Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, Fisher M, Pandian J, Lindsay P (2022) World stroke organization (WSO): global stroke fact sheet 2022. Int J Stroke 17:18–29. https://doi.org/10.1177/17474930211065917
Kehrel BE, Fender AC (2016) Resolving thromboinflammation in the brain after ischemic stroke? Circulation 133:2128–2131. https://doi.org/10.1161/CIRCULATIONAHA.116.022858
De Meyer SF, Langhauser F, Haupeltshofer S, Kleinschnitz C, Casas AI (2022) Thromboinflammation in brain ischemia: recent updates and future perspectives. Stroke 53:1487–1499. https://doi.org/10.1161/STROKEAHA.122.038733
Article CAS PubMed Google Scholar
Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer H-U, Burfeind P, Renné C, Gailani D, Nieswandt B, Renné T (2006) Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med 203:513–518. https://doi.org/10.1084/jem.20052458
Article CAS PubMed PubMed Central Google Scholar
Didiasova M, Wujak L, Schaefer L, Wygrecka M (2018) Factor XII in coagulation, inflammation and beyond. Cell Signal 51:257–265. https://doi.org/10.1016/j.cellsig.2018.08.006
Article CAS PubMed Google Scholar
Renné T, Schmaier AH, Nickel KF, Blombäck M, Maas C (2012) In vivo roles of factor XII. Blood 120:4296–4303. https://doi.org/10.1182/blood-2012-07-292094
Article CAS PubMed PubMed Central Google Scholar
Renné T, Stavrou EX (2019) Roles of factor XII in innate immunity. Front Immunol 10:2011. https://doi.org/10.3389/fimmu.2019.02011
Article CAS PubMed PubMed Central Google Scholar
Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun M, McCarty OJT, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, Gailani D (2014) Factor XII Inhibition reduces thrombus formation in a primate thrombosis model. Blood 123:1739–1746. https://doi.org/10.1182/blood-2013-04-499111
Article CAS PubMed PubMed Central Google Scholar
Liu J, Cooley BC, Akinc A, Butler J, Borodovsky A (2020) Knockdown of liver-derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function. Thromb Res 196:200–205. https://doi.org/10.1016/j.thromres.2020.08.040
Article CAS PubMed Google Scholar
Sparkenbaugh EM, Henderson MW, Miller-Awe M, Abrams C, Ilich A, Trebak F, Ramadas N, Vital S, Bohinc D, Bane KL, Chen C, Patel M, Wallisch M, Renné T, Gruber A, Cooley B, Gailani D, Kasztan M, Vercellotti GM, Belcher JD, Gavins FE, Stavrou EX, Key NS, Pawlinski R (2023) Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease. Blood 141:1871–1883. https://doi.org/10.1182/blood.2022017074
Article CAS PubMed PubMed Central Google Scholar
Keat Wei L, Griffiths L, Wee Kooi C, Irene L Meta-Analysis of Factor, Factor V (2019) VII, Factor XII, and Factor XIII-A Gene Polymorphisms and Ischemic Stroke. Medicina 55:101. https://doi.org/10.3390/medicina55040101
Zamolodchikov D, Bai Y, Tang Y, McWhirter JR, Macdonald LE, Alessandri-Haber N (2019) A short isoform of coagulation factor XII mRNA is expressed by neurons in the human brain. Neuroscience 413:294–307. https://doi.org/10.1016/j.neuroscience.2019.05.040
Article CAS PubMed Google Scholar
Shamanaev A, Litvak M, Gailani D (2022) Recent advances in factor XII structure and function. Curr Opin Hematol 29:233–243. https://doi.org/10.1097/MOH.0000000000000727
Article CAS PubMed PubMed Central Google Scholar
Stavrou E, Fang C, Bane K, Long A, Naudin C, Kucukal E, Gandhi A, Brett-Morris A, Mumaw M, Izadmehr S, Merkulova A, Reynolds C, Alhalabi O, Nayak L, Yu W-M, Qu C-K, Meyerson H, Dubyak G, Gurkan U, Schmaier A (2018) Factor XII and uPAR upregulate neutrophil functions to influence wound healing. J Clin Invest 128(3):944–959. https://doi.org/10.1172/JCI92880
Article PubMed PubMed Central Google Scholar
Müller F, Mutch NJ, Schenk WA, Smith SA, Esterl L, Spronk HM, Schmidbauer S, Gahl WA, Morrissey JH, Renné T (2009) Platelet polyphosphates are Proinflammatory and procoagulant mediators in vivo. Cell 139:1143–1156. https://doi.org/10.1016/j.cell.2009.11.001
Article CAS PubMed PubMed Central Google Scholar
Ivanov I, Matafonov A, Sun M-F, Cheng Q, Dickeson SK, Verhamme IM, Emsley J, Gailani D (2017) Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation. Blood 129:1527–1537. https://doi.org/10.1182/blood-2016-10-744110
Article CAS PubMed PubMed Central Google Scholar
Maas C, Renné T (2018) Coagulation factor XII in thrombosis and inflammation. Blood 131:1903–1909. https://doi.org/10.1182/blood-2017-04-569111
Article CAS PubMed Google Scholar
Shamanaev A, Litvak M, Gailani D (2022) Recent advances in factor XII structure and function. Curr Opin Hematol 29(5):233–243. https://doi.org/10.1097/MOH.0000000000000727
Article CAS PubMed PubMed Central Google Scholar
Shamanaev A, Litvak M, Ivanov I, Srivastava P, Sun MF, Dickeson SK, Kumar S, He TZ, Gailani D (2024) Factor XII Structure-Function relationships. Semin Thromb Hemost 50(7):937–952. https://doi.org/10.1055/s-0043-1769509
Article CAS PubMed Google Scholar
Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jämsä A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer J-R, Rose-John S, Butler LM, Salomon O, Stavrou EX, Renné T (2021) Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. Nat Commun 12:5596. https://doi.org/10.1038/s41467-021-25888-7
Article CAS PubMed PubMed Central Google Scholar
Shamanaev A, Ivanov I, Sun M-F, Litvak M, Srivastava P, Mohammed BM, Shaban R, Maddur A, Verhamme IM, McCarty OJT, Law RHP, Gailani D (2022) Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains. Blood Adv 6:3142–3154. https://doi.org/10.1182/bloodadvances.2021005976
Article CAS PubMed PubMed Central Google Scholar
Frunt R, El Otmani H, Smits S, Clark CC, Maas C (2024) Factor XII contact activation can be prevented by targeting 2 unique patches in its epidermal growth factor-like 1 domain with a nanobody. J Thromb Haemost 22:2562–2575. https://doi.org/10.1016/j.jtha.2024.06.005
Article CAS PubMed Google Scholar
Clark CC, Hofman ZLM, Sanrattana W, de Maat S, Maas C (2020) The fibronectin type II domain of factor XII ensures Zymogen quiescence. Thromb Haemost 120(3):400–411. https://doi.org/10.1055/s-0039-3402760
Kaira BG, Slater A, McCrae KR, Dreveny I, Sumya U-M, Mutch NJ, Searle M, Emsley J (2020) Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery. Blood 136(14):1685–1697. https://doi.org/10.1182/blood.2020004818
Henderson LM, Figueroa CD, MüIIer-Esterl W, Bhoola KD (1994) Assembly of Contact-Phase factors on the surface of the human neutrophil membrane. Blood 84:474–482. https://doi.org/10.1182/blood.V84.2.474.474
Article CAS PubMed Google Scholar
Konings J, Govers-Riemslag JWP, Philippou H, Mutch NJ, Borissoff JI, Allan P, Mohan S, Tans G, Ten Cate H, Ariëns RAS (2011) Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin. Blood 118:3942–3951. https://doi.org/10.1182/blood-2011-03-339572
Article CAS PubMed Google Scholar
Sato Y, Sugi T, Sakai R (2019) Ant
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