Munné S, Alikani M, Tomkin G, Grifo J, Cohen J. Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. Fertil Steril. 1995;64(2):382–91.

Article  PubMed  Google Scholar 

Charalambous C, Webster A, Schuh M. Aneuploidy in mammalian oocytes and the impact of maternal ageing. Nat Rev Mol Cell Biol. 2023;24(1):27–44.

Article  CAS  PubMed  Google Scholar 

Quenby S, Gallos ID, Dhillon-Smith RK, Podesek M, Stephenson MD, Fisher J, et al. Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss. Lancet. 2021;397(10285):1658–67.

Article  CAS  PubMed  Google Scholar 

Tan SL, Royston P, Campbell S, Jacobs HS, Betts J, Mason B, et al. Cumulative conception and livebirth rates after in-vitro fertilisation. Lancet. 1992;339(8806):1390–4.

Article  CAS  PubMed  Google Scholar 

Navot D, Bergh PA, Williams MA, Garrisi GJ, Guzman I, Sandler B, et al. Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility. Lancet. 1991;337(8754):1375–7.

Article  CAS  PubMed  Google Scholar 

Doherty CA, Amargant F, Shvartsman SY, Duncan FE, Gavis ER. Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila. Trends Cell Biol. 2022;32(4):311–23.

Article  CAS  PubMed  Google Scholar 

Richani D, Dunning KR, Thompson JG, Gilchrist RB. Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence. Hum Reprod Update. 2021;27(1):27–47.

Article  CAS  PubMed  Google Scholar 

McReynolds S, Dzieciatkowska M, McCallie BR, Mitchell SD, Stevens J, Hansen K, et al. Impact of maternal aging on the molecular signature of human cumulus cells. Fertil Steril. 2012;98(6):1574-80.e5.

Article  CAS  PubMed  Google Scholar 

Babayev E, Suebthawinkul C, Gokyer D, Parkes WS, Rivas F, Pavone ME, et al. Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan. Aging Cell. 2023;22(11):e14004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ben-Meir A, Kim K, McQuaid R, Esfandiari N, Bentov Y, Casper RF, et al. Co-enzyme Q10 supplementation rescues cumulus cells dysfunction in a maternal aging model. Antioxidants (Basel). 2019; 8(3).

Chiang JL, Shukla P, Pagidas K, Ahmed NS, Karri S, Gunn DD, et al. Mitochondria in ovarian aging and reproductive longevity. Ageing Res Rev. 2020;63:101168.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pacella-Ince L, Zander-Fox DL, Lan M. Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age. Hum Reprod. 2014;29(7):1490–9.

Article  CAS  PubMed  Google Scholar 

Pileggi CA, Parmar G, Harper ME. The lifecycle of skeletal muscle mitochondria in obesity. Obes Rev. 2021;22(5):e13164.

Article  CAS  PubMed  Google Scholar 

Pernas L, Scorrano L. Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function. Annu Rev Physiol. 2016;78:505–31.

Article  CAS  PubMed  Google Scholar 

Wai T, Langer T. Mitochondrial dynamics and metabolic regulation. Trends Endocrinol Metab. 2016;27(2):105–17.

Article  CAS  PubMed  Google Scholar 

Ni HM, Williams JA, Ding WX. Mitochondrial dynamics and mitochondrial quality control. Redox Biol. 2015;4:6–13.

Article  CAS  PubMed  Google Scholar 

Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, et al. Mitochondria bound to lipid droplets have unique bioenergetics, composition, and dynamics that support lipid droplet expansion. Cell Metab. 2018;27(4):869-85.e6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liesa M, Shirihai OS. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. 2013;17(4):491–506.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu X, Liu Y, Xu J, Cao X, Zhang D, Liu M, et al. Mitochondrial dysfunction in cumulus cells is related to decreased reproductive capacity in advanced-age women. Fertil Steril. 2022;118(2):393–404.

Article  CAS  PubMed  Google Scholar 

Jiang Z, Shi C, Han H, Wang Y, Liang R, Chen X, et al. Mitochondria-related changes and metabolic dysfunction in low prognosis patients under the POSEIDON classification. Hum Reprod. 2021;36(11):2904–15.

Article  CAS  PubMed  Google Scholar 

Palmer CS, Osellame LD, Stojanovski D, Ryan MT. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Cell Signal. 2011;23(10):1534–45.

Article  CAS  PubMed  Google Scholar 

Kleele T, Rey T, Winter J, Zaganelli S, Mahecic D, Perreten Lambert H, et al. Distinct fission signatures predict mitochondrial degradation or biogenesis. Nature. 2021;593(7859):435–9.

Article  CAS  PubMed  Google Scholar 

Ul Fatima N, Ananthanarayanan V. Mitochondrial movers and shapers: recent insights into regulators of fission, fusion and transport. Curr Opin Cell Biol. 2023;80:102150.

Article  CAS  PubMed  Google Scholar 

Adebayo M, Singh S, Singh AP, Dasgupta S. Mitochondrial fusion and fission: the fine-tune balance for cellular homeostasis. Faseb j. 2021;35(6):e21620.

Article  CAS  PubMed  Google Scholar 

Eisner V, Picard M, Hajnóczky G. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses. Nat Cell Biol. 2018;20(7):755–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ryu KW, Fung TS, Baker DC, Saoi M, Park J, Febres-Aldana CA, et al. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature. 2024;635(8039):746–54.

Article  CAS  PubMed  Google Scholar 

Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, et al. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature. 2023;622(7983):627–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawless C, et al. Quantitative 3D mapping of the human skeletal muscle mitochondrial network. Cell Rep. 2019;26(4):996-1009.e4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faitg J, Lacefield C, Davey T, White K, Laws R, Kosmidis S, et al. 3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus. Cell Rep. 2021;36(6):109509.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Vallée J, et al. Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice. Oncotarget. 2015;6(20):17923–37.

Article  PubMed  PubMed Central  Google Scholar 

Veeck LL: An atlas of human gametes and conceptuses: an illustrated reference for assisted reproductive technology. CRC Press; 1999.

Chaudhry A, Shi R, Luciani DS. A pipeline for multidimensional confocal analysis of mitochondrial morp