An outbreak of blaKPC−4- and blaVIM−1-producing Klebsiella pneumoniae and Klebsiella variicola at a single hospital in South Korea

Park JW, Lee E, Lee SJ, Lee H. Status of carbapenemase-producing Enterobacteriaceae incidences in Korea, 2015–2016. Public Health Wkly Rep. 2017;10:1243–7.

Google Scholar 

Lim J, Sim J, Lee H, Hyun J, Lee S, Park S. Characteristics of Carbapenem-resistant Enterobacteriaceae (CRE) in the Republic of Korea, 2022. Public Health Wkly Rep. 2024;17:115–27.

Google Scholar 

Papagiannitsis CC, Dolejska M, Izdebski R, Giakkoupi P, Skalova A, Chudejova K, et al. Characterisation of IncA/C2 plasmids carrying an In416-like integron with the blaVIM-19 gene from Klebsiella pneumoniae ST383 of Greek origin. Int J Antimicrob Agents. 2016;47:158–62.

Article  PubMed  CAS  Google Scholar 

Park SH, Yi Y, Suh W, Ji SK, Han E, Shin S. The impact of enhanced screening for carbapenemase-producing enterobacterales in an acute care hospital in South Korea. Antimicrob Resist Infect Control. 2023;12:62.

Article  PubMed  PubMed Central  Google Scholar 

Thomson GK, Snyder JW, McElheny CL, Thomson KS, Doi Y. Coproduction of KPC-18 and VIM-1 carbapenemases by Enterobacter cloacae: implications for newer beta-lactam-beta-lactamase inhibitor combinations. J Clin Microbiol. 2016;54:791–4.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Villa J, Arana DM, Viedma E, Perez-Montarelo D, Chaves F. Characterization of mobile genetic elements carrying VIM-1 and KPC-2 carbapenemases in Citrobacter freundii isolates in Madrid. Int J Med Microbiol. 2017;307:340–5.

Article  PubMed  CAS  Google Scholar 

Protonotariou E, Poulou A, Politi L, Sgouropoulos I, Metallidis S, Kachrimanidou M, et al. Hospital outbreak due to a Klebsiella pneumoniae ST147 clonal strain co-producing KPC-2 and VIM-1 carbapenemases in a tertiary teaching hospital in Northern Greece. Int J Antimicrob Agents. 2018;52:331–7.

Article  PubMed  CAS  Google Scholar 

Steinmann J, Kaase M, Gatermann S, Popp W, Steinmann E, Damman M et al. Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011. Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2011;16.

Poirel L, Walsh TR, Cuvillier V, Nordmann P. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis. 2011;70:119–23.

Article  PubMed  CAS  Google Scholar 

Prjibelski A, Antipov D, Meleshko D, Lapidus A, Korobeynikov A. Using SPAdes De Novo Assembler. Curr Protoc Bioinf. 2020;70:e102.

Article  CAS  Google Scholar 

Seemann T. Prokka: rapid prokaryotic genome annotation. Bioinformatics. 2014;30:2068–9.

Article  PubMed  CAS  Google Scholar 

Lam MMC, Wick RR, Watts SC, Cerdeira LT, Wyres KL, Holt KE. A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex. Nat Commun. 2021;12:4188.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Alcock BP, Huynh W, Chalil R, Smith KW, Raphenya AR, Wlodarski MA, et al. CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database. Nucleic Acids Res. 2023;51:D690–9.

Article  PubMed  CAS  Google Scholar 

Neron B, Littner E, Haudiquet M, Perrin A, Cury J, Rocha EPC. IntegronFinder 2.0: identification and analysis of integrons across Bacteria, with a Focus on Antibiotic Resistance in Klebsiella. Microorganisms. 2022;10.

Johansson MHK, Bortolaia V, Tansirichaiya S, Aarestrup FM, Roberts AP, Petersen TN. Detection of mobile genetic elements associated with antibiotic resistance in Salmonella enterica using a newly developed web tool: MobileElementFinder. J Antimicrob Chemother. 2021;76:101–9.

Article  PubMed  CAS  Google Scholar 

Carattoli A, Zankari E, Garcia-Fernandez A, Voldby Larsen M, Lund O, Villa L, et al. In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing. Antimicrob Agents Chemother. 2014;58:3895–903.

Article  PubMed  PubMed Central  Google Scholar 

Tian D, Wang M, Zhou Y, Hu D, Ou HY, Jiang X. Genetic diversity and evolution of the virulence plasmids encoding aerobactin and salmochelin in Klebsiella pneumoniae. Virulence. 2021;12:1323–33.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Robertson J, Nash JHE. MOB-suite: software tools for clustering, reconstruction and typing of plasmids from draft assemblies. Microb Genom. 2018;4.

Evans D, Sundermann A, Griffith M, Rangachar Srinivasa V, Mustapha M, Chen J, et al. Empirically derived sequence similarity thresholds to study the genomic epidemiology of plasmids shared among healthcare-associated bacterial pathogens. EBioMedicine. 2023;93:104681.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Grant JR, Enns E, Marinier E, Mandal A, Herman EK, Chen CY, et al. Proksee: in-depth characterization and visualization of bacterial genomes. Nucleic Acids Res. 2023;51:W484–92.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stamatakis A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics. 2014;30:1312–3.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Partridge SR, Kwong SM, Firth N, Jensen SO. Mobile Genetic Elements Associated with Antimicrobial Resistance. Clin Microbiol Rev. 2018;31.

Tato M, Coque TM, Baquero F, Canton R. Dispersal of carbapenemase blaVIM-1 gene associated with different Tn402 variants, mercury transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010;54:320–7.

Article  PubMed  CAS  Google Scholar 

Cuzon G, Naas T, Nordmann P. Functional characterization of Tn4401, a Tn3-based transposon involved in blaKPC gene mobilization. Antimicrob Agents Chemother. 2011;55:5370–3.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bryant KA, Van Schooneveld TC, Thapa I, Bastola D, Williams LO, Safranek TJ, et al. KPC-4 is encoded within a truncated Tn4401 in an IncL/M plasmid, pNE1280, isolated from Enterobacter cloacae and Serratia marcescens. Antimicrob Agents Chemother. 2013;57:37–41.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yu L, Wang D, Li P, Cai Y, Zhang X, Luo X, et al. Epidemiology, molecular characterization, and drug resistance of IncHI5 plasmids from Enterobacteriaceae. Int Microbiol. 2023;26:371–8.

Article  PubMed  CAS  Google Scholar 

Liang Q, Jiang X, Hu L, Yin Z, Gao B, Zhao Y, et al. Sequencing and Genomic Diversity Analysis of IncHI5 plasmids. Front Microbiol. 2018;9:3318.

Article  PubMed  Google Scholar 

Yuan PB, Dai LT, Zhang QK, Zhong YX, Liu WT, Yang L, Chen DQ. Global emergence of double and multi-carbapenemase producing organisms: epidemiology, clinical significance, and evolutionary benefits on antimicrobial resistance and virulence. Microbiol Spectr. 2024;12:e0000824.

Article  PubMed  Google Scholar 

Lasarte-Monterrubio C, Guijarro-Sanchez P, Vazquez-Ucha JC, Alonso-Garcia I, Alvarez-Fraga L, Outeda M, et al. Antimicrobial activity of Cefiderocol against the carbapenemase-producing Enterobacter cloacae complex and characterization of reduced susceptibility Associated with Metallo-beta-lactamase VIM-1. Antimicrob Agents Chemother. 2023;67:e0150522.

Article  PubMed  Google Scholar 

Porres-Osante N, Azcona-Gutierrez JM, Rojo-Bezares B, Undabeitia E, Torres C, Saenz Y. Emergence of a multiresistant KPC-3 and VIM-1 carbapenemase-producing Escherichia coli strain in Spain. J Antimicrob Chemother. 2014;69:1792–5.

Article  PubMed  CAS  Google Scholar 

Perilli M, Bottoni C, Grimaldi A, Segatore B, Celenza G, Mariani M, et al. Carbapenem-resistant Klebsiella pneumoniae harbouring blaKPC-3 and blaVIM-2 from central Italy. Diagn Microbiol Infect Dis. 2013;75:218–21.

Article  PubMed  CAS  Google Scholar 

Castanheira M, Deshpande LM, Mills JC, Jones RN, Soave R, Jenkins SG, Schuetz AN. Klebsiella pneumoniae isolate from a New York City Hospital Belonging to sequence type 258 and carrying blaKPC-2 and blaVIM-4. Antimicrob Agents Chemother. 2016;60:1924–7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Decraene V, Phan HTT, George R, Wyllie DH, Akinremi O, Aiken Z et al. A large, refractory nosocomial outbreak of Klebsiella pneumoniae carbapenemase-producing Escherichia coli demonstrates Carbapenemase Gene outbreaks Involving Sink sites require novel approaches to infection control. Antimicrob Agents Chemother. 2018;62.

Weingarten RA, Johnson RC, Conlan S, Ramsburg AM, Dekker JP, Lau AF et al. Genomic Analysis of Hospital Plumbing reveals Diverse Reservoir of bacterial plasmids conferring Carbapenem Resistance. mBio. 2018;9.

Poirel L, Jayol A, Bontron S, Villegas MV, Ozdamar M, Turkoglu S, Nordmann P. The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae. J Antimicrob Chemother. 2015;70:75–80.

Article  PubMed 

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