Weidmann H, Heikaus L, Long AT, Naudin C, Schlüter H, Renné T The plasma contact system, a protease cascade at the nexus of inflammation, coagulation and immunity (2017). Biochim Biophys Acta Mol Cell Res 1864(11 Pt B):2118–2127
Renné T, Schmaier AH, Nickel KF, Blombäck M, Maas C (2012) In vivo roles of factor XII. Blood 120(22):4296–4303
Article PubMed PubMed Central Google Scholar
Didiasova M, Wujak L, Schaefer L, Wygrecka M (2018) Factor XII in coagulation, inflammation and beyond. Cell Signal 51:257–265
Article CAS PubMed Google Scholar
Davoine C, Bouckaert C, Fillet M, Pochet L (2020) Factor XII/XIIa inhibitors: their discovery, development, and potential indications. Eur J Med Chem 208:112753
Article CAS PubMed Google Scholar
Dementiev A, Silva A, Yee C, Li Z, Flavin MT, Sham H, Partridge JR (2018) Structures of human plasma β-factor XIIa cocrystallized with potent inhibitors. Blood Adv 2(5):549–558
Article CAS PubMed PubMed Central Google Scholar
Schmaier AH, Stavrou EX (2019) Factor XII - what’s important but not commonly thought about. Res Pract Thromb Haemost 3(4):599–606
Article CAS PubMed PubMed Central Google Scholar
Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer HU, Burfeind P, Renné C, Gailani D, Nieswandt B, Renné T (2006) Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med 203(3):513–518
Article CAS PubMed PubMed Central Google Scholar
Renné T, Pozgajová M, Grüner S, Schuh K, Pauer HU, Burfeind P, Gailani D, Nieswandt B (2005) Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med 202(2):271–281
Article PubMed PubMed Central Google Scholar
Renné T, Nieswandt B, Gailani D (2006) The intrinsic pathway of coagulation is essential for thrombus stability in mice. Blood Cells Mol Dis 36(2):148–151
Kuijpers MJ, van der Meijden PE, Feijge MA, Mattheij NJ, May F, Govers-Riemslag J, Meijers JC, Heemskerk JW, Renné T, Cosemans JM (2014) Factor XII regulates the pathological process of thrombus formation on ruptured plaques. Arterioscler Thromb Vasc Biol 34(8):1674–1680
Article CAS PubMed Google Scholar
Renné T, Stavrou EX (2019) Roles of factor XII in Innate Immunity. Front Immunol 10:2011
Article PubMed PubMed Central Google Scholar
Maas C, Renné T (2018) Coagulation factor XII in thrombosis and inflammation. Blood 131(17):1903–1909
Article CAS PubMed Google Scholar
Xu Y, Cai TQ, Castriota G, Zhou Y, Hoos L, Jochnowitz N, Loewrigkeit C, Cook JA, Wickham A, Metzger JM, Ogletree ML, Seiffert DA, Chen Z (2014) Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit. Thromb Haemost 111(4):694–704
Article CAS PubMed Google Scholar
Barbieri CM, Wang X, Wu W, Zhou X, Ogawa AM, O’Neill K, Chu D, Castriota G, Seiffert DA, Gutstein DE, Chen Z (2017) Factor XIIa as a Novel Target for thrombosis: Target Engagement requirement and efficacy in a rabbit model of Microembolic signals. J Pharmacol Exp Ther 360(3):466–475
Article CAS PubMed Google Scholar
Yau JW, Liao P, Fredenburgh JC, Stafford AR, Revenko AS, Monia BP, Weitz JI (2014) Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits. Blood 123(13):2102–2107
Article CAS PubMed Google Scholar
Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T (2014) A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk. Sci Transl Med 6(222):222ra17
Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun MF, McCarty OJ, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, Gailani D (2014) Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood 123(11):1739–1746
Article CAS PubMed PubMed Central Google Scholar
Wilbs J, Kong XD, Middendorp SJ, Prince R, Cooke A, Demarest CT, Abdelhafez MM, Roberts K, Umei N, Gonschorek P, Lamers C, Deyle K, Rieben R, Cook KE, Angelillo-Scherrer A, Heinis C (2020) Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs. Nat Commun 11(1):3890
Article PubMed PubMed Central Google Scholar
Kalinin DV (2021) Factor XII(a) inhibitors: a review of the patent literature. Expert Opin Ther Pat 31(12):1155–1176
Article CAS PubMed Google Scholar
Kohs TCL, Lorentz CU, Johnson J, Puy C, Olson SR, Shatzel JJ, Gailani D, Hinds MT, Tucker EI, Gruber A, McCarty OJT, Wallisch M (2020) Development of coagulation factor XII antibodies for inhibiting vascular device-related thrombosis. Cell Mol Bioeng 14(2):161–175
Article PubMed PubMed Central Google Scholar
Kenne E, Nickel KF, Long AT, Fuchs TA, Stavrou EX, Stahl FR, Renné T (2015) Factor XII: a novel target for safe prevention of thrombosis and inflammation. J Intern Med 278(6):571–585
Article CAS PubMed Google Scholar
Goel A, Tathireddy H, Wang SH, Vu HH, Puy C, Hinds MT, Zonies D, McCarty OJT, Shatzel JJ (2023) Targeting the contact pathway of Coagulation for the Prevention and Management of Medical device-Associated thrombosis. Semin Thromb Hemost. https://doi.org/10.1055/s-0043-57011
Howl J, Payne SJ (2003) Bradykinin receptors as a therapeutic target. Expert Opin Ther Targets 7(2):277–285
Article CAS PubMed Google Scholar
Longhurst HJ, Bork K (2019) Hereditary Angioedema: an update on causes, manifestations and treatment. Br J Hosp Med (Lond) 80(7):391–398
Bender L, Weidmann H, Rose-John S, Renné T, Long AT (2017) Factor XII-Driven inflammatory reactions with implications for Anaphylaxis. Front Immunol 8:1115
Article PubMed PubMed Central Google Scholar
Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG (2016) Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun 7:11626
Article PubMed PubMed Central Google Scholar
Chen ZL, Revenko AS, Singh P, MacLeod AR, Norris EH, Strickland S (2017) Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice. Blood 129(18):2547–2556
Article CAS PubMed PubMed Central Google Scholar
Raghunathan V, Zilberman-Rudenko J, Olson SR, Lupu F, McCarty OJT, Shatzel JJ (2019) The contact pathway and sepsis. Res Pract Thromb Haemost 3(3):331–339. https://doi.org/10.1002/rth2.12217
Article PubMed PubMed Central Google Scholar
Al-Horani RA, Afosah DK, Mottamal M (2023) Triazol-1-yl Benzamides promote anticoagulant activity via inhibition of factor XIIa. Cardiovasc Hematol Agents Med Chem 21(2):108–119
Article CAS PubMed PubMed Central Google Scholar
Woodland MD, Thompson A, Lipford A, Goyal N, Schexnaildre JC, Mottamal M, Afosah DK, Al-Horani RA (2024) New Triazole-based potent inhibitors of human factor XIIa as anticoagulants. ACS Omega 9(9):10694–10708
Comments (0)