Selenium deficiency exacerbates cartilage degradation caused by HT-2 toxin via notch signaling pathway activation

Xiong G (2001) Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province. PR China Int Orthop 25(3):147–150. https://doi.org/10.1007/s002640100248

Article  CAS  PubMed  Google Scholar 

Roman M, Jitaru P, Barbante C (2014) Selenium biochemistry and its role for human health. Metallomics 6(1):25–54. https://doi.org/10.1039/c3mt00185g

Article  CAS  PubMed  Google Scholar 

Mehdi Y, Hornick JL, Istasse L, Dufrasne I (2013) Selenium in the environment, metabolism and involvement in body functions. Molecules 18(3):3292–3311. https://doi.org/10.3390/molecules18033292

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang D, Lee J, Wu C, Guo X, Lee BJ, Chun JS, Kim JH (2020) The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies. Exp Mol Med 52(8):1198–1208. https://doi.org/10.1038/s12276-020-0408-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avery JC, Hoffmann PR (2018) Selenium, selenoproteins, and immunity. Nutrients. https://doi.org/10.3390/nu10091203

Article  PubMed  PubMed Central  Google Scholar 

Haubruge E, Chasseur C, Debouck C, Begaux F, Suetens C, Mathieu F, Michel V, Gaspar C, Rooze M, Hinsenkamp M, Gillet P, Nolard N, Lognay G (2001) The prevalence of mycotoxins in Kashin-Beck disease. Int Orthop 25(3):159–161. https://doi.org/10.1007/s002640100240

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desjardins AE, Hohn TM, McCormick SP (1993) Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol Rev 57(3):595–604. https://doi.org/10.1128/mr.57.3.595-604.1993

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang J (1995) Research report on the etiology of Kashin-Beck disease(KBD). Chinese J Endemiol 14:201–204

Google Scholar 

Yu FF, Lin XL, Yang L, Liu H, Wang X, Fang H, Lammi ZJ, Guo X (2017) Comparison of T-2 toxin and HT-2 toxin distributed in the skeletal system with that in other tissues of rats by acute toxicity test. Biomed Environ Sci 30(11):851–854. https://doi.org/10.3967/bes2017.115

Article  CAS  PubMed  Google Scholar 

Yu FF, Lin XL, Wang X, Liu H, Yang L, Goldring MB, Lammi MJ, Guo X (2017) Selenium promotes metabolic conversion of T-2 toxin to HT-2 toxin in cultured human chondrocytes. J Trace Elem Med Biol 44:218–224. https://doi.org/10.1016/j.jtemb.2017.08.009

Article  CAS  PubMed  Google Scholar 

Li D, Han J, Guo X, Qu C, Yu F, Wu X (2016) The effects of T-2 toxin on the prevalence and development of Kashin-Beck disease in China: a meta-analysis and systematic review. Toxicol Res (Camb) 5(3):731–751. https://doi.org/10.1039/c5tx00377f

Article  CAS  PubMed  Google Scholar 

Yu FF, Lin XL, Wang X, Ping ZG, Guo X (2019) Comparison of apoptosis and autophagy in human chondrocytes induced by the T-2 and HT-2 Toxins. Toxins (Basel). https://doi.org/10.3390/toxins11050260

Article  PubMed  Google Scholar 

Jia Y, Shi S, Cheng B, Cheng S, Liu L, Meng P, Yang X, Chu X, Wen Y, Zhang F, Guo X (2022) Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity. Front Nutr 9:935112. https://doi.org/10.3389/fnut.2022.935112

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang F, Lammi MJ, Shao W, Zhang P, Zhang Y, Wei H, Guo X (2019) Cytotoxic properties of HT-2 toxin in human chondrocytes: could T(3) inhibit toxicity of HT-2? Toxins (Basel). https://doi.org/10.3390/toxins11110667

Article  PubMed  PubMed Central  Google Scholar 

Ning Y, Zhang P, Zhang F, Chen S, Liu Y, Chen F, Wu Y, Li S, Wang C, Gong Y, Hu M, Huang R, Zhao H, Guo X, Wang X, Yang L (2022) Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis. Front Genet 13:1064565. https://doi.org/10.3389/fgene.2022.1064565

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Liu H, Lin X, Zhang F, Meng P, Tan S, Lammi MJ, Guo X (2021) Dysregulation of cells cycle and apoptosis in human induced pluripotent stem cells chondrocytes through p53 pathway by HT-2 toxin: an in vitro study. Front Genet 12:677723. https://doi.org/10.3389/fgene.2021.677723

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Liu X, Liu J, Wang G, Wan K (2012) Contamination level of T-2 and HT-2 toxin in cereal crops from Aba area in Sichuan Province. China Bull Environ Contam Toxicol 88(3):396–400. https://doi.org/10.1007/s00128-011-0478-6

Article  CAS  PubMed  Google Scholar 

Zhang B, Yang L, Wang W, Li Y, Li H (2011) Environmental selenium in the Kaschin-Beck disease area, Tibetan Plateau. China Environ Geochem Health 33(5):495–501. https://doi.org/10.1007/s10653-010-9366-y

Article  CAS  PubMed  Google Scholar 

Yu FF, Zuo J, Sun L, Yu SY, Lei XL, Zhu JH, Zhou GY, Guo X, Ba Y (2022) Animal models of Kashin-Beck disease exposed to environmental risk factors: methods and comparisons. Ecotoxicol Environ Saf 234:113419. https://doi.org/10.1016/j.ecoenv.2022.113419

Article  CAS  PubMed  Google Scholar 

Sassi N, Laadhar L, Driss M, Kallel-Sellami M, Sellami S, Makni S (2011) The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies. Arthritis Res Ther 13(2):208. https://doi.org/10.1186/ar3255

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prein C, Beier F (2019) ECM signaling in cartilage development and endochondral ossification. Curr Top Dev Biol 133:25–47. https://doi.org/10.1016/bs.ctdb.2018.11.003

Article  CAS  PubMed  Google Scholar 

Li S, Cao J, Caterson B, Hughes CE (2012) Proteoglycan metabolism, cell death and Kashin-Beck disease. Glycoconj J 29(5–6):241–248. https://doi.org/10.1007/s10719-012-9421-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li SH, Wu QF (2021) MicroRNAs target on cartilage extracellular matrix degradation of knee osteoarthritis. Eur Rev Med Pharmacol Sci 25(3):1185–1197. https://doi.org/10.26355/eurrev_202102_24821

Article  PubMed  Google Scholar 

Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H (2013) Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development. Proc Natl Acad Sci U S A 110(5):1875–1880. https://doi.org/10.1073/pnas.1207458110

Article  PubMed  PubMed Central  Google Scholar 

Mahjoub M, Sassi N, Driss M, Laadhar L, Allouche M, Hamdoun M, Romdhane KB, Sellami S, Makni S (2012) Expression patterns of Notch receptors and their ligands in human osteoarthritic and healthy articular cartilage. Tissue Cell 44(3):182–194. https://doi.org/10.1016/j.tice.2012.03.001

Article  CAS  PubMed  Google Scholar 

Zhang D, Zhang D, Yang X, Li Q, Zhang R, Xiong Y (2023) The role of selenium-mediated notch/hes1 signaling pathway in Kashin-Beck disease patients and cartilage injury models. Biol Trace Elem Res 201(6):2765–2774. https://doi.org/10.1007/s12011-022-03387-0

Article  CAS  PubMed  Google Scholar 

Hong Y, Mu X, Ji X, Chen X, Geng Y, Zhang Y, Liu Q, Li F, Wang Y, He J (2021) In-utero exposure to HT-2 toxin affects meiotic progression and early oogenesis in foetal oocytes by increasing oxidative stress. Environ Pollut 279:116917. https://doi.org/10.1016/j.envpol.2021.116917

Article  CAS  PubMed 

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