De A, Bhagat N, Mehta M, Taneja S, Duseja A. Metabolic dysfunction-associated steatotic liver disease (MASLD) definition is better than MAFLD criteria for lean patients with NAFLD. J Hepatol. 2024;80(2):e61–2. https://doi.org/10.1016/j.jhep.2023.07.031.

Article  Google Scholar 

Song SJ, Lai JC, Wong GL, Wong VW, Yip TC. Can we use old NAFLD data under the new MASLD definition? J Hepatol. 2024;80(2):e54–6. https://doi.org/10.1016/j.jhep.2023.07.021.

Article  MATH  Google Scholar 

Lonardo A, Mantovani A, Petta S, Carraro A, Byrne CD, Targher G. Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation. Nat Reviews Endocrinol. 2022;18(10):638–50. https://doi.org/10.1038/s41574-022-00711-5.

Article  Google Scholar 

Wei S, Wang L, Evans PC, Xu S. NAFLD and NASH: etiology, targets and emerging therapies. Drug Discovery Today. 2024;29(3):103910. https://doi.org/10.1016/j.drudis.2024.103910.

Article  Google Scholar 

Moodley N. Copeptin analysis in endocrine disorders. Front Endocrinol. 2023;14:1230045. https://doi.org/10.3389/fendo.2023.1230045.

Article  Google Scholar 

Radenković M, Xu Z, Editorial. Endothelial dysfunction in endocrine disorders. Front Endocrinol. 2023;14:1321072. https://doi.org/10.3389/fendo.2023.132107.

Article  Google Scholar 

Li L, Song Y, Shi Y, Sun L. Thyroid hormone Receptor-β agonists in NAFLD Therapy: possibilities and challenges. J Clin Endocrinol Metab. 2023;108(7):1602–13. https://doi.org/10.1210/clinem/dgad072.

Article  MATH  Google Scholar 

Eslam M, Sanyal AJ, George J. MAFLD: A Consensus-Driven proposed nomenclature for metabolic Associated fatty liver disease. Gastroenterology. 2020;158(7):1999–e20141. https://doi.org/10.1053/j.gastro.2019.11.312.

Article  MATH  Google Scholar 

Yao Z, Gong Y, Chen W, Shao S, Song Y, Guo H, et al. Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice. Nat Metabolism. 2023;5(10):1706–25. https://doi.org/10.1038/s42255-023-00896-7.

Article  Google Scholar 

Chakraborty S, Anand S, Coe S, Reh B, Bhandari RK. The PCOS-NAFLD multidisease phenotype occurred in Medaka Fish Four generations after the removal of Bisphenol a exposure. Environ Sci Technol. 2023;57(34):12602–19. https://doi.org/10.1021/acs.est.3c01922.

Article  Google Scholar 

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, et al. Strengthening the reporting of Observational studies in Epidemiology using mendelian randomization: the STROBE-MR Statement. JAMA. 2021;326(16):1614–21. https://doi.org/10.1001/jama.2021.18236.

Article  Google Scholar 

Pang Z, Chong J, Zhou G, de Lima Morais DA, Chang L, Barrette M, et al. MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res. 2021;49(W1):W388–96. https://doi.org/10.1093/nar/gkab382.

Article  Google Scholar 

Clemente MG, Mandato C, Poeta M, Vajro P. Pediatric non-alcoholic fatty liver disease: recent solutions, unresolved issues, and future research directions. World J Gastroenterol. 2016;22(36):8078–93. https://doi.org/10.3748/wjg.v22.i36.8078.

Article  Google Scholar 

Ballestri S, Nascimbeni F, Romagnoli D, Baldelli E, Targher G, Lonardo A. Type 2 diabetes in non-alcoholic fatty liver Disease and Hepatitis C Virus Infection–Liver: the Musketeer in the spotlight. Int J Mol Sci. 2016;17(3):355. https://doi.org/10.1038/s41575-019-0210-2.

Article  Google Scholar 

Sutti S, Albano E. Adaptive immunity: an emerging player in the progression of NAFLD. Nat Reviews Gastroenterol Hepatol. 2020;17(2):81–92. https://doi.org/10.1038/s41575-019-0210-2.

Article  MATH  Google Scholar 

Zhang J, Ma B, Wang Z, Chen Y, Li C, Dong Y. Extracellular vesicle therapy for obesity-induced NAFLD: a comprehensive review of current evidence. Cell Communication Signaling: CCS. 2024;22(1):18. https://doi.org/10.1186/s12964-023-01292-0.

Article  MATH  Google Scholar 

Fan JG, Kim SU, Wong VW. New trends on obesity and NAFLD in Asia. J Hepatol. 2017;67(4):862–73. https://doi.org/10.1016/j.jhep.2017.06.003.

Article  MATH  Google Scholar 

Jarvis H, Craig D, Barker R, Spiers G, Stow D, Anstee QM, et al. Metabolic risk factors and incident advanced liver disease in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of population-based observational studies. PLoS Med. 2020;17(4):e1003100. https://doi.org/10.1371/journal.pmed.100310.

Article  Google Scholar 

Heidari R, Niknahad H, Sadeghi A, Mohammadi H, Ghanbarinejad V, Ommati MM, et al. Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury. Biomed Pharmacotherapy = Biomedecine Pharmacotherapie. 2018;103:75–86. https://doi.org/10.1016/j.biopha.2018.04.010.

Article  Google Scholar 

Thomas DD, Corey C, Hickok J, Wang Y, Shiva S. Differential mitochondrial dinitrosyliron complex formation by Nitrite and nitric oxide. Redox Biol. 2018;15:277–83. https://doi.org/10.1016/j.redox.2017.12.007.

Article  Google Scholar 

Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, et al. Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in Nonalcoholic Steatohepatitis. Diabetes Care. 2018;41(6):1235–43. https://doi.org/.

Article  Google Scholar 

Huang YW, Lee CL, Yang SS, Fu SC, Chen YY, Wang TC, et al. Statins reduce the risk of cirrhosis and its decompensation in Chronic Hepatitis B patients: a Nationwide Cohort Study. Am J Gastroenterol. 2016;111(7):976–85. https://doi.org/.

Article  MATH  Google Scholar 

Peng KY, Watt MJ, Rensen S, Greve JW, Huynh K, Jayawardana KS, et al. Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression. J Lipid Res. 2018;59(10):1977–86. https://doi.org/.

Article  Google Scholar 

Bril F, Barb D, Portillo-Sanchez P, Biernacki D, Lomonaco R, Suman A, et al. Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease. Hepatology (Baltimore MD). 2017;65(4):1132–44. https://doi.org/.

Article  Google Scholar 

Stefan N, Fritsche A, Schick F, Häring HU. Phenotypes of prediabetes and stratification of cardiometabolic risk. Lancet Diabetes Endocrinol. 2016;4(9):789–98. https://doi.org/10.1016/S2213-8587(16)00082-6.

Article  Google Scholar 

Zhang J, Xu Q, Lai F, Chen N, Lin M, Liu Y, et al. Joint associations of metabolically healthy abdominal obesity and non-alcoholic fatty liver disease with prediabetes and diabetes in Chinese adults. BMJ open Diabetes Res care. 2021;9(1). https://doi.org/10.1136/bmjdrc-2021-002362.

So WY, Liu WN, Teo AKK, Rutter GA, Han W. Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis. Sci Transl Med. 2021;13(600). https://doi.org/10.1126/scitranslmed.abb1038.

Miyaji S, Ito T, Kitaiwa T, Nishizono K, Agake SI, Harata H, et al. N(2)-Acetylornithine deacetylase functions as a cys-gly dipeptidase in the cytosolic glutathione degradation pathway in Arabidopsis thaliana. Plant Journal: Cell Mol Biology. 2024;118(5):1603–18. https://doi.org/10.1111/tpj.16700.

Article  Google Scholar 

Liu Y, Tian H, Xu L, Zhou L, Wang J, Xu B, et al. Investigations of the kinetics and mechanism of reduction of a carboplatin pt(IV) Prodrug by the Major Small-Molecule reductants in Human plasma. Int J Mol Sci. 2019;20(22). https://doi.org/.

Pastore A, Alisi A, di Giovamberardino G, Crudele A, Ceccarelli S, Panera N, et al. Plasma levels of homocysteine and cysteine increased in pediatric NAFLD and strongly correlated with severity of liver damage. Int J Mol Sci. 2014;15(11):21202–14. https://doi.org/.

Article  Google Scholar 

Oz HS, Chen TS, Neuman M. Methionine deficiency and hepatic injury in a dietary steatohepatitis model. Dig Dis Sci. 2008;53(3):767–76. https://doi.org/10.1007/s10620-007-9900-7.

Article  MATH  Google Scholar 

Saba L, Ikeda N, Deidda M, Araki T, Molinari F, Meiburger KM, et al. Association of automated carotid IMT measurement and HbA1c in Japanese patients with coronary artery disease. Diabetes Res Clin Pract. 2013;100(3):348–53. https://doi.org/10.1016/j.diabres.2013.03.032.

Article  Google Scholar 

Luo S, Surapaneni A, Zheng Z, Rhee EP, Coresh J, Hung AM, et al. NAT8 variants, N-Acetylated amino acids, and progression of CKD. Clin J Am Soc Nephrology: CJASN. 2020;16(1):37–47. https://doi.org/10.2215/CJN.08600520.

Article  Google Scholar 

Razavi AC, Bazzano LA, He J, Fernandez C, Whelton SP, Krousel-Wood M, et al. Novel findings from a Metabolomics Study of Left ventricular diastolic function: the Bogalusa Heart Study. J Am Heart Association. 2020;9(3):e015118. https://doi.org/10.1161/JAHA.119.015118.

Article  Google Scholar 

Smith-Byrne K, Cerani A, Guida F, Zhou S, Agudo A, Aleksandrova K, et al. Circulating Isovalerylcarnitine and Lung Cancer Risk: evidence from mendelian randomization and prediagnostic blood measurements. Cancer Epidemiol Biomarkers Prevention: Publication Am Association Cancer Res Cosponsored Am Soc Prev Oncol. 2022;31(10):1966–74. https://doi.org/10.1158/1055-9965.EPI-21-1033.

Article  Google Scholar 

Gu Y, Jin Q, Hu J, Wang X, Yu W, Wang Z, et al. Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study. J Translational Med. 2023;21(1):357. https://doi.org/10.1186/s12967-023-04165-9.

Article  MATH  Google Scholar 

Hu ZC, Tian YH, Yang JL, Zhu YN, Zhou HY, Zheng YG, et al. Research progress of L-aspartate-α-decarboxylase and its isoenzyme in the β-alanine synthesis. World J Microbiol Biotechnol. 2022;39(2):42. https://doi.org/10.1007/s11274-022-03483-2.

Article  Google Scholar 

Grimaldi M, Marino C, Buonocore M, Santoro A, Sommella E, Merciai F, et al. Prenatal and early postnatal cerebral d-Aspartate depletion influences l-Amino acid pathways, bioenergetic processes, and Developmental Brain metabolism. J Proteome Res. 2021;20(1):727–39. https://doi.org/10.1021/acs.jproteome.0c00622.

Article