The Role of Time as a Prognostic Factor in Pediatric Brain Tumors: a Multivariate Survival Analysis

Wells EM, Packer RJ (2015) Pediatric brain tumors. Continuum 21:373–396

PubMed  Google Scholar 

Siegel RL, Miller KD, Jemal A (2019) Cancer statistics, 2019. CA Cancer J Clin 69:7–34

PubMed  Google Scholar 

Siegel RL, Miller KD, Jemal A (2016) Cancer statistics. CA Cancer J Clin 66:7–30

PubMed  Google Scholar 

Wilne S, Collier J, Kennedy C, Koller K, Grundy R, Walker D (2007) Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncol 8:685–695

PubMed  Google Scholar 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424

PubMed  Google Scholar 

Dang-Tan T, Franco EL (2007) Diagnosis delays in childhood cancer. Cancer. 110:703–713

PubMed  Google Scholar 

Crawford JR, Santi MR, Vezina G, Myseros JS, Keating RF, LaFond DA et al (2007) CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis. Neurology. 68:1668–1673

CAS  PubMed  Google Scholar 

Patel V, McNinch NL, Rush S (2019) Diagnostic delay and morbidity of central nervous system tumors in children and young adults: a pediatric hospital experience. J Neuro-Oncol 143:297–304

Google Scholar 

Shay V, Fattal-Valevski A, Beni-Adani L, Constantini S (2012) Diagnostic delay of pediatric brain tumors in Israel: a retrospective risk factor analysis. Childs Nerv Syst 28:93–100

PubMed  Google Scholar 

Sethi RV, Marino R, Niemierko A, Tarbell NJ, Yock TI, MacDonald SM (2013) Delayed diagnosis in children with intracranial germ cell tumors. J Pediatr 163:1448–1453

PubMed  Google Scholar 

Kukal K, Dobrovoljac M, Boltshauser E, Ammann RA, Grotzer MA (2009) Does diagnostic delay result in decreased survival in paediatric brain tumours? Eur J Pediatr 168:303–310

PubMed  Google Scholar 

Flores LE, Williams DL, Bell BA, O’Brien M, Ragab AH (1986) Delay in the diagnosis of pediatric brain tumors. Am J Dis Child 140:684–686

CAS  PubMed  Google Scholar 

Handayani K, Sitaresmi MN, Supriyadi E, Widjajanto PH, Susilawati D, Njuguna F, van de Ven PM, Kaspers GJL, Mostert S (2016) Delays in diagnosis and treatment of childhood cancer in Indonesia. Pediatr Blood Cancer 63:2189–2196

CAS  PubMed  Google Scholar 

Dobrovoljac M, Hengartner H, Boltshauser E, Grotzer M (2002) Delay in the diagnosis of paediatric brain tumours. Eur J Pediatr 161:663–667

PubMed  Google Scholar 

Molineus A, Boxberger N, Redlich A, Vorwerk P (2013) Time to diagnosis of brain tumors in children: a single-Centre experience. Pediatr Int 55:305–309

PubMed  Google Scholar 

Azizi AA, Heßler K, Leiss U, Grylli C, Chocholous M, Peyrl A, Gojo J, Slavc I (2017) From symptom to diagnosis—the Prediagnostic symptomatic interval of pediatric central nervous system tumors in Austria. Pediatr Neurol 76:27–36

PubMed  Google Scholar 

Mehta V, Chapman A, McNeely PD, Walling S, Howes WJ (2002) Latency between symptom onset and diagnosis of pediatric brain tumors: an eastern Canadian geographic study. Neurosurgery. 51:365–373

PubMed  Google Scholar 

Stocco C, Pilotto C, Passone E, Nocerino A, Tosolini R, Pusiol A, Cogo P (2017) Presentation and symptom interval in children with central nervous system tumors. A single-center experience. Childs Nerv Syst 33:2109–2116

PubMed  Google Scholar 

Wilne S, Collier J, Kennedy C, Jenkins A, Grout J, Mackie S, Koller K, Grundy R, Walker D (2012) Progression from first symptom to diagnosis in childhood brain tumours. Eur J Pediatr 171:87–93

PubMed  Google Scholar 

Reulecke BC, Erker CG, Fiedler BJ, Niederstadt T-U, Kurlemann G (2008) Brain tumors in children: initial symptoms and their influence on the time span between symptom onset and diagnosis. J Child Neurol 23:178–183

PubMed  Google Scholar 

Elhassan MMA, Mohamedani AA, Osman HHM, Yousif NO, Elhaj NM, Qaddoumi I (2019) Patterns, treatments, and outcomes of pediatric central nervous system tumors in Sudan: a single institution experience. Childs Nerv Syst 35:437–444

PubMed  Google Scholar 

Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi J-I, Mishima K, Fujimaki T, Matsutani M, Nishikawa R (2014) Duration between onset and diagnosis in central nervous system tumors: impact on prognosis and functional outcome. Pediatr Int 56:829–833

PubMed  Google Scholar 

Walker D, Wilne S, Grundy R, Kennedy C, Neil DA et al (2016) A new clinical guideline from the Royal College of Paediatrics and Child Health with a national awareness campaign accelerates brain tumor diagnosis in UK children - “headSmart: Be Brain Tumour Aware”. Neuro-Oncology 18:445–454

Google Scholar 

Abdelmabood S, Kandil S, Megahed A, Fouda A (2017) Delays in diagnosis and treatment among children with cancer: Egyptian perspective. East Mediterr Health J 23:422–429

PubMed  Google Scholar 

Njuguna F, Martijn H, Langat S, Musimbi J, Muliro H, Skiles J, Vik T, Sitaresmi MN, van de Ven PM, Kaspers GJL, Mostert S (2016) Factors influencing time to diagnosis and treatment among pediatric oncology patients in Kenya. Pediatr Hematol Oncol 33:186–199

CAS  PubMed  Google Scholar 

INEGI. Encuesta Intercensal 2015. In: Instituto Nacional de Estadística y Geografía [Internet]. 14 Mar 2015 [cited 28 Jan 2020]. Available: https://www.inegi.org.mx/programas/intercensal/2015/

CONAPO. 31.4 por ciento de la población en México son niñas, niños y adolescentes, de 0 a 17 años. In: Consejo Nacional de Población [Internet]. 30 April, 2019 [cited 28 Jan 2020]. Available: https://www.gob.mx/conapo/prensa/31-4-por-ciento-de-la-poblacion-en-mexico-son-ninas-ninos-y-adolescentes-de-0-a-17-anos-198293?idiom=es

INEGI. Por actividad económica. In: Instituto Nacional de Estadística y Geografía [Internet]. 2018 [cited 28 Jan 2020]. Available: https://www.inegi.org.mx/temas/pib/

CONEVAL. Medición de Pobreza 2008-2018, Estados Unidos Mexicanos. In: Consejo Nacional de Evaluación de la Política de Desarrollo Social [Internet]. 2018 [cited 28 Jan 2020]. Available: https://www.coneval.org.mx/Medicion/PublishingImages/Pobreza_2018/Serie_2008-2018.jpg

Santos-Preciado JI (2008) El Hospital Infantil de México y su Boletín Médico: un hito en la historia de la pediatría mexicana. Bol Med Hosp Infant Mex 65:81–82

Google Scholar 

de León Castro-Sierra Eduardo FC-P, Perez Peña-Diazconti M et al (2006) Bol Med Hosp Infant Mex 63:367–381

Google Scholar 

Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C, Barnholtz-Sloan JS (2018) CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015. Neuro Oncol 20:iv1–iv86

PubMed  PubMed Central  Google Scholar 

Rivas-Vilela S, Rubió-Casadevall J, Fàbrega-Ribas A, Joly-Torta C, Vilardell L, Marcos-Gragera R (2019) Incidence and survival of central nervous system tumors in childhood and adolescence in Girona (Spain) 1990–2013: national and international comparisons. Clin Transl Oncol 21:1177–1185. https://doi.org/10.1007/s12094-019-02043-9

Article  CAS  PubMed  Google Scholar 

Desandes E, Guissou S, Chastagner P, Lacour B (2014) Incidence and survival of children with central nervous system primitive tumors in the French National Registry of childhood solid tumors. Neuro-Oncology 16:975–983

PubMed  PubMed Central  Google Scholar 

Farinotti M, Ferrarini M, Solari A, Filippini G (1998) Incidence and survival of childhood CNS tumours in the region of Lombardy. Italy Brain 121(Pt 8):1429–1436

PubMed  Google Scholar 

Magnani C, Aareleid T, Viscomi S, Pastore G, Berrino F, Oberaigner W et al (2001) Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. Eur J Cancer 37:711–721

CAS  PubMed  Google Scholar 

Robertson PL, Zeltzer PM, Boyett JM, Rorke LB, Allen JC, Geyer JR, Stanley P, Li H, Albright AL, McGuire-Cullen P, Finlay JL, Stevens KR, Milstein JM, Packer RJ, Wisoff J, _ _ Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children’s Cancer group. J Neurosurg 1998;88: 695–703

CAS  PubMed  Google Scholar 

de Araujo OL, da Trindade KM, Trompieri NM, Fontenele JB, Felix FHC (2011) Analysis of survival and prognostic factors of pediatric patients with brain tumor. J Pediatr 87:425–432

Google Scholar 

María GVM, Francis ERN, Nelson UL, Gutiérrez E, Gimón AV, Barboza D et al (2013) Tumores cerebrales pediátricos experiencia de 10 años. Revista Venezolana de Oncologia 25:85–97

Google Scholar 

Zareifar S, Rowshani F, Haghpanah S, Bordbar M (2018) Five- year survival rate of children with central nervous system tumors in shiraz, Iran. Iranian Journal of Pediatric Hematology and Oncology 8:1–11

Google Scholar 

Mehrvar A, Faranoush M, Hedayati Asl AA, Tashvighi M, Fazeli MA, Qaddoumi I, Mehrvar N, Sobuti B, Jafarpour A, Ravan parsa R, Zangooei R, Alebouyeh M, Vossough P (2014) Childhood central nervous system tumors at MAHAK’s pediatric Cancer treatment and research center (MPCTRC), Tehran. Iran Childs Nerv Syst 30:491–496

PubMed  Google Scholar 

KA R (2011, 810) Epidemiology and survival of childhood primary central nervous system malignancies in Iran: Results from a single center. Pediatr Blood Cancer 57

Grob ST, Levy JMM (2017) Improving diagnostic and therapeutic outcomes in pediatric brain tumors. Mol Diagn Ther 22:25–39. https://doi.org/10.1007/s40291-017-0299-3

Article  Google Scholar 

Pogorzala M, Styczynski J, Wysocki M (2014) Survival and prognostic factors in children with brain tumors: long-term follow-up single center study in Poland. Anticancer Res 34:323–326

PubMed  Google Scholar 

Segal D, Karajannis MA (2016) Pediatric brain tumors: an update. Curr Probl Pediatr Adolesc Health Care 46:242–250

PubMed  Google Scholar 

Rey-Casserly C, Diver T (2019) Late effects of pediatric brain tumors. Curr Opin Pediatr 31:789–796

PubMed  Google Scholar 

Chen J, Mullen CA (2017) Patterns of diagnosis and misdiagnosis in pediatric Cancer and relationship to survival. J Pediatr Hematol Oncol 39:e110–e115

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