In vitro spectroscopic analysis of the chemical interaction between calcium hypochlorite and chlorhexidine

Neelakantan P, Vishwanath V, Taschieri S, Corbella S. Present status and future directions: minimally invasive root canal preparation and periradicular surgery. Int Endod J. 2022;55:845–71. https://doi.org/10.1111/iej.13750.

Article  PubMed  Google Scholar 

Tejada S, Baca P, Ferrer-Luque CM, Ruiz-Linares M, Valderrama MJ, Arias-Moliz MT. Influence of dentine debris and organic tissue on the properties of sodium hypochlorite solutions. Int Endod J. 2019;52:114–22. https://doi.org/10.1111/iej.12986.

Article  CAS  PubMed  Google Scholar 

Kuijper MCFM, Meisberger EW, Rijpkema AG, et al. Survival of molar teeth in need of complex endodontic treatment: influence of the endodontic treatment and quality of the restoration. J Dent. 2021;108: 103611. https://doi.org/10.1016/j.jdent.2021.103611.

Article  PubMed  Google Scholar 

Violich DR, Chandler NP. The smear layer in endodontics—a review. Int Endod J. 2010;43:2–15. https://doi.org/10.1111/j.1365-2591.2009.01627.x.

Article  CAS  PubMed  Google Scholar 

Ruksakiet K, Hanák L, Farkas N, Hegyi P, Sadaeng W, Czumbel LM, Sang-Ngoen T, Garami A, Mikó A, Varga G, Lohinai Z. Antimicrobial efficacy of chlorhexidine and sodium hypochlorite in root canal disinfection: a systematic review and meta-analysis of randomized controlled trials. J Endod. 2020;46(8):1032-1041.e7. https://doi.org/10.1016/j.joen.2020.05.002.

Article  PubMed  Google Scholar 

Zehnder M. Root canal irrigants. J Endod. 2006;32:389–98. https://doi.org/10.1016/j.joen.2005.09.014.

Article  PubMed  Google Scholar 

Gomes BPFA, Aveiro E, Kishen A. Irrigants and irrigation activation systems in endodontics. Braz Dent J. 2023;34:1–33. https://doi.org/10.1590/0103-6440202305577.

Article  PubMed  PubMed Central  Google Scholar 

Boutsioukis C, Arias-Moliz MT. Present status and future directions—irrigants and irrigation methods. Int Endod J. 2022;55:588–612. https://doi.org/10.1111/iej.13739.

Article  PubMed  PubMed Central  Google Scholar 

Rossi-fedele G, Dogramaci EJ, Guastalli AR, Steier L, Figueiredo JAP. Antagonistic interactions between sodium hypochlorite, chlorhexidine, EDTA and citric acid. J Endod. 2012;38:426–31. https://doi.org/10.1016/j.joen.2012.01.006.

Article  PubMed  Google Scholar 

Bueso V, Parikh N, Terlier T, Holland JN, Sarmast ND, Jeong JW. Comparative evaluation of intermediate solutions in prevention of brown precipitate formed from sodium hypochlorite and chlorhexidine gluconate. Clin Exp Dent Res. 2022;8:1591–7. https://doi.org/10.1002/cre2.654.

Article  PubMed  PubMed Central  Google Scholar 

Jeong JW, Sarmast ND, Terlier T, Hoeven R, Holland JN, Parikh N. Assessment of the cytotoxic effects and chemical composition of the insoluble precipitate formed from sodium hypochlorite and chlorhexidine gluconate. Int Endod J. 2021;54:1892–901. https://doi.org/10.1111/iej.13583.

Article  PubMed  Google Scholar 

Basrani BR, Manek S, Mathers D, Fillery E, Sodhi RN. Determination of 4-chloroaniline and its derivatives formed in the interaction of sodium hypochlorite and chlorhexidine by using gas chromatography. J Endod. 2010;36:312–4. https://doi.org/10.1016/j.joen.2009.10.031.

Article  PubMed  Google Scholar 

Basrani BR, Manek S, Sodhi RNS, Fillery E, Manzur A. Interaction between sodium hypochlorite and chlorhexidine gluconate. J Endod. 2007;33:966–9. https://doi.org/10.1016/j.joen.2007.04.001.

Article  PubMed  Google Scholar 

Drews D, Nguyen AD, Diederich A, Gernhardt CR. The interaction of two widely used endodontic irrigants, chlorhexidine and sodium hypochlorite, and its impact on the disinfection protocol during root canal treatment. Antibiotics (Basel). 2023;12:589. https://doi.org/10.3390/antibiotics12030589.

Article  CAS  PubMed  Google Scholar 

Homayouni H, Majd NM, Zohrehei H, Mosavari B, Adel M, Dajmar R, Homayouni A. The effect of root canal irrigation with combination of sodium hypo-chlorite and chlorhexidine gluconate on the sealing ability of obturation materials. Open Dent J. 2014;22:184–7. https://doi.org/10.2174/1874210601408010184.

Article  Google Scholar 

Prado M, Santos Junior HM, Rezende CM, Pinto AC, Faria RB, Simao RA, Gomes BPFA. Interactions between irrigants commonly used in endodontic practice: a chemical analysis. J Endod. 2013;39:505–10. https://doi.org/10.1016/j.joen.2012.11.050.

Article  PubMed  Google Scholar 

Thomas JE, Sem DS. An in vitro spectroscopic analysis to determine whether para-chloroaniline is produced from mixing sodium hypochlorite and chlorhexidine. J Endod. 2010;36(2):315–7. https://doi.org/10.1016/j.joen.2009.10.028.

Article  PubMed  Google Scholar 

Nowicki JB, Sem DS. An in vitro spectroscopic analysis to determine the chemical composition of the precipitate formed by mixing sodium hypochlorite and chlorhexidine. J Endod. 2011;37:983–8. https://doi.org/10.1016/j.joen.2011.03.033.

Article  PubMed  PubMed Central  Google Scholar 

Nicoletti MA, Siqueira EL, Bombana AC, De Oliveira GG. Shelf-life of a 2.5% sodium hypochlorite solution as determined by Arrhenius equation. Braz Dent J. 2009;20:27–31. https://doi.org/10.1590/S0103-64402009000100004.

Article  PubMed  Google Scholar 

Rutala WA, Weber DJ. Use of inorganic hypochlorite (bleach) in health care facilities. Clin Microbiol Rev. 1997;10:597–610. https://doi.org/10.1128/cmr.10.4.597.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossi-Fedele G, Guastalli AR, Doğramacı EJ, Steier L, De Figueiredo JA. Influence of pH changes on chlorine-containing endodontic irrigating solutions. Int Endod J. 2011;44:792–9. https://doi.org/10.1111/j.1365-2591.2011.01911.x.

Article  CAS  PubMed  Google Scholar 

De Paula KB, Carlotto IB, Marconi DF, Ferreira MBC, Grecca FS, Montagner F. Calcium hypochlorite solutions—an in vitro evaluation of antimicrobial action and pulp dissolution. Eur Endod J. 2019;4:15–20. https://doi.org/10.14744/eej.2018.64936.

Article  PubMed  PubMed Central  Google Scholar 

Dutta A, Saunders WP. Comparative evaluation of calcium hypochlorite and sodium hypochlorite on soft-tissue dissolution. J Endod. 2012;38:1395–8. https://doi.org/10.1016/j.joen.2012.06.020.

Article  PubMed  Google Scholar 

Cecchin D, Giaretta VS, Cadorin BG, Souza MA, Vidal CMP, Farina AP. Effect of synthetic and natural-derived novel endodontic irrigant solutions on mechanical properties of human dentin. J Mater Sci Mater Med. 2017;28:141. https://doi.org/10.1007/s10856-017-5960-1.

Article  CAS  PubMed  Google Scholar 

de Pellegrin SF, Pauletto G, Carlotto IB, Mendes ALG, Mello PA, Bier CAS. Interactions between calcium hypochlorite and irrigants commonly used in endodontic practice: a chemical analysis. J Endod. 2023;49:894–900. https://doi.org/10.1016/j.joen.2023.05.003.

Article  PubMed  Google Scholar 

Bunaciu AA, Aboul-Enein HY, Fleschin S. Application of Fourier transform infrared spectrophotometry in pharmaceutical drugs analysis. Appl Spectrosc Rev. 2010;45:206–19. https://doi.org/10.1080/00387011003601044.

Article  Google Scholar 

Leonardo NGS, Carlotto IB, Luisi SB, Kopper PMP, Grecca FS, Montagner F. Calcium hypochlorite solutions: evaluation of surface tension and effect of different storage conditions and time periods over pH and available chlorine content. J Endod. 2016;42:641–5. https://doi.org/10.1016/j.joen.2016.01.006.

Article  PubMed  Google Scholar 

Gomes BP, Vianna ME, Zaia AA, Almeida JF, Souza-Filho FJ, Ferraz CC. Chlorhexidine in endodontics. Braz Dent J. 2013;24:89–102. https://doi.org/10.1590/0103-6440201302188.

Article  PubMed  Google Scholar 

Salas H, Vieira GCS, Palomino I, Valero J, Pacheco-Yanes J, Campello AF, Pérez AR. Outcome of endodontic treatment with chlorhexidine gluconate as main irrigant: a case series. Aust Endod J. 2020;46:307–14. https://doi.org/10.1111/aej.12401.

Article  PubMed  Google Scholar 

Pauletto G, Carlotto IB, da Rosa LS, Daudt NF, Pereira GKR, Bier CAS. Effect of calcium hypochlorite and sodium thiosulfate on the bond strength to pulp chamber dentin: a laboratory investigation. Eur J Oral Sci. 2023;131: e12938. https://doi.org/10.1111/eos.12938.

Article  CAS 

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