Irvine S, Cawood E, Richardson D, MacDonald E, Aitken J. Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years. BMJ. 1996;312(7029):467–71.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Haimov-Kochman R, Har-Nir R, Ein-Mor E, et al. Is the quality of donated semen deteriorating? Findings from a 15 year longitudinal analysis of weekly sperm samples. Isr Med Assoc J. 2012;14(6):372–7.

PubMed  Google Scholar 

Osadchuk LV, Osadchuk AV. Epidemiological studies of the male reproductive potential: sperm quality as a marker of reproductive health. Urologiia. 2020;3:111–20.

Article  Google Scholar 

Sharma R, Harlev A, Agarwal A, Esteves SC. Cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. Eur Urol. 2016;70(4):635–45.

Article  PubMed  Google Scholar 

Nassan FL, Chavarro JE, Tanrikut C. Diet and men’s fertility: does diet affect sperm quality? Fertil Steril. 2018;110(4):570–7.

Article  PubMed  Google Scholar 

Agarwal A, Sharma RK, Nallella KP, Thomas AJ Jr, Alvarez JG, Sikka SC. Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril. 2006;86(4):878–85.

Article  PubMed  CAS  Google Scholar 

Imran Afridi H, Gul Kazi T, NazTalpur F, Ahmed Baig J, Qadir CG. Essential trace and toxic elemental concentrations in biological samples of male adult referent and Eunuch subjects. Clin Chim Acta. 2022;529:96–103.

Article  PubMed  CAS  Google Scholar 

Zargari F, Rahaman MS, KazemPour R, Hajirostamlou M. Arsenic, Oxidative stress and reproductive system. J Xenobiot. 2022;12(3):214–22.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yin T, Yue X, Li Q, et al. The association between the levels of oxidative stress indicators (MDA, SOD, and GSH) in seminal plasma and the risk of idiopathic oligo-asthenotera-tozoospermia: does Cu or Se level alter the association? Biol Trace Elem Res. 2024;202(7):2941–53.

Article  PubMed  CAS  Google Scholar 

Guo H, Ouyang Y, Yin H, et al. Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder. Redox Biol. 2022;49:102227.

Article  PubMed  CAS  Google Scholar 

Fallah F, Colagar AH, Saleh HA, Ranjbar M. Variation of the genes encoding antioxidant enzymes SOD2 (rs4880), GPX1 (rs1050450), and CAT (rs1001179) and susceptibility to male infertility: a genetic association study and in silico analysis. Environ Sci Pollut Res Int. 2023;30(36):86412–24.

Article  PubMed  CAS  Google Scholar 

Finelli R, Mottola F, Agarwal A. Impact of alcohol consumption on male fertility potential: a narrative review. Int J Environ Res Public Health. 2021;19(1):328.

Article  PubMed  PubMed Central  Google Scholar 

Millwood IY, Walters RG, Mei XW, et al. Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China. Lancet. 2019;393(10183):1831–42.

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Fu L. The role of ALDH2 in tumorigenesis and tumor progression: targeting ALDH2 as a potential cancer treatment. Acta Pharm Sin B. Jun2021;11(6):1400–11.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ferguson RA, Goldberg DM. Genetic markers of alcohol abuse. Clin Chim Acta. 1997;257(2):199–250.

Article  PubMed  CAS  Google Scholar 

Edenberg HJ, Foroud T. Genetics and alcoholism. Nat Rev Gastroenterol Hepatol. 2013;10(8):487–94.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nguyen-Thanh T, Hoang-Thi AP, Anh Thu DT. Investigating the association between alcohol intake and male reproductive function: a current meta-analysis. Heliyon. 2023;9(5):e15723.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang Z, Cheng J, Yang L, et al. The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity. Free Radic Biol Med. 2023;200:26–35.

Article  PubMed  CAS  Google Scholar 

Zenzes MT. Smoking and reproduction: gene damage to human gametes and embryos. Hum Reprod Update Mar-Apr. 2000;6(2):122–31.

Article  CAS  Google Scholar 

La Maestra S, De Flora S, Micale RT. Effect of cigarette smoke on DNA damage, oxidative stress, and morphological alterations in mouse testis and spermatozoa. Int J Hyg Environ Health. 2015;218(1):117–22.

Article  PubMed  Google Scholar 

Ishii T, Matsuse T, Teramoto S, et al. Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease. Thorax. 1999;54:693–6.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lakhdar R, Denden S, Knani J, et al. Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population. Genet Mol Res. 2010;9(2):897–907.

Article  PubMed  CAS  Google Scholar 

Zimniak P, Nanduri B, Pikuła S, et al. Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur J Biochem. 1994;224(3):893–9.

Article  PubMed  CAS  Google Scholar 

Koh WP, Nelson HH, Yuan JM, et al. Glutathione S-transferase (GST) gene polymorphisms, cigarette smoking and colorectal cancer risk among Chinese in Singapore. Carcinogenesis. 2011;32(10):1507–11.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tian M, Bao H, Martin FL, et al. Association of DNA methylation and mitochondrial DNA copy number with human semen quality. Biol Reprod. 2014;91(4):101.

Article  PubMed  Google Scholar 

Zhang H, He J, Zhao Y, et al. Effect of glutathione S-transferase gene polymorphisms on semen quality in patients with idiopathic male infertility. J Int Med Res. 2021;49(12):3000605211061045.

Article  PubMed  CAS  Google Scholar 

Cao W, Cai L, Rao JY, et al. Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma. Cancer. 2005;104(11):2400–8.

Article  PubMed  CAS  Google Scholar 

Ozgur K, Isikoglu M, Seleker M, Donmez L. Semen quality of smoking and non-smoking men in infertile couples in a Turkish population. Arch Gynecol Obstet. 2005;271(2):109–12.

Article  PubMed  Google Scholar 

Li Y, Lin H, Ma M, et al. Semen quality of 1346 healthy men, results from the Chongqing area of southwest China. Hum Reprod. 2009;24(2):459–69.

Article  PubMed  CAS  Google Scholar 

World Health O. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization; 2010.

Google Scholar 

Amor H, Hammadeh ME, Mohd I, Jankowski PM. Impact of heavy alcohol consumption and cigarette smoking on sperm DNA integrity. Andrologia. 2022;54(7):e14434.

Article  PubMed  CAS  Google Scholar 

Rogers BJ, Cash MK, Vaughn WK. Ethanol inhibits human and hamster sperm penetration of eggs. Gamete Res. 1987;16(2):97–107.

Article  PubMed  CAS