Phosphate metabolism in primary hyperparathyroidism: a real-life long-term study

J.P. Bilezikian, L. Bandeira, A. Khan, N.E. Cusano, Hyperparathyroidism. Lancet 391(10116), 168–178 (2018). https://doi.org/10.1016/s0140-6736(17)31430-7

Article  CAS  PubMed  Google Scholar 

E. Castellano, R. Attanasio, A. Boriano, M. Pellegrino, G. Borretta, Serum phosphate: a neglected test in the clinical management of primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 107, 612–618 (2022). https://doi.org/10.1210/clinem/dgab676

Article  Google Scholar 

R. Cunningham, R. Biswas, M. Brazie, D. Steplock, S. Shenolikar, E.J. Weinman, Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. Am. J. Physiol. Ren. Physiol 296, F355–F361 (2009). https://doi.org/10.1152/ajprenal.90426.2008

Article  CAS  Google Scholar 

T. Kawata, Y. Imanishi, K. Kobayashi, T. Miki, A. Arnold, M. Inaba, Y. Nishizawa, Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism. J. Am. Soc. Nephrol. 18, 2683–2688 (2007). https://doi.org/10.1681/asn.2006070783

Article  CAS  PubMed  Google Scholar 

M. Peacock, Phosphate metabolism in health and disease. Calcif. Tissue Int. 108, 3–15 (2021). https://doi.org/10.1007/s00223-020-00686-3

Article  CAS  PubMed  Google Scholar 

O. Andrukhova, J. Bayer, C. Schüler, U. Zeitz, S.K. Murali, S. Ada, J.M. Alvarez-Pez, A. Smorodchenko, R.G. Erben, Klotho lacks an FGF23-independent role in mineral homeostasis. J. Bone Min. Res. 32, 2049–2061 (2017). https://doi.org/10.1002/jbmr.3195

Article  CAS  Google Scholar 

J.P Bilezikian, M.L Brandi, R Eastell, S.J Silverberg, R Udelsman, C Marcocci, J.T PottsJr, Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop. J. Clin. Endocrinol. Metab. 99, 3561–3569 (2014). https://doi.org/10.1210/jc.2014-1413.

Article  CAS  PubMed  PubMed Central  Google Scholar 

H. Yamashita, T. Yamashita, M. Miyamoto, T. Shigematsu, J.J. Kazama, T. Shimada, Y. Yamazaki, S. Fukumoto, M. Fukagaw, S. Noguchi, Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism. Eur. J. Endocrinol. 151, 55–60 (2004). https://doi.org/10.1530/eje.0.1510055

Article  CAS  PubMed  Google Scholar 

K. Kobayashi, Y. Imanishi, A. Miyauchi, N. Onoda, T. Kawata, H. Tahara, H. Goto, T. Miki, E. Ishimura, T. Sugimoto, T. Ishikawa, M. Inaba, Y. Nishizawa, Regulation of plasma fibroblast growth factor 23 by calcium in primary hyperparathyroidism. Eur. J. Endocrinol. 154, 93–99 (2006). https://doi.org/10.1530/eje.1.02053

Article  CAS  PubMed  Google Scholar 

J.E. Witteveen, A.H. van Lierop, S.E. Papapoulos, N.A. Hamdy, Increased circulating levels of FGF23: an adaptive response in primary hyperparathyroidism? Eur. J. Endocrinol. 166, 55–60 (2012). https://doi.org/10.1530/eje-11-0523

Article  CAS  PubMed  Google Scholar 

C. Cipriani, J. Pepe, L. Colangelo, V. Fassino, M. Occhiuto, P. Biondi, L. Nieddu, S. Minisola, Investigating subtle kidney injury in primary hyperparathyroidism by means of sensitive and specific biomarkers. Clin. Endocrinol. 91, 660–668 (2019). https://doi.org/10.1111/cen.14064

Article  CAS  Google Scholar 

P.J. Tebben, R.J. Singh, B.L. Clarke, R. Kumar, Fibroblast growth factor 23, parathyroid hormone, and 1alpha,25-dihydroxyvitamin D in surgically treated primary hyperparathyroidism. Mayo Clin. Proc. 79, 1508–1513 (2004). https://doi.org/10.4065/79.12.1508

Article  CAS  PubMed  Google Scholar 

I.L. Nilsson, S. Norenstedt, F. Granath, J. Zedenius, Y. Pernow, T.E. Larsson, FGF23, metabolic risk factors, and blood pressure in patients with primary hyperparathyroidism undergoing parathyroid adenomectomy. Surgery 159, 211–217 (2016). https://doi.org/10.1016/j.surg.2015.06.057

Article  PubMed  Google Scholar 

S.K. Bhadada, J. Ghosh, R. Pal, S. Mukherjee, Phosphate: an underrated component of primary hyperparathyroidism. Best. Pract. Res. Clin. Endocrinol. Metab. 38, 101837 (2024). https://doi.org/10.1016/j.beem.2023.101837

Article  CAS  PubMed  Google Scholar 

D. Rendina, T. Esposito, G. Mossetti, G. De Filippo, F. Gianfrancesco, A. Perfetti, S. Magliocca, P. Formisano, D. Prié, P. Strazzullo, A functional allelic variant of the FGF23 gene is associated with renal phosphate leak in calcium nephrolithiasis. J. Clin. Endocrinol. Metab. 97, 840–844 (2012). https://doi.org/10.1210/jc.2011-1528

Article  CAS  Google Scholar 

F.P. Cappuccio, P. Strazzullo, M. Mancini, Kidney stones and hypertension: population-based study of an independent clinical association. BMJ 300, 1234–1236 (1990). https://doi.org/10.1136/bmj.300.6734.1234

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Gonnelli, C. Caffarelli, S. Cappelli, S. Rossi, N. Giordano, R. Nuti, Gender-specific associations of appendicular muscle mass with BMD in elderly Italian subjects. Calcif. Tissue Int. 95, 340–348 (2014). https://doi.org/10.1007/s00223-014-9902-3

Article  CAS  PubMed  Google Scholar 

R.J. Walton, O.L. Bijvoet, Nomogram for derivation of renal threshold phosphate concentration. Lancet 306, 309–310 (1975). https://doi.org/10.1016/s0140-6736(75)92736-1

Article  Google Scholar 

J.A. Kanis, E.V. McCloskey, H. Johansson, A. Oden, L.J. Melton, N. Khaltaev, A reference standard for the description of osteoporosis. Bone 42, 467–475 (2008). https://doi.org/10.1016/j.bone.2007.11.001

Article  CAS  PubMed  Google Scholar 

S. Baim, N. Binkley, J.P. Bilezikian et al. Official positions of the international society for clinical densitometry and executive summary of the 2007 ISCD position development conference. J. Clin. Densitom. 11, 75–91 (2008). https://doi.org/10.1016/j.jocd.2007.12.007

Article  PubMed  Google Scholar 

G. Guglielmi, G.M. Giannatempo, B.A. Blunt, S. Grampp, C.C. Glüer, M. Cammisa, H.K. Genant, Spinal bone mineral density by quantitative CT in a normal Italian population. Eur. Radiol. 5, 269–275 (1995). https://doi.org/10.1007/BF00185311

Article  Google Scholar 

H.K. Genant, C.Y. Wu, C. van Knijk, M. Nevitt, Vertebral fracture assessment using a semi-quantitative technique. J. Bone Min. Res. 8, 1137–1148 (1993). https://doi.org/10.1002/jbmr.5650080915

Article  CAS  Google Scholar 

D. Prié, P. Ureña Torres, G. Friedlander, Fibroblast growth factor 23-Klotho: a new axis of phosphate balance control. Med. Sci. 25, 489–495 (2009). https://doi.org/10.1051/medsci/2009255489

Article  Google Scholar 

H. Nishi, T. Nii-Kono, S. Nakanishi, Y. Yamazaki, T. Yamashita, S. Fukumoto, K. Ikeda, A. Fujimori, M. Fukagawa, Intravenous calcitriol therapy increases serum concentrations of fibroblast growth factor-23 in dialysis patients with secondary hyperparathyroidism. Nephron Clin. Pract. 101, c94–c99 (2005). https://doi.org/10.1159/000086347

Article  CAS  PubMed  Google Scholar 

C. Su, L. Meng, S.Z. Trooskin, S.A. Shapses, Y. He, A. Al-Dayyeni, X. Wang, Serum klotho levels in primary hyperparathyroidism patients before and after parathyroidectomy. Endocrine 70, 421–425 (2020). https://doi.org/10.1007/s12020-020-02427-w

Article  CAS  PubMed  Google Scholar 

M. Sykała, P. Szumowski, M. Mojsak, S. Abdelrazek, Ł. Żukowski, D. Lipińska, I. Juchnicka, G. Kozłowska, M. Szelachowska, A. Krętowski, J. Myśliwiec, Assessment of clinical utility of assaying FGF-23, klotho protein, osteocalcin, NTX, and sclerostin in patients with primary hyperparathyroidism. J. Clin. Med. 10, 3089 (2021). https://doi.org/10.3390/jcm10143089

Article  CAS  PubMed  PubMed Central  Google Scholar 

F. De Lucia, S. Minisola, E. Romagnoli, J. Pepe, C. Cipriani, A. Scillitani, N. Parikh, D.S. Rao, Effect of gender and geographic location on the expression of primary hyperparathyroidism. J. Endocrinol. Invest. 36, 123–126 (2013). https://doi.org/10.3275/8455

Article  CAS  PubMed  Google Scholar 

E. Castellano, R. Attanasio, A. Boriano, M. Pellegrino, F. Garino, L. Gianotti, G. Borretta, Sex difference in the clinical presentation of primary hyperparathyroidism: influence of menopausal status. J. Clin. Endocrinol. Metab. 102, 4148–4152 (2017). https://doi.org/10.1210/jc.2017-01080

Article  PubMed  Google Scholar 

J. Wang, S. Shete, A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases. Am. J. Hum. Genet. 83, 53–63 (2008). https://doi.org/10.1016/j.ajhg.2008.06.010

Comments (0)

No login
gif