Optimization of Risperidone and Quercetin Solid Lipid Nanoparticles Loaded Nasal Insitu Gel by Design Expert and Quality by Design Approach

Hauw JJ, Lubetzki C, Tourbah A. Multiple sclerosis: one or several diseases. Rev Prat. 1999;49(17):1848–52.

CAS  PubMed  Google Scholar 

Goldenberg MM. Multiple sclerosis review. P T. 2012;37(3):175–84.

PubMed  PubMed Central  Google Scholar 

Javanbakht P, Yazdi FR, Taghizadeh F, Khadivi F, Hamidabadi HG, Kashani IR, Zarini D, Mojaverrostami S. QUE as a possible complementary therapy in multiple sclerosis: anti-oxidative, anti-inflammatory and remyelination potential properties. Heliyon. 2023; 9(11).

Georgopoulou E, Bornivelli C, Choustoulakis I, Alivanis P. Psychosis in a multiple sclerosis patient and antipsychotic treatment. Ann Gen Psychiatry. 2008;7(1).

La Flamme AC, Abernethy D, Sim D, Goode L, Lockhart M, Bourke D et al. Safety and acceptability of clozapine and RIS in progressive multiple sclerosis: a phase I, randomised, blinded, placebo-controlled trial. BMJ Neurol Open. 2020;2(1).

Riva A, Ronchi M, Petrangolini G, Bosisio S, Allegrini P. Improved oral absorption of QUE from QUE Phytosome®, a New Delivery System based on Food Grade Lecithin. Eur J Drug Metab Pharmacokinet. 2019;44(2):169–77.

Article  CAS  PubMed  Google Scholar 

Solnier J, Zhang Y, Roh K, Kuo YC, Du M, Wood S, Hardy M, Gahler RJ, Chang C. A pharmacokinetic study of different QUE formulations in healthy participants: a Diet-Controlled, crossover, single- and multiple-dose pilot study. Evid Based Complement Alternat Med. 2023;10.

O’Sullivan D, Green L, Stone S, Zareie P, Kharkrang M, Fong D et al. Treatment with the antipsychotic agent, RIS, reduces disease severity in experimental autoimmune encephalomyelitis. PLoS ONE. 2014;9(8):e104430

Kumar M, Kakkar V, Mishra AK, Chuttani K, Kaur IP. Intranasal delivery of streptomycin sulfate (STRS) loaded SLN to brain and blood. Int J Pharm. 2014;461(1–2):223–33.

CAS  PubMed  Google Scholar 

Brioschi AM, Calderoni S, Zara GP, Priano L, Gasco MR, Mauro A. SLN for brain tumors therapy: state of the art and novel challenges. Prog Brain Res. 2009;180:193–223.

Article  CAS  PubMed  Google Scholar 

Patel S, Chavhan S, Soni H, Babbar AK, Mathur R, Mishra AK, et al. Brain targeting of RIS-loaded SLN by intranasal route. J Drug Target. 2011;19(6):468–74.

Article  CAS  PubMed  Google Scholar 

Wechsler J. Washington Report-FDA proposes Flexible Oversight for Quality systems-manufacturers seek real-world benefits from investment in QbD and risk-management strategies. Pharm Technol. 2008;32(10):32.

Google Scholar 

Namjoshi S, Dabbaghi M, Roberts MS, Grice JE, Mohammed Y. QbD: development of the Quality Target Product Profile (QTPP) for Semisolid Topical products. Pharmaceutics. 2020;12(3):287.

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, Mao S. Application of QbD in the current drug development. Asian J Pharm Sci. 2017;12(1):1–8.

PubMed  Google Scholar 

Yu LX, Amidon G, Khan MA, Hoag SW, Polli J, Raju GK, Woodcock J. Understanding pharmaceutical QbD. AAPS J. 2014;16(4):771–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joshi AS, Patel HS, Belgamwar VS, Agrawal A, Tekade AR. SLN of ondansetron HCl for intranasal delivery: development, optimization and evaluation. J Mater Sci Mater Med. 2012;23:2163–75.

Article  CAS  PubMed  Google Scholar 

Das S, Ng WK, Kanaujia P, Kim S, Tan RB. Formulation design, preparation and physicochemical characterizations of SLN containing a hydrophobic drug: effects of process variables. Colloids Surf B Biointerfaces. 2011;88(1):483–9.

Article  CAS  PubMed  Google Scholar 

Musielak E, Feliczak-Guzik A, Nowak I. Optimization of the conditions of SLN synthesis. Molecules. 2022;27(7):2202.

Article  CAS  PubMed  PubMed Central  Google Scholar 

16 Duong VA, Nguyen TT, Maeng HJ. Preparation of SLN and Nanostructured lipid carriers for drug delivery and the effects of Preparation parameters of Solvent Injection Method. Molecules. 2020;25(20):4781.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghasemiyeh P, Mohammadi-Samani S. SLN and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Res Pharm Sci. 2018;13(4):288–303.

Article  PubMed  PubMed Central  Google Scholar 

Mukherjee S, Ray S, Thakur RS. SLN: a modern formulation approach in drug delivery system. Indian J Pharm Sci. 2009;71(4):349–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maddiboyina B, Jhawat V, Nakkala RK, Desu PK, Gandhi S. Design expert assisted formulation, characterization and optimization of microemulsion based SLN of repaglinide. Prog Biomater. 2021;10(4):309–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hao J, Fang X, Zhou Y, Wang J, Guo F, Li F, Peng X. Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design. Int J Nanomed. 2011;6:683–92.

CAS  Google Scholar 

Zingale E, Rizzo S, Bonaccorso A, Consoli V, Vanella L, Musumeci T, Spadaro A, Pignatello R. Optimization of lipid nanoparticles by response surface methodology to improve the ocular delivery of Diosmin: characterization and In-Vitro Anti-inflammatory Assessment. Pharmaceutics. 2022;14(9):1961.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nikam S, Chaudhari S. Optimization of Green Synthesized Black Tea Nanoparticles using Central Composite Design. Int J Pharm Invest. 2022;13(1):28–36.

Article  Google Scholar 

Nikam SA, Chaudhari SP. Biosynthesis of silver nanoparticles from Polyphenolic Extract of Baliospermun solanifolium using Central Composite Design. Pharmacog Res. 2022;14(4):405–11.

Article  CAS  Google Scholar 

Shah B, Khunt D, Bhatt H, Misra M, Padh H. Application of QbD approach for intranasal delivery of rivastigmine loaded SLN: effect on formulation and characterization parameters. Eur J Pharm Sci. 2015;78:54–66.

Article  CAS  PubMed  Google Scholar 

Stella B, Peira E, Dianzani C, Gallarate M, Battaglia L, Gigliotti CL, Boggio E, Dianzani U, Dosio F. Development and characterization of SLN loaded with a highly active Doxorubicin Derivative. Nanomaterials (Basel). 2018;8(2):110.

Article  PubMed  Google Scholar 

Andonova V, Peneva P. Characterization methods for SLN and nanostructured lipid carriers (NLC). Curr Pharm Des. 2017;14.

Ramireddy AR, Behara DK. QbD Based Formulation Development and Optimisation of Ozenoxacin Topical Nano-Emulgel and efficacy evaluation using Impetigo mice Model. AAPS PharmSciTech. 2024;25(5):90.

Article  CAS  PubMed  Google Scholar 

Kumar M, Kumar D, Singh S, Chopra S, Mahmood S, Bhatia A. QbD Perspective for Designing Foam-based Formulation: current state of art. Curr Pharm Des. 2024;30(6):410–9.

Article  CAS  PubMed  Google Scholar 

Jayawardena HSN, Liyanage SH, Rathnayake K, Patel U, Yan M. Analytical methods for characterization of Nanomaterial surfaces. Anal Chem. 2021;93(4):1889–911.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shah BM, Misra M, Shishoo CJ, Padh H. Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization. Drug Deliv. 2015;22(7):918–30.

Article  CAS  PubMed  Google Scholar 

Froelich A, Osmałek T, Jadach B, Puri V, Michniak-Kohn B. Microemulsion-based media in nose-to-brain drug delivery. Pharmaceutics. 2021;13(2):201.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garala K, Joshi P, Shah M, Ramkishan A, Patel J. Formulation and evaluation of periodontal in situ gel. Int J Pharm Investig. 2013;3(1):29–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurniawansyah IS, Rusdiana T, Sopyan I, Ramoko H, Wahab HA, Subarnas A. In situ ophthalmic gel forming systems of poloxamer 407 and hydroxypropyl methyl cellulose mixtures for sustained ocular delivery of chloramphenicole: optimization study by factorial design. Heliyon. 2020;6(11):e05365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ullah KH, Raza F, Munawar SM, Sohail M, Zafar H, Zafar MI, Ur-Rehman T. Poloxamer 407 based gel formulations for Transungual Delivery of Hydrophobic drugs: selection and optimization of potential additives. Polymers. 2021;13(19):3376.

Comments (0)

No login
gif