515

Article  CAS  Google Scholar 

Simó M, Navarro X, Yuste VJ, Bruna J (2018) Autonomic nervous system and cancer. Clin Auton Res 28:301–314

Article  PubMed  Google Scholar 

Guzzetti S, Costantino G, Fundarò C (2002) Systemic inflammation, atrial fibrillation, and Cancer. https://doi.org/10.1161/01.CIR.0000028399.42411.13. Circulation

Tamargo J, Caballero R, Delpón E (2015) Cancer chemotherapy and cardiac arrhythmias: A review. Drug Saf 38:129–152

Article  CAS  PubMed  Google Scholar 

Yeh ETH, Bickford CL (2009) Cardiovascular complications of Cancer therapy. J Am Coll Cardiol 53:2231–2247

Article  CAS 

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