Allorge-Boiteau L (1996) Madagascar centre de speciation et d’origine du genre Kalanchoe (Crassulaceae). Biogeogr Madagascar 8:137–145

Google Scholar 

Andrade AWL, Guerra GCB, de Souza Araújo DF, de Araújo Júnior RF, de Araújo AA, Carvalho TG, Fernandes JM, Diez-Echave P, Hidalgo-García L, Rodriguez-Cabezas ME, Gálvez J, Zucolotto SM (2020) Anti-inflammatory and chemopreventive effects of Bryophyllum pinnatum (Lamarck) leaf extract in experimental colitis models in rodents. Front Pharmacol 11:998. https://doi.org/10.3389/fphar.2020.00998

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anvisa (2004) Guia de Estabilidade de Produtos Cosméticos, Agência Nacional de Vigilância Sanitária, Brasilia, DF. https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/cosmeticos/manuais-e-guias/guia-de-estabilidade-de-cosmeticos.pdf/, accessed 4/September/2024

Anvisa (2017) RDC No 166 , 24 Julho 2017, Agência Nacional de Vigilância Sanitária. Brasilia DF. https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2017/rdc0166_24_07_2017.pdf, accessed 4/May/2023

Araújo ERD, Xavier-Santos JB, da Silva VC, de Lima JBF, Schlamb J, Fernandes-Pedrosa MF, da Silva Júnior AA, de Araújo Júnior RF, Rathinasabapathy T, Moncada M, Espodito D, Guerra GCB, Zucolotto SM (2023) Gel formulated with Bryophyllum pinnatum leaf extract promotes skin wound healing in vivo by increasing VEGF expression: a novel potential active ingredient for pharmaceuticals. Front Pharmacol 13:1104705. https://doi.org/10.3389/fphar.2022.1104705

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atipairin A, Chunhachaichana C, Nakpheng T, Changsan N, Srichana T, Sawatdee S (2020) Development of a sildenafil citrate microemulsion-loaded hydrogel as a potential system for drug delivery to the penis and its cellular metabolic mechanism. Pharmaceutics 12:1055. https://doi.org/10.3390/pharmaceutics12111055

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barreto SMAG, Maia MS, Benicá AM, de Assis HRBS, Leite-Silva VR, Rocha-Filho PA, de Negreiros MMF, de Oliveira Rocha HA, Ostrosky EA, Lopes PS, de Farias Sales VS, Giordani RB, Ferrari M (2017) Evaluation of in vitro and in vivo safety of the by-product of Agave sisalana as a new cosmetic raw material: development and clinical evaluation of a nanoemulsion to improve skin moisturizing. Ind Crops Prod 108:470–479. https://doi.org/10.1016/j.indcrop.2017.06.064

Article  CAS  Google Scholar 

Czyrski A, Sznura J (2019) The application of Box-Behnken design in the optimization of HPLC separation of fluoroquinolones. Sci Rep 9:19458. https://doi.org/10.1038/s41598-019-55761-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

da Silveira Almeida WAS, Sousa LRD, dos Santos Antunes A, de Azevedo AS, do Nascimento AM, Amparo TR, de Souza GHB, dos Santos ODH, Andrade AL, dos Santos VMR (2020) Green propolis: in vitro photoprotective and photostability studies of single and incorporated extracts in a sunscreen formulation. Rev Bras Farmacogn 30:436-44https://doi.org/10.1007/s43450-020-00071-z

De Araújo ERD, Guerra GCB, Andrade AWL, Fernandes JM, da Silva VC, de Aragão TE, de Araújo AA, de Araújo Júnior RF, Zucolotto SM (2021) Gastric ulcer healing property of Bryophyllum pinnatum leaf extract in chronic model in vivo and gastroprotective activity of its major flavonoid. Front Pharmacol 12:744192. https://doi.org/10.3389/fphar.2021.744192

Article  CAS  PubMed  PubMed Central  Google Scholar 

dos Santos Nascimento LB, de Aguiar PF, Leal-Costa MV, Coutinho MAS, Borsodi MPG, Rossi-Bergmann B, Tavares ES, Costa SS (2018) Optimization of aqueous extraction from Kalanchoe pinnata leaves to obtain the highest content of an anti-inflammatory flavonoid using a response surface model. Phytochem Anal 29:308–315. https://doi.org/10.1002/pca.2744

Article  CAS  PubMed  Google Scholar 

García-Pérez P, Ayuso M, Lozano-Milo E, Pereira C, Dias MI, Ivanov M, Calhelha RC, Soković M, Ferreira ICFR, Barros L, Gallego PP (2021) Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants. Ind Crops Prod 162:113241. https://doi.org/10.1016/j.indcrop.2021.113241

Article  CAS  Google Scholar 

Gehrig H, Gaußmann O, Marx H, Schwarzott D, Kluge M (2001) Molecular phylogeny of the genus Kalanchoe (Crassulaceae) inferred from nucleotide sequences of the ITS-1 and ITS-2 regions. Plant Sci 160:827–835. https://doi.org/10.1016/S0168-9452(00)00447-7

Article  CAS  PubMed  Google Scholar 

Gouveia F, Bicker J, Santos J, Rocha M, Alves G, Falcão A, Fortuna A (2020) Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma. J Pharm Biomed Anal 181:113109. https://doi.org/10.1016/j.jpba.2020.113109

Article  CAS  PubMed  Google Scholar 

Gritti F, David M, Brothy P, Lewis MR (2022) Model of retention time and density of gradient peak capacity for improved LC-MS method optimization: application to metabolomics. Anal Chim Acta 1197:339492. https://doi.org/10.1016/j.aca.2022.339492

Article  CAS  PubMed  Google Scholar 

ICH Steering Committee (2022) ICH Q2 (R2) validation of analytical procedures: method. In: Eur Agency Eval Med Prod Int Comm Harmon. https://www.ema.europa.eu/en/ich-q2r2-validation-analytical-procedures-scientific-guideline, Accessed 4/September/2024

Ivanović M, Krajnc P, Mlinarič A, Razboršek MI (2022) Natural deep eutectic solvent-based matrix solid phase dispersion (MSPD) extraction for determination of bioactive compounds from sandy everlasting (Helichrysum arenarium L.): a case of stability study. Plants 11:3468. https://doi.org/10.3390/plants11243468

Kanu AB (2021) Recent developments in sample preparation techniques combined with high-performance liquid chromatography: a critical review. J Chromatogr A 1654:462444. https://doi.org/10.1016/j.chroma.2021.462444

Article  CAS  PubMed  Google Scholar 

Kumar A, Rana R, Saklani R, Kumar M, Yadav K, Tiwari A, Chourasia MK (2023) Technology transfer of a validated RP-HPLC method for the simultaneous estimation of andrographolide and paclitaxel in application to pharmaceutical nanoformulation. J Chromatogr Sci 62:356–363. https://doi.org/10.1093/chromsci/bmad070

Article  CAS  Google Scholar 

Lee JS, Nam YR, Kim HJ, Kim WK (2023a) Quantification and validation of an HPLC method for low concentrations of apigenin-7-O-Glucuronide in Agrimonia pilosa aqueous ethanol extract topical cream by liquid-liquid extraction. Molecules 28:713. https://doi.org/10.3390/molecules28020713

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee TK, Hur G, Choi J, Ban C, Kim JY, Yang H, Park JHY, Lee KW, Kim JH (2023b) Enhancing stability and bioavailability of sulforaphene in radish seed extracts using nanoemulsion made with high oleic sunflower oil. Food Scien Biotech 32:1269–1279. https://doi.org/10.1007/s10068-023-01304-2

Article  CAS  Google Scholar 

Liao Y, Zhong L, Liu L, Xie L, Tang H, Zhang L, Li X (2020) Comparison of surfactants at solubilizing, forming and stabilizing nanoemulsion of hesperidin. J Food Eng 281:110000. https://doi.org/10.1016/j.jfoodeng.2020.110000

Article  CAS  Google Scholar 

Mahmoudi A, De Francia S, Paul P (2023) Development and validation of high-performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets. J Sep Sci 46:2300424. https://doi.org/10.1002/jssc.202300424

Article  CAS  Google Scholar 

Morais Fernandes J, Ortiz S, Padilha M. Tavares R, Mandova T, Araújo ERD, Andrade AWL, Michel S, Grougnet R, Zucolotto SM (2021) Bryophyllum pinnatum markers: CPC isolation, simultaneous quantification by a validated UPLC-DAD method and biological evaluations. J Pharm Biomed Anal 193:113682. https://doi.org/10.1016/j.jpba.2020.113682

Muniz VM, Chaves Júnior JV, Aragão CFS, de Souza FS, Sampaio FC (2023) A HPLC method for simultaneous quantification of chlorhexidine and thymol using Box-Behnken design for robustness of the method assessment. J Liq Chromatogr Relat Technol 46:168–179. https://doi.org/10.1080/10826076.2023.2227792

Article  CAS  Google Scholar 

Muzitano MF, Bergonzi MC, De Melo GO, Lage CLS, Bilia AR, Vincieri FF, Rossi-Bergmann B, Costa SS (2011) Influence of cultivation conditions, season of collection and extraction method on the content of antileishmanial flavonoids from Kalanchoe pinnata. J Ethnopharmacol 133:132–137. https://doi.org/10.1016/j.jep.2010.09.020

Article  CAS  PubMed  Google Scholar 

Nascimento LBDS, Leal-Costa MV, Menezes EA, Lopes VR, Muzitano MF, Costa SS, Tavares ES (2015) Ultraviolet-B radiation effects on phenolic profile and flavonoid content of Kalanchoe pinnata. J Photochem Photobiol B Biol 148:73–81. https://doi.org/10.1016/j.jphotobiol.2015.03.011

Article  CAS  Google Scholar 

Oroian M, Escriche I (2015) Antioxidants: characterization, natural sources, extraction and analysis. Food Res Int 74:10–36. https://doi.org/10.1016/j.foodres.2015.04.018

Article  CAS  PubMed  Google Scholar 

Pagano G, Talamanca AA, Castello G, Cordero MD, D’Ischia M, Gadaleta MN, Pallardó FV, Petrović S, Tiano L, Zatterale A (2014) Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: rational design of chemoprevention trials. Int J Mol Sci 15:20169–20208. https://doi.org/10.3390/ijms151120169

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K (2014) Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int 2014:2–20. https://doi.org/10.1155/2014/761264

Article  CAS  Google Scholar 

Ribeiro VP, Mejia JAA, Rodrigues DM, Alves GR, Pinheiro AMF, Tanimoto MH, Bastos JK, Ambrósio SR (2023) Brazilian brown propolis: an overview about its chemical composition, botanical sources, quality control, and pharmacological properties. Rev Bras Farmacogn 33:288–299. https://doi.org/10.1007/s43450-023-00374-x

Article  PubMed  PubMed Central