Asherman Syndrome: An Updated Review on Diagnosis, Management, and Pregnancy Outcomes

Fritsch H. Ein Fall von volligen schwund der Gebaumutterhohle nach Auskratzung. Zentralbl Gynaekol. 1894;18:1337–42.

Google Scholar 

Asherman JG. Amenorrhoea traumatica (atretica). J Obstet Gynaecol Br Emp. 1948;55(1):23–30. https://doi.org/10.1111/j.1471-0528.1948.tb07045.x.

Article  CAS  PubMed  Google Scholar 

Asherman JG. Traumatic intra-uterine adhesions. J Obstet Gynaecol Br Emp. 1950;57(6):892–6. https://doi.org/10.1111/j.1471-0528.1950.tb06053.x.

Article  CAS  PubMed  Google Scholar 

AAGL Elevating Gynecologic Surgery. AAGL practice report: practice guidelines on intrauterine adhesions developed in collaboration with the European Society of Gynaecological Endoscopy (ESGE). J Minim Invasive Gynecol. 2017;24(5):695–705. https://doi.org/10.1016/j.jmig.2016.11.008.

Article  Google Scholar 

Yu D, Wong YM, Cheong Y, Xia E, Li TC. Asherman syndrome–one century later. Fertil Steril. 2008;89(4):759–79. https://doi.org/10.1016/j.fertnstert.2008.02.096.

Article  PubMed  Google Scholar 

Hanstede MM, van der Meij E, Goedemans L, Emanuel MH. Results of centralized Asherman surgery, 2003–2013. Fertil Steril. 2015;104(6):1561-8 e1. https://doi.org/10.1016/j.fertnstert.2015.08.039.

Article  PubMed  Google Scholar 

Deans R, Abbott J. Review of intrauterine adhesions. J Minim Invasive Gynecol. 2010;17(5):555–69. https://doi.org/10.1016/j.jmig.2010.04.016.

Article  PubMed  Google Scholar 

Schenker JG, Margalioth EJ. Intrauterine adhesions: an updated appraisal. Fertil Steril. 1982;37(5):593–610. https://doi.org/10.1016/s0015-0282(16)46268-0.

Article  CAS  PubMed  Google Scholar 

Khan Z. Etiology, risk factors, and management of Asherman syndrome. Obstet Gynecol. 2023;142(3):543–54. https://doi.org/10.1097/AOG.0000000000005309.

Article  PubMed  Google Scholar 

Harzif AK, Anggraeni TD, Syaharutsa DM, Hellyanti T. Hysteroscopy role for female genital tuberculosis. Gynecol Minim Invasive Ther. 2021;10(4):243–6. https://doi.org/10.4103/GMIT.GMIT_151_20.

Article  PubMed  PubMed Central  Google Scholar 

Taskin O, Sadik S, Onoglu A, et al. Role of endometrial suppression on the frequency of intrauterine adhesions after resectoscopic surgery. J Am Assoc Gynecol Laparosc. 2000;7(3):351–4. https://doi.org/10.1016/s1074-3804(05)60478-1.

Article  CAS  PubMed  Google Scholar 

Yu X, Yuhan L, Dongmei S, Enlan X, Tinchiu L. The incidence of post-operative adhesion following transection of uterine septum: a cohort study comparing three different adjuvant therapies. Eur J Obstet Gynecol Reprod Biol. 2016;201:61–4. https://doi.org/10.1016/j.ejogrb.2016.01.039.

Article  PubMed  Google Scholar 

Jain V, Chodankar RR, Maybin JA, Critchley HOD. Uterine bleeding: how understanding endometrial physiology underpins menstrual health. Nat Rev Endocrinol. 2022;18(5):290–308. https://doi.org/10.1038/s41574-021-00629-4.

Article  PubMed  PubMed Central  Google Scholar 

Cousins FL, Filby CE, Gargett CE. Endometrial stem/progenitor cells-their role in endometrial repair and regeneration. Front Reprod Health. 2021;3:811537. https://doi.org/10.3389/frph.2021.811537.

Article  PubMed  Google Scholar 

Benor A, Gay S, DeCherney A. An update on stem cell therapy for Asherman syndrome. J Assist Reprod Genet. 2020;37(7):1511–29. https://doi.org/10.1007/s10815-020-01801-x.

Article  PubMed  PubMed Central  Google Scholar 

Lee WL, Liu CH, Cheng M, Chang WH, Liu WM, Wang PH. Focus on the primary prevention of intrauterine adhesions: current concept and vision. Int J Mol Sci. 2021;22(10):5175. https://doi.org/10.3390/ijms22105175.

Article  PubMed  PubMed Central  Google Scholar 

Deans R, Moses D, Sach TA, Vancaillie T, Ledger B, Abbott JA. Perfusion magnetic resonance imaging in Asherman syndrome. Aust N Z J Obstet Gynaecol. 2024;64(4):341–6. https://doi.org/10.1111/ajo.13799.

Article  PubMed  Google Scholar 

Hanstede MMF, van der Meij E, Veersema S, Emanuel MH. Live births after Asherman syndrome treatment. Fertil Steril. 2021;116(4):1181–7. https://doi.org/10.1016/j.fertnstert.2021.05.099.

Article  PubMed  Google Scholar 

Hinckley MD, Milki AA. 1000 office-based hysteroscopies prior to in vitro fertilization: feasibility and findings. JSLS. 2004;8(2):103–7. (https://www.ncbi.nlm.nih.gov/pubmed/15119651). Accessed Oct 2024.

Hooker AB, Lemmers M, Thurkow AL, et al. Systematic review and meta-analysis of intrauterine adhesions after miscarriage: prevalence, risk factors and long-term reproductive outcome. Hum Reprod Update. 2014;20(2):262–78. https://doi.org/10.1093/humupd/dmt045.

Article  CAS  PubMed  Google Scholar 

Yucebilgin MS, Aktan E, Bozkurt K, et al. Comparison of hydrosonography and diagnostic hysteroscopy in the evaluation of infertile patients. Clin Exp Obstet Gynecol. 2004;31(1):56–8. (https://www.ncbi.nlm.nih.gov/pubmed/14998191). Accessed Oct 2024.

Zhu R, Gan L, Wang S, Duan H. A cohort study comparing the severity and outcome of intrauterine adhesiolysis for Asherman syndrome after first- or second-trimester termination of pregnancy. Eur J Obstet Gynecol Reprod Biol. 2019;238:49–53. https://doi.org/10.1016/j.ejogrb.2019.02.030.

Article  PubMed  Google Scholar 

Hooker AB, Mansvelder FJ, Elbers RG, Frijmersum Z. Reproductive outcomes in women with mild intrauterine adhesions; a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2022;35(25):6933–41. https://doi.org/10.1080/14767058.2021.1931103.

Article  PubMed  Google Scholar 

Hooker A, Fraenk D, Brolmann H, Huirne J. Prevalence of intrauterine adhesions after termination of pregnancy: a systematic review. Eur J Contracept Reprod Health Care. 2016;21(4):329–35. https://doi.org/10.1080/13625187.2016.1199795.

Article  PubMed  Google Scholar 

Barel O, Krakov A, Pansky M, Vaknin Z, Halperin R, Smorgick N. Intrauterine adhesions after hysteroscopic treatment for retained products of conception: what are the risk factors? Fertil Steril. 2015;103(3):775–9. https://doi.org/10.1016/j.fertnstert.2014.11.016.

Article  PubMed  Google Scholar 

Zhang W, French H, O’Brien M, Movilla P, Isaacson K, Morris S. Incidence of intrauterine adhesions after hysteroscopic myomectomy in patients seeking fertility. J Minim Invasive Gynecol. 2023;30(10):805–12. https://doi.org/10.1016/j.jmig.2023.05.013.

Article  PubMed  Google Scholar 

Seshadri S, El-Toukhy T, Douiri A, Jayaprakasan K, Khalaf Y. Diagnostic accuracy of saline infusion sonography in the evaluation of uterine cavity abnormalities prior to assisted reproductive techniques: a systematic review and meta-analyses. Hum Reprod Update. 2015;21(2):262–74. https://doi.org/10.1093/humupd/dmu057.

Article  CAS  PubMed  Google Scholar 

Ding C, Wei W, Ding F, Ding J, Li B, Ma Q. Ultrasound diagnostic of intrauterine adhesions: Systematic review and meta-analysis. J Obstet Gynaecol Res. 2024. https://doi.org/10.1111/jog.16027.

Article  PubMed  Google Scholar 

Huang R, Huang X, Li S, et al. Value of 2D ultrasonography in the diagnosis and evaluation of intrauterine adhesions - a prospective study. Reprod Biomed Online. 2024;49(2):103771. https://doi.org/10.1016/j.rbmo.2023.103771.

Article  PubMed  Google Scholar 

Cao M, Pan Y, Zhang Q, You D, Feng S, Liu Z. Predictive value of live birth rate based on different intrauterine adhesion evaluation systems following TCRA. Reprod Biol Endocrinol. 2021;19(1):13. https://doi.org/10.1186/s12958-021-00697-1.

Article  PubMed  PubMed Central  Google Scholar 

Yang L, Wang L, Chen Y, et al. Cold scissors versus electrosurgery for hysteroscopic adhesiolysis: A meta-analysis. Medicine (Baltimore). 2021;100(17):e25676. https://doi.org/10.1097/MD.0000000000025676.

Article  PubMed  Google Scholar 

Tang R, Zhang W, Xiao X, Li W, Chen X, Wang X. Intrauterine interventions options for preventing recurrence after hysteroscopic adhesiolysis: a systematic review and network meta-analysis of randomized controlled trials. Arch Gynecol Obstet. 2024;309(5):1847–61. https://doi.org/10.1007/s00404-024-07460-y.

Article  PubMed 

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