Manzoor S, Gabr MT, Nafie MS, Raza MK, Khan A, Nayeem SM, et al. Discovery of quinolinone hybrids as dual inhibitors of acetylcholinesterase and abeta aggregation for Alzheimer’s disease therapy. ACS Chem Neurosci. 2024;15:539–59. https://doi.org/10.1021/acschemneuro.3c00588
Article PubMed CAS Google Scholar
Samarelli F, Purgatorio R, Lopopolo G, Deruvo C, Catto M, Andresini M, et al. Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults. Eur J Med Chem. 2024;270:116353. https://doi.org/10.1016/j.ejmech.2024.116353
Article PubMed CAS Google Scholar
Choubey PK, Tripathi A, Tripathi MK, Seth A, Shrivastava SK. Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer’s disease. Bioorg Chem. 2021;111:104922. https://doi.org/10.1016/j.bioorg.2021.104922
Article PubMed CAS Google Scholar
Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, et al. Discovery of a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with antioxidant activity that alleviates alzheimer-like pathology in old APP/PS1 mice. J Med Chem. 2021;64:812–39. https://doi.org/10.1021/acs.jmedchem.0c01775
Article PubMed CAS Google Scholar
Waiker DK, Verma A, Akhilesh AGT, Singh N, Roy A, et al. Design, synthesis, and biological evaluation of piperazine and N-benzylpiperidine hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as potential multitargeted ligands for Alzheimer’s disease therapy. ACS Chem Neurosci. 2023;14:2217–42. https://doi.org/10.1021/acschemneuro.3c00245
Article PubMed CAS Google Scholar
Banoo R, Nuthakki VK, Wadje BN, Sharma A, Bharate SB. Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood-brain barrier permeable dual cholinesterase and beta-secretase inhibitors. Eur J Med Chem. 2024;266:116131. https://doi.org/10.1016/j.ejmech.2024.116131
Article PubMed CAS Google Scholar
Bowroju SK, Penthala NR, Lakkaniga NR, Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ, et al. Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease. Bioorg Med Chem. 2021;45:116311. https://doi.org/10.1016/j.bmc.2021.116311
Article PubMed PubMed Central CAS Google Scholar
Umar T, Shalini S, Raza MK, Gusain S, Kumar J, Seth P, et al. A multifunctional therapeutic approach: synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer’s disease. Eur J Med Chem. 2019;175:2–19. https://doi.org/10.1016/j.ejmech.2019.04.038
Article PubMed CAS Google Scholar
Jiang N, Ding J, Liu J, Sun X, Zhang Z, Mo Z, et al. Novel chromanone-dithiocarbamate hybrids as multifunctional AChE inhibitors with beta-amyloid anti-aggregation properties for the treatment of Alzheimer’s disease. Bioorg Chem. 2019;89:103027. https://doi.org/10.1016/j.bioorg.2019.103027
Article PubMed CAS Google Scholar
Xu M, Peng Y, Zhu L, Wang S, Ji J, Rakesh KP. Triazole derivatives as inhibitors of Alzheimer’s disease: current developments and structure-activity relationships. Eur J Med Chem. 2019;180:656–72. https://doi.org/10.1016/j.ejmech.2019.07.059
Article PubMed CAS Google Scholar
Dong S, Xia J, Wang F, Yang L, Xing S, Du J, et al. Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer’s disease. Eur J Med Chem. 2024;264:116013. https://doi.org/10.1016/j.ejmech.2023.116013
Article PubMed CAS Google Scholar
Xu Y, Zhang J, Wang H, Mao F, Bao K, Liu W, et al. Rational design of novel selective dual-target inhibitors of acetylcholinesterase and monoamine oxidase B as potential anti-Alzheimer’s disease agents. ACS Chem Neurosci. 2019;10:482–96. https://doi.org/10.1021/acschemneuro.8b00357
Article PubMed CAS Google Scholar
Tan A, Almaz Z. A series of 1,2,3-triazole compounds: synthesis, characterization, and investigation of the cholinesterase inhibitory properties via in vitro and in silico studies. J Mol Struct. 2023;1277:134854. https://doi.org/10.1016/j.molstruc.2022.134854
Li X, Li T, Zhan F, Cheng F, Lu L, Zhang B, et al. Design, synthesis, and biological evaluation of novel chromanone derivatives as multifunctional agents for the treatment of Alzheimer’s disease. ACS Chem Neurosci. 2022;13:3488–501. https://doi.org/10.1021/acschemneuro.2c00520
Article PubMed CAS Google Scholar
Wang L, Sun T, Zhen T, Li W, Yang H, Wang S, et al. Butyrylcholinesterase-activated near-infrared fluorogenic probe for in vivo theranostics of Alzheimer’s disease. J Med Chem. 2024;67:6793–809. https://doi.org/10.1021/acs.jmedchem.4c00355
Article PubMed CAS Google Scholar
Li Q, Chen Y, Xing S, Liao Q, Xiong B, Wang Y, et al. Highly potent and selective butyrylcholinesterase inhibitors for cognitive improvement and neuroprotection. J Med Chem. 2021;64:6856–76. https://doi.org/10.1021/acs.jmedchem.1c00167
Article PubMed CAS Google Scholar
Chen T, Sang S, Wei Y, Ge Y, Jin J, Bian Y, et al. The structural modification and biological evaluation of tetrahydrothienopyridine derivatives as selective BChE inhibitors. Bioorg Med Chem Lett. 2023;93:129436. https://doi.org/10.1016/j.bmcl.2023.129436
Article PubMed CAS Google Scholar
Pidany F, Kroustkova J, Al Mamun A, Suchankova D, Brazzolotto X, Nachon F, et al. Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - design, synthesis, and biological evaluation. Eur J Med Chem. 2023;252:115301. https://doi.org/10.1016/j.ejmech.2023.115301
Article PubMed CAS Google Scholar
Zhou Y, Lu X, Du C, Liu Y, Wang Y, Hong KH, et al. Novel BuChE-IDO1 inhibitors from sertaconazole: virtual screening, chemical optimization and molecular modeling studies. Bioorg Med Chem Lett. 2021;34:127756. https://doi.org/10.1016/j.bmcl.2020.127756
Article PubMed CAS Google Scholar
Rehuman NA, Oh JM, Nath LR, Khames A, Abdelgawad MA, Gambacorta N, et al. Halogenated coumarin-chalcones as multifunctional monoamine oxidase-B and butyrylcholinesterase inhibitors. ACS Omega. 2021;6:28182–93. https://doi.org/10.1021/acsomega.1c04252
Article PubMed PubMed Central CAS Google Scholar
Bajda M, Latka K, Hebda M, Jonczyk J, Malawska B. Novel carbamate derivatives as selective butyrylcholinesterase inhibitors. Bioorg Chem. 2018;78:29–38. https://doi.org/10.1016/j.bioorg.2018.03.003
Article PubMed CAS Google Scholar
Liu D, Zhang H, Wang Y, Liu W, Yin G, Wang D, et al. Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer’s disease. Eur J Med Chem. 2022;229:114044. https://doi.org/10.1016/j.ejmech.2021.114044
Article PubMed CAS Google Scholar
Waly OM, Saad KM, El-Subbagh HI, Bayomi SM, Ghaly MA. Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer’s agents. Eur J Med Chem. 2022;231:114152. https://doi.org/10.1016/j.ejmech.2022.114152
Article PubMed CAS Google Scholar
Sharma P, Tripathi A, Tripathi PN, Singh SS, Singh SP, Shrivastava SK. Novel molecular hybrids of N-benzylpiperidine and 1,3,4-oxadiazole as multitargeted therapeutics to treat Alzheimer’s disease. ACS Chem Neurosci. 2019;10:4361–84. https://doi.org/10.1021/acschemneuro.9b00430
Article PubMed CAS Google Scholar
Çakmak R, Başaran E, Ercan S, Boğa M, Çınar E, Topal G. Synthesis of new fluorinated sulfonates and their Schiff bases as anti-Alzheimer drug candidates: an in vitro-in silico study. J Mol Struct. 2025;1329:141474. https://doi.org/10.1016/j.molstruc.2025.141474
ÇInar E, BoĞA M, Topal G, ÇAkmak R. Some novel Schiff base derivatives as promising cholinesterase inhibitors with antioxidant activity against Alzheimer’s disease: synthesis, characterization and biological evaluation. Middle East J Sci. 2022;8:138–46. https://doi.org/10.51477/mejs.1204413
Çakmak R, Ay B, Çınar E, Başaran E, Akkoç S, Boğa M, et al. Synthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn(II), and Ru(III) complexes of pyrazolone-based Schiff base ligand. J Mol Struct. 2023;1292:136225. https://doi.org/10.1016/j.molstruc.2023.136225
Reşit Ç, Başaran E, Boğa M, Erdoğan Ö, Çınar E, Çevik Ö. Schiff base derivatives of 4-aminoantipyrine as promising molecules: synthesis, structural characterization, and biological activities. Russ J Bioorg Chem. 2022;48:334–44. https://doi.org/10.1134/s1068162022020182
Patel DV, Patel NR, Kanhed AM, Patel SP, Sinha A, Kansara DD, et al. Novel multitarget directed triazinoindole derivatives as anti-alzheimer agents. ACS Chem Neurosci. 2019;10:3635–61. https://doi.org/10.1021/acschemneuro.9b00226
Comments (0)