Pharmaceutical Potential of Jellyfish Derived Bioactive Compounds: Classification and Their Mechanism of Action

Ab Aziz NA, Salim N, Zarei M, Saari N, Yusoff FM (2021) Extraction, anti-tyrosinase, and antioxidant activities of the collagen hydrolysate derived from Rhopilema hispidum. Prep Biochem Biotechnol 51:44–53. https://doi.org/10.1080/10826068.2020.1789991

Article  CAS  PubMed  Google Scholar 

Addad S, Exposito JY, Faye C, Ricard-Blum S, Lethias C (2011) Isolation, characterization and biological evaluation of jellyfish collagen for use in biomedical applications. Mar Drugs 9:967–983. https://doi.org/10.3390/md9060967

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn EY, Hwang SJ, Choi MJ, Cho S, Lee HJ, Park Y (2018) Upcycling of jellyfish (Nemopilema nomurai) sea wastes as highly valuable reducing agents for green synthesis of gold nanoparticles and their antitumor and anti-inflammatory activity. Artif Cells Nanomed Biotechnol 46:1127–1136. https://doi.org/10.1080/21691401.2018.1480490

Article  CAS  PubMed  Google Scholar 

Alves C, Diederich M (2021) Marine natural products as anticancer agents. Mar Drugs 19:447. https://doi.org/10.3390/md19080447

Article  PubMed  PubMed Central  Google Scholar 

Amreen Nisa S, Vinu D, Krupakar P, Govindaraju K, Sharma D, Vivek R (2021) Jellyfish venom proteins and their pharmacological potentials: a review. Int J Biol Macromol 176:424–436. https://doi.org/10.1016/j.ijbiomac.2021.02.074

Article  CAS  PubMed  Google Scholar 

Andreosso A, Bansal PS, Smout MJ, Wilson D, Seymour JE, Daly NL (2018) Structural characterisation of predicted helical regions in the Chironex fleckeri CfTX-1 toxin. Mar Drugs 16:201. https://doi.org/10.3390/md16060201

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angilè F, Del Coco L, Girelli CR, Basso L, Rizzo L, Piraino S, Stabili L, Fanizzi FP (2020) 1H NMR metabolic profile of scyphomedusa Rhizostoma pulmo (scyphozoa, Cnidaria) in female gonads and somatic tissues: preliminary results. Molecules 25:806. https://doi.org/10.3390/molecules25040806

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayed Y, Sghaier RM, Laouini D, Bacha H (2016) Evaluation of anti-proliferative and anti-inflammatory activities of Pelagia noctiluca venom in lipopolysaccharide/interferon-γ stimulated RAW264.7 macrophages. Biomed Pharmacother 84:1986–1991. https://doi.org/10.1016/j.biopha.2016.11.010

Article  CAS  PubMed  Google Scholar 

Bakshani CR, Morales-Garcia AL, Althaus M, Wilcox MD, Pearson JP, Bythell JC, Burgess JG (2018) Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection. NPJ Biofilms Microbiomes 4:14. https://doi.org/10.1038/s41522-018-0057-2

Article  PubMed  PubMed Central  Google Scholar 

Balde A, Benjakul S, Kim SK, Nazeer RA (2023a) Development and in vitro effects of thiolated chitosan nanoparticles for the sustained delivery of inflammation suppressing bioactive peptide. J Drug Deliv Sci Technol 88:104971. https://doi.org/10.1016/j.jddst.2023.104971

Article  CAS  Google Scholar 

Balde A, Chatterjee A, Shukla S, Joshi I, Benjakul S, Kim SK, Nazeer RA (2023b) Purification and identification of bioactive oligopeptide from Indian halibut (Psettodes erumei) muscle tissue and its inflammation suppressing effect in vitro. Int J Pept Res Ther 29:80. https://doi.org/10.1007/s10989-023-10552-z

Article  CAS  Google Scholar 

Ballesteros A, Trullas C, Jourdan E, Gili JM (2022) Inhibition of nematocyst discharge from Pelagia noctiluca (Cnidaria: Scyphozoa)—prevention measures against jellyfish stings. Mar Drugs 20:571. https://doi.org/10.3390/md20090571

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barzideh Z, Latiff AA, Gan CY, Abedin MZ, Alias AK (2014) ACE inhibitory and antioxidant activities of collagen hydrolysates from the ribbon jellyfish (Chrysaora sp.). Food Technol Biotechnol 52:495–504. https://doi.org/10.17113/ftb.52.04.14.3641

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brinkman D, Burnell J (2007) Identification, cloning and sequencing of two major venom proteins from the box jellyfish, Chironex fleckeri. Toxicon 50:850–860. https://doi.org/10.1016/j.toxicon.2007.06.016

Article  CAS  PubMed  Google Scholar 

Brinkman DL, Burnell JN (2009) Biochemical and molecular characterisation of cubozoan protein toxins. Toxicon 54:1162–1173. https://doi.org/10.1016/j.toxicon.2009.02.006

Article  CAS  PubMed  Google Scholar 

Brinkman DL, Konstantakopoulos N, McInerney BV, Mulvenna J, Seymour JE, Isbister GK, Hodgson WC (2014) Chironex fleckeri (box jellyfish) venom proteins: expansion of a cnidarian toxin family that elicits variable cytolytic and cardiovascular effects. J Biol Chem 289:4798–4812. https://doi.org/10.1074/jbc.M113.534149

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cadar E, Pesterau AM, Sirbu R, Negreanu-Pirjol BS, Tomescu CL (2023) Jellyfishes-significant marine resources with potential in the wound-healing process: A review. Mar Drugs 21:201. https://doi.org/10.3390/md21040201

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao Y, Gao J, Zhang L, Qin N, Zhu B, Xia X (2021) Jellyfish skin polysaccharides enhance intestinal barrier function and modulate the gut microbiota in mice with DSS-induced colitis. Food Funct 12:10121–10135. https://doi.org/10.1039/d1fo02001c

Article  CAS  PubMed  Google Scholar 

Cariello L, Romano G, Spagnuolo A, Zanetti L (1988) Isolation and partial characterization of rhizolysin, a high molecular weight protein with hemolytic activity, from the jellyfish Rhizostoma pulmo. Toxicon 26:1057–1065. https://doi.org/10.1016/0041-0101(88)90204-8

Article  CAS  PubMed  Google Scholar 

Cegolon L, Heymann WC, Lange JH, Mastrangelo G (2013) Jellyfish stings and their management: a review. Mar Drugs 11:523–550. https://doi.org/10.3390/md11020523

Article  PubMed  PubMed Central  Google Scholar 

Chen Q, Kang J, Fu C (2018) The independence of and associations among apoptosis, autophagy, and necrosis. Signal Transduct Target Ther 3:18. https://doi.org/10.1038/s41392-018-0018-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Chen X, Ji Y, Zhang L, Wang W, Shen Y, Sun H (2022) A narrative review of the role of m6A in oxidative stress and inflammation. Biotarget 5:1. https://doi.org/10.21037/biotarget-21-1

Article  Google Scholar 

Cheong KL, Yu B, Chen J, Zhong S (2022) A comprehensive review of the cardioprotective effect of marine algae polysaccharide on the gut Microbiota. Foods 11:3550. https://doi.org/10.3390/foods11223550

Article  CAS  PubMed  PubMed Central  Google Scholar 

Collins AG (2002) Phylogeny of Medusozoa and the evolution of cnidarian life cycles: phylogeny of Medusozoa. J Evol Biol 15:418–432. https://doi.org/10.1046/j.1420-9101.2002.00403.x

Article  Google Scholar 

Cunha SA, Dinis-Oliveira RJ (2022) Raising awareness on the clinical and forensic aspects of jellyfish stings: a worldwide increasing threat. Int J Environ Res Public Health 19:8430. https://doi.org/10.3390/ijerph19148430

Article  CAS  PubMed  PubMed Central  Google Scholar 

Currie BJ, Jacups SP (2005) Prospective study of Chironex fleckeri and other box jellyfish stings in the “Top End” of Australia’s Northern Territory. Med J Aust 183:631–636. https://doi.org/10.5694/j.1326-5377.2005.tb00062.x

Article  PubMed  Google Scholar 

D’Ambra I, Lauritano C (2020) A review of toxins from Cnidaria. Mar Drugs 18:507. https://doi.org/10.3390/md18100507

Article  CAS  PubMed  PubMed Central 

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