The dynamic evolution of lineage switch under CD19 CAR-T treatment in non-KMT2A rearranged B-ALL patients

Labanieh L, Mackall CL. CAR immune cells: design principles, resistance and the next generation. Nature. 2023;614:635–48.

Article  CAS  PubMed  Google Scholar 

Zhou T, Curry CV, Khanlari M, Shi M, Cui W, Peker D, et al. Genetics and pathologic landscape of lineage switch of acute leukemia during therapy. Blood Cancer J. 2024;14:19.

Article  PubMed  Google Scholar 

Duell J, Leipold AM, Appenzeller S, Fuhr V, Rauert-Wunderlich H, Da Via M, et al. Sequential antigen loss and branching evolution in lymphoma after CD19- and CD20-targeted T-cell-redirecting therapy. Blood. 2024;143:685–96.

Article  CAS  PubMed  Google Scholar 

Chen C, Yu W, Alikarami F, Qiu Q, Chen C-H, Flournoy J, et al. Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia. Blood. 2022;139:2198–211.

Article  CAS  PubMed  Google Scholar 

Tirtakusuma R, Szoltysek K, Milne P, Grinev VV, Ptasinska A, Chin PS, et al. Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia. Blood. 2022;140:1875–90.

Article  CAS  PubMed  Google Scholar 

Coorens THH, Collord G, Treger TD, Adams S, Mitchell E, Newman B, et al. Clonal origin of KMT2A wild-type lineage-switch leukemia following CAR-T cell and blinatumomab therapy. Nat Cancer. 2023;4:1095–101.

Article  CAS  PubMed  Google Scholar 

Lee BM, Summers C, Chisholm KM, Bohling SD, Leger KJ, Gardner R, et al. Plasticity of lineage switch in B-ALL allows for successful rechallenge with CD19-directed immunotherapy. Blood Adv. 2023;7:2825–30.

Article  PubMed  PubMed Central  Google Scholar 

Sportoletti P, Sorcini D, Falini B. BCOR gene alterations in hematologic diseases. Blood. 2021;138:2455–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao Q, Gearhart MD, Gery S, Shojaee S, Yang H, Sun H, et al. BCOR regulates myeloid cell proliferation and differentiation. Leukemia. 2016;30:1155–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schaefer EJ, Wang HC, Karp HQ, Meyer CA, Cejas P, Gearhart MD, et al. BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes. Blood Cancer Discov. 2022;3:116–35.

Article  PubMed  PubMed Central  Google Scholar 

Kelly MJ, So J, Rogers AJ, Gregory G, Li J, Zethoven M, et al. Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis. Nat Commun. 2019;10:1347.

Article  PubMed  PubMed Central  Google Scholar 

Oetjen KA, Lindblad KE, Goswami M, Gui G, Dagur PK, Lai C, et al. Human bone marrow assessment by single-cell RNA sequencing, mass cytometry, and flow cytometry. JCI Insight. 2018;3:e124928.

Article  PubMed  PubMed Central  Google Scholar 

Saygin C, Zhang P, Stauber J, Aldoss I, Sperling AS, Weeks LD, et al. Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis. Blood Cancer Discov. 2024;5:164–79.

Article  CAS  PubMed  Google Scholar 

Rabilloud T, Potier D, Pankaew S, Nozais M, Loosveld M, Payet-Bornet D. Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy. Nat Commun. 2021;12:865.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacoby E, Nguyen SM, Fountaine TJ, Welp K, Gryder B, Qin H, et al. CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Nat Commun. 2016;7:12320.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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