Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, Cutting R, Ong K, Sallam H, Li TC. Recurrent implantation failure: definition and management. Reprod Biomed Online. 2014;28(1):14–38.

Article  CAS  PubMed  Google Scholar 

Busnelli A, Reschini M, Cardellicchio L, Vegetti W, Somigliana E, Vercellini P. How common is real repeated implantation failure? An indirect estimate of the prevalence. Reprod Biomed Online. 2020;40(1):91–7.

Article  PubMed  Google Scholar 

Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi HM, Ubaldi FM, Garcia-Velasco JA, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Hum Reprod. 2024;39(5):974–80.

Article  PubMed  Google Scholar 

Pirtea P, Cedars MI, Devine K, Ata B, Franasiak J, Racowsky C, Toner J, Scott RT, de Ziegler D, Barnhart KT. Recurrent implantation failure: reality or a statistical mirage?: Consensus statement from the July 1, 2022 Lugano Workshop on recurrent implantation failure. Fertil Steril. 2023;120(1):45–59.

Article  PubMed  Google Scholar 

Adamson GD, Dyer S, Zegers-Hochschild F, Chambers G, de Mouzon J, Ishihara O, Kupka MS, Baker V, Banker M, Elgindy EA, et al. O-154 ICMART preliminary world report 2019. Hum Reprod. 2023;38(1):i96–i97.

Google Scholar 

Li J, Chen Y, Liu C, Hu Y, Li L. Intravenous immunoglobulin treatment for repeated IVF/ICSI failure and unexplained infertility: a systematic review and a meta-analysis. Am J Reprod Immunol. 2013;70(6):434–47.

Article  CAS  PubMed  Google Scholar 

Failure EWGoRI, Cimadomo D, de los Santos MJ, Griesinger G, Lainas G, Le Clef N, McLernon DJ, Montjean D, Toth B, Vermeulen N et al. ESHRE good practice recommendations on recurrent implantation failure†. Human Reproduction Open. 2023(3):hoad023.

Chinese Association of Reproductive Medicine. Professional Committee of Reproductive Medicine, Association CMWs: Expert consensus on diagnosis and treatment of recurrent implantation failure. Natl Med J China. 2023;103(2):89–100.

Google Scholar 

Jin XH, Li Y, Li D. Intrauterine interventions for women with two or more implantation failures: A systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2022;13:959121.

Article  PubMed  Google Scholar 

Aleyasin A, Abediasl Z, Nazari A, Sheikh M. Granulocyte colony-stimulating factor in repeated IVF failure, a randomized trial. Reproduction. 2016;151(6):637–42.

Article  CAS  PubMed  Google Scholar 

Davari-Tanha F, ShahrokhTehraninejad E, Ghazi M, Shahraki Z. The role of G-CSF in recurrent implantation failure: A randomized double blind placebo control trial. Int J Reprod Biomed. 2016;14(12):737–42.

PubMed  PubMed Central  Google Scholar 

Eftekhar M, Miraj S, FaridMojtahedi M, Neghab N. Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial. Int J Reprod Biomed. 2016;14(11):687–90.

PubMed  PubMed Central  Google Scholar 

Arefi S, Fazeli E, Esfahani M, Borhani N, Yamini N, Hosseini A, Farifteh F. Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT. Int J Reprod Biomed. 2018;16(5):299–304.

CAS  PubMed  PubMed Central  Google Scholar 

Huang P, Yao C, Wei L, Lin Z. The intrauterine perfusion of granulocyte-colony stimulating factor (G-CSF) before frozen-thawed embryo transfer in patients with two or more implantation failures. Hum Fertil (Camb). 2020;2020(31):1–5.

Google Scholar 

Kalem Z, NamliKalem M, Bakirarar B, Kent E, Makrigiannakis A, Gurgan T. Intrauterine G-CSF administration in recurrent implantation failure (RIF): an Rct. Sci Rep. 2020;10(1):5139.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karimi A, Mokhtar S, Sadeghi M, Zafardoust S, Ataei M, Ghoodjani A, Mohazzab A, Nazari F, Ansaripour S. May intrauterine granulocyte colony stimulating factor improve clinical & ongoing pregnancy & live birth rates in unexplained repeated implantation failure patients? A randomized clinical trial. Eur J Mol Clin Med. 2020;7(2):82–7.

Google Scholar 

Torky H, El-Desouky E-S, El-Baz A, Aly R, El-Taher O, Shata A, Hussein A, Marie H, Deif O, Eldemery A. Effect of intrauterine granulocyte colony stimulating factor vs. human chorionic gonadotropin at ovum pick up day on pregnancy rate in IVF/ICSI cases with recurrent implantation failure. JBRA Assist Reprod. 2022;26(2):274–9.

PubMed  PubMed Central  Google Scholar 

Allahveisi A, Seyedoshohadaei F, Rezaei M, Bazrafshan N, Rahimi K. The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation. Heliyon. 2020;6(3):e03577.

Article  PubMed  PubMed Central  Google Scholar 

Nazari L, Salehpour S, Hosseini MS, HashemiMoghanjoughi P. The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial. Hum Fertil (Camb). 2020;23(3):209–13.

Article  PubMed  Google Scholar 

Zamaniyan M, Peyvandi S, HeidaryanGorji H, Moradi S, Jamal J. Yahya Poor Aghmashhadi F, Hossein Mohammadi M: Effect of platelet-rich plasma on pregnancy outcomes in infertile women with recurrent implantation failure: a randomized controlled trial. Gynecol Endocrinol. 2021;37(2):141–5.

Article  PubMed  Google Scholar 

Zargar M, Pazhouhanfar R, Najafian M. P C: Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures:a prospective randomized study. Clin Exp Obstet Gynecol. 2021;48(1):179–84.

Article  Google Scholar 

Safdarian L, Aleyasin A, Aghahoseini M, Lak P, Mosa SH, Sarvi F, Mahdavi A, Najafian A, Falahi P, Khazaei S. Efficacy of the intrauterine infusion of platelet-rich plasma on pregnancy outcomes in patients with repeated implantation failure: a randomized control trial. Int J Women’S Health Reprod. 2022;10(1):38–44.

Article  CAS  Google Scholar 

Baybordi E, Mohseni J, Mosapour P. The effect of platelet-rich plasma on the improvement of pregnancy results in repeated implantation failure: a randomized controlled trial. Int J Reprod Biomed. 2022;20(9):753–60.

CAS  PubMed  PubMed Central  Google Scholar 

El-Samman AAE-AM, Wafa YAS, Al-Omda FAF, Ali MAM. Autologous intrauterine platelet rich plasma instillation in repeated implantation failure in assisted reproductive techniques. Al-Azhar Int Med J. 2022;3(2):100–106.

Ershadi S, Noori N, Dashipoor A, Ghasemi M, Shamsa N. Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle. J Family Med Prim Care. 2022;11(5):2162–6.

Article  PubMed  PubMed Central  Google Scholar 

Nazari L, Salehpour S, Hosseini S, Sheibani S, Hosseinirad H. The effects of autologous platelet-rich plasma on pregnancy outcomes in repeated implantation failure patients undergoing frozen embryo transfer: a randomized controlled trial. Reprod Sci. 2022;29(3):993–1000.

Article  CAS  PubMed  Google Scholar 

Nazari L, Salehpour S, Hosseini S, Hashemi T, Borumandnia N, Azizi E. Effect of autologous platelet-rich plasma for treatment of recurrent pregnancy loss: a randomized controlled trial. Obstet Gynecol Sci. 2022;65(3):266–72.

Article  PubMed  PubMed Central  Google Scholar 

Huang P, Wei L, Li X. A study of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer after two or more implantation failures. Gynecol Endocrinol. 2017;33(1):67–9.

Article  CAS  PubMed  Google Scholar 

Wang M, Deng H, Ye H. Intrauterine injection of human chorionic gonadotrop in improves pregnancy outcome in patients with repeated implantation failure in frozen-thawed embryo transfer. J Cent South Univ (Med Sci). 2019;44(11):1247–51.

Google Scholar 

Mei J, Yan Y, Jiang R, Zhu YC, Ding L, Sun H. Clinical outcome of intrauterine administration of peripheral mononuclear cells or human chorionic gonadotropin in unexplained implantation failure. Am J Reprod Immunol. 2022;87(5):e13529.

Article  CAS  PubMed  Google Scholar 

Madkour A, Bouamoud N, Louanjli N, Kaarouch I, Copin H, Benkhalifa M, Sefrioui O. Intrauterine insemination of cultured peripheral blood mononuclear cells prior to embryo transfer improves clinical outcome for patients with repeated implantation failures. Zygote. 2016;24(1):58–69.

Article  CAS  PubMed  Google Scholar 

Yu N, Zhang B, Xu M, Wang S, Liu R, Wu J, Yang J, Feng L. Intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) activated by HCG improves the implantation and pregnancy rates in patients with repeated implantation failure: a prospective randomized study. Am J Reprod Immunol. 2016;76(3):212–6.

Article  CAS  PubMed  Google Scholar 

Nobijari FF, Arefi SS, Moini A, Taheripanah R, Fazeli E, Kharazi H, Hosseini SZ, Hosseini A, Valojerdi MR, Copin H, et al. Endometrium immunomodulation by intrauterine insemination administration of treated peripheral blood mononuclear cell prior frozen/thawed embryos in patients with repeated implantation failure. Zygote. 2019;27(4):214–8.

Article  CAS  PubMed  Google Scholar 

Pourmoghadam Z, Soltani-Zangbar MS, Sheikhansari G, Azizi R, Eghbal-Fard S, Mohammadi H, Siahmansouri H, Aghebati-Maleki L, Danaii S, Mehdizadeh A, et al. Intrauterine administration of autologous hCG- activated peripheral blood mononuclear cells improves pregnancy outcomes in patients with recurrent implantation failure; a double-blind, randomized control trial study. J Reprod Immunol. 2020;142:103182.

Article  CAS  PubMed