Calcimimetics or parathyroidectomy for kidney transplant recipients: is there still a question? a systematic review, meta-analysis and trial sequential analysis

P. Messa, C.M. Alfieri, Secondary and Tertiary Hyperparathyroidism. Frontiers Hormone Research 51, 91–108 (2019). https://doi.org/10.1159/000491041

Article  CAS  Google Scholar 

L.-X. Zhang et al. Advances in the treatment of secondary and tertiary hyperparathyroidism. Front. Endocrinol. 13(Dec), 1059828 (2022). https://doi.org/10.3389/fendo.2022.1059828

Article  Google Scholar 

M. Mizobuchi, H. Ogata, F. Koiwa, Secondary Hyperparathyroidism: pathogenesis and Latest Treatment. Ther. Apher. Dial. 23(4 Aug), 309–318 (2019). https://doi.org/10.1111/1744-9987.12772

Article  PubMed  Google Scholar 

R. Iezzi et al. Interventional radiological treatment of renal transplant complications: a pictorial Review. Korean J. Radiol. 16(3 Jun), 593 (2015). https://doi.org/10.3348/kjr.2015.16.3.593

Article  PubMed  PubMed Central  Google Scholar 

V. Palumbo, G. Damiano, M. Messina, Tertiary hyperparathyroidism: a review. Clin. Ter. 172(3 Apr), 241–246 (2021). https://doi.org/10.7417/CT.2021.2322

Article  CAS  PubMed  Google Scholar 

W. Sutton et al. Prevalence and risk factors for tertiary hyperparathyroidism in kidney transplant recipients. Surgery 171(1 Jan), 69–76 (2022). https://doi.org/10.1016/j.surg.2021.03.067

Article  PubMed  Google Scholar 

M. Chandran, J. Wong, Secondary and tertiary hyperparathyroidism in chronic kidney disease: an endocrine and renal perspective. Indian. J. Endocrinol. Metab. 23(4), 391–399, (2019). https://doi.org/10.4103/ijem.IJEM_292_19

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y.R. Somnay, E. Weinlander, D.F. Schneider, R.S. Sippel, H. Chen, The effect of cinacalcet (sensipar®) on intraoperative findings in tertiary hyperparathyroidism patients undergoing parathyroidectomy. Surgery 156(6 Dec), 1308–1314 (2014). https://doi.org/10.1016/j.surg.2014.08.003

Article  PubMed  Google Scholar 

S. Frey et al. Parathyroidectomy or cinacalcet: do we still not know the best option for graft function in kidney-transplanted patients? a meta-analysis. Surgery 170(3 Sep), 727–735 (2021). https://doi.org/10.1016/j.surg.2021.02.048

Article  PubMed  Google Scholar 

R.R. Dulfer, G.J.H. Franssen, D.A. Hesselink, E.J. Hoorn, C.H.J. Van Eijck, T.M. Van Ginhoven, Systematic review of surgical and medical treatment for tertiary hyperparathyroidism. Br. J. Surg. 104(7 May), 804–813 (2017). https://doi.org/10.1002/bjs.10554

Article  CAS  PubMed  Google Scholar 

A.R. Soliman, H.A. Maamoun, M.A. Soliman, H. Darwish, E. Elbanna, Cinacalcet versus Parathyroidectomy in the Treatment of Secondary Hyperparathyroidism Post Renal Transplantation. Rom. J. Intern. Med. 54(3 Sep), 184–189 (2016). https://doi.org/10.1515/rjim-2016-0027

Article  PubMed  Google Scholar 

J.M. Cruzado et al. A randomized study comparing parathyroidectomy with cinacalcet for treating hypercalcemia in kidney allograft recipients with hyperparathyroidism. J. Am. Soc. Nephrol. 27(8 Aug), 2487–2494 (2016). https://doi.org/10.1681/ASN.2015060622

Article  CAS  PubMed  Google Scholar 

G.G. Rivelli, M.L. de Lima, M. Mazzali, Therapy for persistent hypercalcemic hyperparathyroidism post-renal transplant: cinacalcet versus parathyroidectomy. J. Bras. Nefrol. 42(3), 315–322 (2020). https://doi.org/10.1590/2175-8239-JBN-2019-0207

Article  PubMed  PubMed Central  Google Scholar 

S. Jung et al. Parathyroidectomy versus cinacalcet in the treatment of tertiary hyperparathyroidism after kidney transplantation: a retrospective study. Kidney Res. Clin. Pract. 41(4 Jul), 473–481 (2022). https://doi.org/10.23876/j.krcp.21.210

Article  PubMed  PubMed Central  Google Scholar 

H. Komaba et al. Parathyroidectomy vs cinacalcet among patients undergoing hemodialysis. J. Clin. Endocrinol. Metab. 107(7 Jun), 2016–2025 (2022). https://doi.org/10.1210/clinem/dgac142

Article  PubMed  Google Scholar 

L. Alvarado et al. Parathyroidectomy versus cinacalcet for the treatment of secondary hyperparathyroidism in hemodialysis patients. World J. Surg. 46(4 Apr), 813–819 (2022). https://doi.org/10.1007/s00268-022-06439-7

Article  PubMed  PubMed Central  Google Scholar 

M.A. Elhadedy, G. El-Kannishy, A.F. Refaie, H.A. Sheashaa, A. Halawa, Management of pre-renal transplant secondary hyperparathyroidism: parathyroidectomy versus cinacalcet. Drugs Context 12, (2023). https://doi.org/10.7573/dic.2022-11-5

B.M. Finnerty et al. Parathyroidectomy versus Cinacalcet in the management of tertiary hyperparathyroidism: surgery improves renal transplant allograft survival. Surgery 165(1 Jan), 129–134 (2019). https://doi.org/10.1016/j.surg.2018.04.090

Article  PubMed  Google Scholar 

R.R. Dulfer et al. Parathyroidectomy versus cinacalcet for tertiary hyperparathyroidism; a retrospective analysis. Langenbecks Arch. Surg. 404(1 Feb), 71–79 (2019). https://doi.org/10.1007/s00423-019-01755-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

P. Moreno et al. Long-term results of a randomized study comparing parathyroidectomy with cinacalcet for treating tertiary hyperparathyroidism. Clin. Transplant. 34(8 Aug), e13988 (2020). https://doi.org/10.1111/ctr.13988

Article  PubMed  Google Scholar 

R. Narayan et al. Parathyroidectomy versus cinacalcet hydrochloride-based medical therapy in the management of hyperparathyroidism in ESRD: a cost utility analysis. Am. J. Kidney Dis. 49(6 Jun), 801–813 (2007). https://doi.org/10.1053/j.ajkd.2007.03.009

Article  PubMed  Google Scholar 

R. Wang et al. Timing of parathyroidectomy after kidney transplantation: a cost-effectiveness analysis. Surgery 177(Oct), 108862 (2024). https://doi.org/10.1016/j.surg.2024.05.059

Article  PubMed  Google Scholar 

Z. Song et al. The effects of parathyroidectomy vs medical treatments for secondary hyperparathyroidism in patients undergoing dialysis: a meta-analysis. Endocr. Pract. 30(6 Jun), 569–576 (2024). https://doi.org/10.1016/j.eprac.2024.04.002

Article  PubMed  Google Scholar 

M. Chandran et al. The efficacy and safety of cinacalcet in primary hyperparathyroidism: a systematic review and meta-analysis of randomized controlled trials and cohort studies. Rev. Endocr. Metab. Disord. 23(3 Jun), 485–501 (2022). https://doi.org/10.1007/s11154-021-09694-6

Article  CAS  PubMed  Google Scholar 

N. Sekercioglu et al. Cinacalcet versus standard treatment for chronic kidney disease: a systematic review and meta-analysis. Ren. Fail. 38(6 Jul), 857–874 (2016). https://doi.org/10.3109/0886022X.2016.1172468

Article  CAS  PubMed  Google Scholar 

S.C. Palmer et al. Cinacalcet in patients with chronic kidney disease: a cumulative meta-analysis of randomized controlled trials. PLoS Med. 10(4), e1001436 (2013). https://doi.org/10.1371/journal.pmed.1001436

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif