Zhou B, Zhang J, Zhao Y, Li X, Anderson CS, Xie B, et al. Caregiver-delivered stroke rehabilitation in rural China. Stroke. 2019;50:1825–30.
Ke L, Mao W, Shao F, Zhou J, Xu M, Chen T, et al. Association between pretreatment lymphocyte count and efficacy of immune-enhancing therapy in acute necrotising pancreatitis: a post-hoc analysis of the multicentre, randomised, placebo-controlled TRACE trial. eClinicalMedicine. 2023;58:101915.
Article PubMed PubMed Central Google Scholar
Murray CJL, Lopez AD. Measuring the global burden of disease. N Engl J Med. 2013;369:448–57.
Article CAS PubMed Google Scholar
Rojas JI, Zurrú MC, Romano M, Patrucco L, Cristiano E. Acute ischemic stroke and transient ischemic attack in the very old–risk factor profile and stroke subtype between patients older than 80 years and patients aged less than 80 years. Eur J Neurol. 2007;14:895–9.
Article CAS PubMed Google Scholar
Winovich DT, Longstreth WT, Arnold AM, Varadhan R, Zeki Al Hazzouri A, Cushman M, et al. Factors associated with ischemic stroke survival and recovery in older adults. Stroke. 2017;48:1818–26.
Article PubMed PubMed Central Google Scholar
Hutchins LF, Unger JM, Crowley JJ, Coltman CA, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999;341:2061–7.
Article CAS PubMed Google Scholar
Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: a Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019;50:e344-418.
Pilotto A, Brass C, Fassbender K, Merzou F, Morotti A, Kämpfer N, et al. Premorbid frailty predicts short- and long-term outcomes of reperfusion treatment in acute stroke. J Neurol. 2022;269:3338–42.
Zhang Q, Wang A, Xu Q, Xia X, Tian X, Zhang Y, et al. Efficacy and safety of ginkgo diterpene lactone meglumine in acute ischemic stroke: a randomized clinical trial. JAMA Netw Open. 2023;6: e2328828.
Article PubMed PubMed Central Google Scholar
Wang A, Jia B, Zhang X, Huo X, Chen J, Gui L, et al. Efficacy and safety of butylphthalide in patients with acute ischemic stroke: a randomized clinical trial. JAMA Neurol. 2023;80:851.
Article PubMed PubMed Central Google Scholar
Shimada Y, Nagahara A, Hojo M, Asaoka D, Sasaki H, Ueyama H, et al. Upper gastrointestinal mucosal injury and symptoms in elderly low-dose aspirin users. Gastroenterol Res Pract. 2015;2015: 252963.
Article PubMed PubMed Central Google Scholar
Wang QH, Kuang N, Hu WY, Yin D, Wei YY, Hu TJ. The effect of Panax notoginseng saponins on oxidative stress induced by PCV2 infection in immune cells: in vitro and in vivo studies. J Vet Sci. 2020;21: e61.
Article PubMed PubMed Central Google Scholar
Yang X, Xiong X, Wang H, Wang J. Protective effects of panax notoginseng saponins on cardiovascular diseases: a comprehensive overview of experimental studies. Evid Based Complement Alternat Med. 2014;2014: 204840.
Article PubMed PubMed Central Google Scholar
Zhu B, Zhang W, Lu Y, Hu S, Gao R, Sun Z, et al. Network pharmacology-based identification of protective mechanism of Panax Notoginseng Saponins on aspirin induced gastrointestinal injury. Biomed Pharmacother. 2018;105:159–66.
Article CAS PubMed Google Scholar
Zhou D, Cen K, Liu W, Liu F, Liu R, Sun Y, et al. Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo. J Ethnopharmacol. 2021;272: 113943.
Article CAS PubMed Google Scholar
Li F, Zhao H, Han Z, Wang R, Tao Z, Fan Z, et al. Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway. CNS Neurol Disord Drug Targets. 2019;18:115–23.
Article CAS PubMed Google Scholar
Cai B-X, Li X-Y, Chen J-H, Tang Y-B, Wang G-L, Zhou J-G, et al. Ginsenoside-Rd, a new voltage-independent Ca2+ entry blocker, reverses basilar hypertrophic remodeling in stroke-prone renovascular hypertensive rats. Eur J Pharmacol. 2009;606:142–9.
Article CAS PubMed Google Scholar
Hui Z, Sha D-J, Wang S-L, Li C-S, Qian J, Wang J-Q, et al. Panaxatriol saponins promotes angiogenesis and enhances cerebral perfusion after ischemic stroke in rats. BMC Complement Altern Med. 2017;17:70.
Article PubMed PubMed Central Google Scholar
Zhu T, Meng X-B, Dong D-X, Zhao L-Y, Qu M-W, Sun G-B, et al. Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway. Ann Palliat Med. 2021;10:1650–67.
Zhang J-S, Zhang B-X, Du M-M, Wang X-Y, Li W. Chinese preparation Xuesaitong promotes the mobilization of bone marrow mesenchymal stem cells in rats with cerebral infarction. Neural Regen Res. 2016;11:292–7.
Article CAS PubMed PubMed Central Google Scholar
Wu L, Song H, Zhang C, Wang A, Zhang B, Xiong C, et al. Efficacy and safety of Panax notoginseng saponins in the treatment of adults with ischemic stroke in china: a randomized clinical trial. JAMA Netw Open. 2023;6: e2317574.
Article PubMed PubMed Central Google Scholar
Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP, et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163:2345–53.
Gimbel M, Qaderdan K, Willemsen L, Hermanides R, Bergmeijer T, de Vrey E, et al. Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial. Lancet. 2020;395:1374–81.
Article CAS PubMed Google Scholar
Pan Y, Wu T-T, Hou X-G, Yang Y, Deng C-J, Wang S, et al. Age and outcomes following personalized antiplatelet therapy in chronic coronary syndrome patients: a post hoc analysis of the randomized PATH-PCI trial. Platelets. 2023;34:2206915.
Lindley RI. Drug trials for older people. J Gerontol A Biol Sci Med Sci. 2012;67:152–7.
Gnjidic D, Hilmer SN, Blyth FM, Naganathan V, Waite L, Seibel MJ, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65:989–95.
CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group. Lancet. 1997;349:1641–9.
The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet. 1997;349:1569–81.
Ringleb PA, Bhatt DL, Hirsch AT, Topol EJ, Hacke W, Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events Investigators. Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events. Stroke. 2004;35:528–32.
Article CAS PubMed Google Scholar
Bhatt DL, Marso SP, Hirsch AT, Ringleb PA, Hacke W, Topol EJ. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus. Am J Cardiol. 2002;90:625–8.
Bhatt DL, Chew DP, Hirsch AT, Ringleb PA, Hacke W, Topol EJ. Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery. Circulation. 2001;103:363–8.
Article CAS PubMed Google Scholar
Bonello L, Tantry US, Marcucci R, Blindt R, Angiolillo DJ, Becker R, et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol. 2010;56:919–33.
Comments (0)