Yiqihuoxue decoction (GSC) inhibits mitochondrial fission through the AMPK pathway to ameliorate EPCs senescence and optimize vascular aging transplantation regimens

WHO. Cardiovascular diseases (CVDs). https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1

North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res. 2012;110(8):1097–108.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Camici GG, Savarese G, Akhmedov A, Lüscher TF. Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease. Eur Heart J. 2015;36(48):3392–403.

Article  PubMed  CAS  Google Scholar 

Bianconi V, Sahebkar A, Kovanen P, Bagaglia F, Ricciuti B, Calabrò P, Patti G, Pirro M. Endothelial and cardiac progenitor cells for cardiovascular repair: a controversial paradigm in cell therapy. Pharmacol Ther. 2018;181:156–68.

Article  PubMed  CAS  Google Scholar 

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–217.

Article  PubMed  PubMed Central  Google Scholar 

Sun J, Liu X, Shen C, Zhang W, Niu Y. Adiponectin receptor agonist AdipoRon blocks skin inflamm-ageing by regulating mitochondrial dynamics. Cell Prolif. 2021;54(12): e13155.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Deng X, Liu J, Liu L, Sun X, Huang J, Dong J. Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway. Int J Biol Sci. 2020;16(8):1403–16.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ruiz R, Pérez-Villegas EM, Manuel CÁ. AMPK function in aging process. Curr Drug Targets. 2016;17(8):932–41.

Article  PubMed  CAS  Google Scholar 

Lei Y, Liu JX, Zhou YW. Effect of yuxintong capsule on plasma endothelin and serum nitric oxide in acute myocardial ischemia dogs. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16(5):289–91.

PubMed  CAS  Google Scholar 

Lei Y, Shi DZ, Zhong P. Effect of yuxintong on ECE, NOS gene expression and immunohistochemical studies on cooper-zinc-SOD in ischemic myocardium in experimental dogs. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997;17(10):607–10.

PubMed  CAS  Google Scholar 

Qin F, Huang X. Guanxin II (II) for the management of coronary heart disease. Chin J Integr Med. 2009;15(6):472–6.

Article  PubMed  Google Scholar 

Fan W, Huang Y, Zheng H, Li S, Li Z, Yuan L, Cheng X, He C, Sun J. Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: pharmacology and mechanisms. Biomed Pharmacother. 2020;132:110915.

Article  PubMed  CAS  Google Scholar 

Li D, Rui YX, Guo SD, Luan F, Liu R, Zeng N. Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives. Life Sci. 2021;284: 119921.

Article  PubMed  CAS  Google Scholar 

Lai X, Xiu C, Wang X, Fang J, Yang J, Lei Y. Efficacy of Renshen Sanqi Chuanxiong formula for preventing vascular aging. J Tradit Chin Med. 2019;39(6):780–93.

PubMed  Google Scholar 

Wang X, Zhang JQ, Xiu CK, Yang J, Fang JY, Lei Y. Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway. Oxid Med Cell Longev. 2020;2020:7151946.

Article  PubMed  PubMed Central  Google Scholar 

Wang M, Lei Y. Time-effect relationship of extracts from ginseng, notoginseng and chuanxiong on vascular endothelial cells senescence. Chin J Integr Med. 2014;20(10):758–63.

Article  PubMed  Google Scholar 

Liu Y, Liu Y, Wang X, Xiu C, Hu Y, Wang J, Lei Y, Yang J. Ginseng-Sanqi-Chuanxiong (GSC) extracts attenuate d-galactose-induced vascular aging in mice via inhibition of endothelial progenitor cells senescence. Heliyon. 2024;10(4): e25253.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang D, Chen Y, Xu X, Xiang H, Shi Y, Gao Y, Wang X, Jiang X, Li N, Pan J. Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling. Clin Exp Pharmacol Physiol. 2020;47(3):466–77.

Article  PubMed  CAS  Google Scholar 

Yu Y, Bai F, Liu Y, Yang Y, Yuan Q, Zou D, Qu S, Tian G, Song L, Zhang T, Li S, Liu Y, Wang W, et al. Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways. Mol Cell Biochem. 2015;403(1–2):287–99.

Article  PubMed  CAS  Google Scholar 

Miao J, Liu J, Niu J, Zhang Y, Shen W, Luo C, Liu Y, Li C, Li H, Yang P, Liu Y, Hou FF, Zhou L. Wnt/β-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Aging Cell. 2019;18(5): e13004.

Article  PubMed  PubMed Central  Google Scholar 

Huang J, Hou B, Zhang S, Wang M, Lu X, Wang Q, Liu Y. The Protective Effect of Adiponectin-Transfected Endothelial Progenitor Cells on Cognitive Function in D-Galactose-Induced Aging Rats. Neural Plast. 2020;2020:1273198.

Article  PubMed  PubMed Central  Google Scholar 

Wen M. Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model. Evid Based Complement Alternat Med. 2015;2015: 972749.

Article  PubMed  PubMed Central  Google Scholar 

Wang R, Liu L, Liu H, Wu K, Liu Y, Bai L, Wang Q, Qi B, Qi B, Zhang L. Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging. Aging. 2019;11(17):7021–35.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qiao J, Ding L, Fu J, Yao H, Li X, Chen C, Yang N, Mi H, Liu Y, Chu P, Xia Y, Zhang X, Xu K, et al. Endothelial progenitor cells improve the quality of transplanted hematopoietic stem cells and maintain longer term effects in mice. Ann Hematol. 2017;96(1):107–14.

Article  PubMed  Google Scholar 

Liu H, Liu J, Liu C, Niu X, Liu J. Transplantation of endothelial progenitor cells improves myocardial hypertrophy in spontaneously hypertensive rats through HO-1/CREB3/AKT axis. Arch Biochem Biophys. 2023;746: 109739.

Article  PubMed  CAS  Google Scholar 

Chen WR, Zhou YJ, Sha Y, Wu XP, Yang JQ, Liu F. Melatonin attenuates vascular calcification by inhibiting mitochondria fission via an AMPK/Drp1 signalling pathway. J Cell Mol Med. 2020;24(11):6043–54.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang Z, Ding Z, Xu Y, Xi C, He L, Luo H, Guo Q, Huang C. Downregulation of nuclear STAT2 protein in the spinal dorsal horn is involved in neuropathic pain following chronic constriction injury of the rat sciatic nerve. Front Pharmacol. 2023;14:1069331.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wu M, Wu X, Cheng Y, Shen Z, Chen X, Xie Q, Chu J, Li J, Liu L, Wei L, Long L, Cai Q, Peng J, et al. Qingda Granule Attenuates Angiotensin II-Induced Blood Pressure and Inhibits Ca(2+)/ERK Signaling Pathway. Front Pharmacol. 2021;12: 688877.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ren R, Guo J, Shi J, Tian Y, Li M, Kang H. PKM2 regulates angiogenesis of VR-EPCs through modulating glycolysis, mitochondrial fission, and fusion. J Cell Physiol. 2020;235(9):6204–17.

Article  PubMed  CAS  Google Scholar 

Kim DY, Jung SY, Kim YJ, Kang S, Park JH, Ji ST, Jang WB, Lamichane S, Lamichane BD, Chae YC, Lee D, Chung JS, Kwon SM. Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation. Kor J Physiol Pharmacol. 2018;22(2):203–13.

Article  CAS  Google Scholar 

Tu Q, Wang JF, Xie HQ, Zhao Q, Fu J, Xu HL, Cao Z. Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression. Mol Cell Endocrinol. 2021;538: 111455.

Comments (0)

No login
gif