Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res. 2012;49:35–43.

Article  CAS  PubMed  Google Scholar 

Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127:514–25.

Article  CAS  PubMed  Google Scholar 

Zhao R, Liang H, Clarke E, Jackson C, Xue M. Inflammation in Chronic Wounds. Int J Mol Sci. 2016;17:2085.

Article  PubMed  PubMed Central  Google Scholar 

Kidzeru EB, Lebeko M, Sharma JR, Nkengazong L, Adeola HA, Ndlovu H, et al. Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars. Exp Dermatol. 2023;32:570–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008;453:314–21.

Article  CAS  PubMed  Google Scholar 

Schuster R, Younesi F, Ezzo M, Hinz B. The Role of Myofibroblasts in Physiological and Pathological Tissue Repair. Cold Spring Harb Perspect Biol. 2023;15:a041231.

Article  CAS  PubMed  Google Scholar 

Hong YK, Chang YH, Lin YC, Chen B, Guevara BEK, Hsu CK. Inflammation in Wound Healing and Pathological Scarring. Adv Wound Care (New Rochelle). 2023;12:288–300.

Article  PubMed  Google Scholar 

Limandjaja GC, Niessen FB, Scheper RJ, Gibbs S. Hypertrophic scars and keloids: Overview of the evidence and practical guide for differentiating between these abnormal scars. Exp Dermatol. 2021;30:146–61.

Article  CAS  PubMed  Google Scholar 

Moulin V, Larochelle S, Langlois C, Thibault I, Lopez-Vallé CA, Roy M. Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors. J Cell Physiol. 2004;198:350–8.

Article  CAS  PubMed  Google Scholar 

Huang Y, Wang Y, Wang X, Lin L, Wang P, Sun J, et al. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Med Sci Monit. 2020;26:e920736.

CAS  PubMed  PubMed Central  Google Scholar 

Luo S, Benathan M, Raffoul W, Panizzon RG, Egloff DV. Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions. Plast Reconstr Surg. 2001;107:87–96.

Article  CAS  PubMed  Google Scholar 

Schmieder SJ, Ferrer-Bruker SJ. Hypertrophic Scarring. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.

Barone N, Safran T, Vorstenbosch J, Davison PG, Cugno S, Murphy AM. Current Advances in Hypertrophic Scar and Keloid Management. Semin Plast Surg. 2021;35:145–52.

Article  PubMed  PubMed Central  Google Scholar 

Mirza R, DiPietro LA, Koh TJ. Selective and specific macrophage ablation is detrimental to wound healing in mice. Am J Pathol. 2009;175:2454–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goren I, Allmann N, Yogev N, Schürmann C, Linke A, Holdener M, et al. A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol. 2009;175:132–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferguson MW, O’Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 2004;359:839–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahdavian Delavary B, van der Veer WM, van Egmond M, Niessen FB, Beelen RH. Macrophages in skin injury and repair. Immunobiology. 2011;216:753–62.

Article  PubMed  Google Scholar 

Kloc M, Ghobrial RM, Wosik J, Lewicka A, Lewicki S, Kubiak JZ. Macrophage functions in wound healing. J Tissue Eng Regen Med. 2019;13:99–109.

CAS  PubMed  Google Scholar 

Li M, Hou Q, Zhong L, Zhao Y, Fu X. Macrophage Related Chronic Inflammation in Non-Healing Wounds. Front Immunol. 2021;12: 681710.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8:958–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao X, Lu C, Miao Y, Ren J, Cai X. Role of macrophage polarisation in skin wound healing. Int Wound J. 2023;20:2551–62.

Article  PubMed  PubMed Central  Google Scholar 

Tang D, Kang R, Coyne CB, Zeh HJ, Lotze MT. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev. 2012;249:158–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Becker L, Liu NC, Averill MM, Yuan W, Pamir N, Peng Y, et al. Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS One. 2012;7:e33297.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takamiya M, Fujita S, Saigusa K, Aoki Y. Simultaneous detection of eight cytokines in human dermal wounds with a multiplex bead-based immunoassay for wound age estimation. Int J Legal Med. 2008;122:143–8.

Article  PubMed  Google Scholar 

Kotwal GJ, Chien S. Macrophage Differentiation in Normal and Accelerated Wound Healing. Results Probl Cell Differ. 2017;62:353–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003;3:23–35.

Article  CAS  PubMed  Google Scholar 

Han X, Hu J, Zhao W, Lu H, Dai J, He Q. Hexapeptide induces M2 macrophage polarization via the JAK1/STAT6 pathway to promote angiogenesis in bone repair. Exp Cell Res. 2022;413: 113064.

Article  CAS  PubMed  Google Scholar 

Laskin DL, Sunil VR, Gardner CR, Laskin JD. Macrophages and tissue injury: agents of defense or destruction? Annu Rev Pharmacol Toxicol. 2011;51:267–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Idriss HT, Naismith JH. TNF α and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 2000;50:184–95.

Article  CAS  PubMed  Google Scholar 

Parameswaran N, Patial S. Tumor necrosis factor-α signaling in macrophages. Crit Rev Eukaryot Gene Expr. 2010;20:87–103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma X. TNF-α and IL-12: a balancing act in macrophage functioning. Microbes Infect. 2001;3:121–9.

Article  CAS  PubMed  Google Scholar 

Chong DLW, Trinder S, Labelle M, Rodriguez-Justo M, Hughes S, Holmes AM, et al. Platelet-