Quality of IVM ovarian tissue oocytes: impact of clinical, demographic, and laboratory factors

Prasath EB, Chan ML, Wong WH, Lim CJ, Tharmalingam MD, Hendricks M, et al. First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient. Hum Reprod Hum Reprod. 2014;29:276–8.

Article  CAS  PubMed  Google Scholar 

Uzelac PS, Delaney AA, Christensen GL, Bohler HCL, Nakajima ST. Live birth following in vitro maturation of oocytes retrieved from extracorporeal ovarian tissue aspiration and embryo cryopreservation for 5 years. Fertil Steril. 2015;104:1258–60.

Article  PubMed  Google Scholar 

Segers I, Bardhi E, Mateizel I, Van Moer E, Schots R, Verheyen G, et al. Live births following fertility preservation using in-vitro maturation of ovarian tissue oocytes. Hum Reprod. 2020;35(9):2026–36.

Article  PubMed  Google Scholar 

Chen S, Du H, Liu J, Liu H, Li L, He Y. Live birth rate and neonatal outcomes of different quantities and qualities of frozen transferred blastocyst in patients requiring whole embryo freezing stratified by age. BMC Pregnancy Childbirth. 2020;20(1):655.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Awadalla M, Kim A, Vestal N, Ho J, Bendikson K. Effect of age and embryo morphology on live birth rate after transfer of unbiopsied blastocysts. JBRA Assist Reprod. 2021;25:373–82.

PubMed  PubMed Central  Google Scholar 

Zou H, Kemper JM, Hammond ER, Xu F, Liu G, Xue L, et al. Blastocyst quality and reproductive and perinatal outcomes: a multinational multicentre observational study. Hum Reprod Oxf Engl. 2023;38:2391–9.

Article  Google Scholar 

Meng F, Goldsammler M, Wantman E, Buyuk E, Jindal SK. Live birth rate from euploid blastocysts is not associated with infertility etiology or oocyte source following frozen-thawed embryo transfer (FET): analysis of 4148 cycles reported to SART CORS. J Assist Reprod Genet. 2021;38:185–92.

Article  CAS  PubMed  Google Scholar 

Kasaven LS, Marcus D, Theodorou E, Jones BP, Saso S, Naja R, et al. Systematic review and meta-analysis: does pre-implantation genetic testing for aneuploidy at the blastocyst stage improve live birth rate? J Assist Reprod Genet. 2023;40:2297–316.

Article  PubMed  PubMed Central  Google Scholar 

Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R, et al. Live birth with or without preimplantation genetic testing for aneuploidy. N Engl J Med. 2021;385:2047–58.

Article  CAS  PubMed  Google Scholar 

Sanders KD, Silvestri G, Gordon T, Griffin DK. Analysis of IVF live birth outcomes with and without preimplantation genetic testing for aneuploidy (PGT-A): UK Human Fertilisation and Embryology Authority data collection 2016–2018. J Assist Reprod Genet. 2021;38:3277–85.

Article  PubMed  PubMed Central  Google Scholar 

Whitney JB, Schiewe MC, Anderson RE. Single center validation of routine blastocyst biopsy implementation. J Assist Reprod Genet. 2016;33:1507–13.

Article  PubMed  PubMed Central  Google Scholar 

Balaban B, Urman B. Effect of oocyte morphology on embryo development and implantation. Reprod Biomed Online. 2006;12:608–15.

Article  PubMed  Google Scholar 

Rienzi L, Ubaldi F, Iacobelli M, Romano S, Minasi MG, Ferrero S, et al. Significance of morphological attributes of the early embryo. Reprod Biomed Online. 2005;10:669–81.

Article  PubMed  Google Scholar 

Rienzi L, Ubaldi FM, Iacobelli M, Minasi MG, Romano S, Ferrero S, et al. Significance of metaphase II human oocyte morphology on ICSI outcome. Fertil Steril. 2008;90:1692–700.

Article  PubMed  Google Scholar 

Ebner T, Moser M, Sommergruber M, Gaiswinkler U, Shebl O, Jesacher K, et al. Occurrence and developmental consequences of vacuoles throughout preimplantation development. Fertil Steril. 2005;83:1635–40.

Article  PubMed  Google Scholar 

Chamayou S, Ragolia C, Alecci C, Storaci G, Maglia E, Russo E, et al. Meiotic spindle presence and oocyte morphology do not predict clinical ICSI outcomes: a study of 967 transferred embryos. Reprod Biomed Online. 2006;13:661–7.

Article  CAS  PubMed  Google Scholar 

Mateizel I, Van Landuyt L, Tournaye H, Verheyen G. Deliveries of normal healthy babies from embryos originating from oocytes showing the presence of smooth endoplasmic reticulum aggregates. Hum Reprod Oxf Engl. 2013;28:2111–7.

Article  CAS  Google Scholar 

Otsuki J, Nagai Y, Chiba K. Lipofuscin bodies in human oocytes as an indicator of oocyte quality. J Assist Reprod Genet. 2007;24:263–70.

Article  PubMed  PubMed Central  Google Scholar 

de Cássia S Figueira R, de Almeida Ferreira Braga DP, Semião-Francisco L, Madaschi C, Iaconelli A, Borges E. Metaphase II human oocyte morphology: contributing factors and effects on fertilization potential and embryo developmental ability in ICSI cycles. Fertil Steril. 2010;94:1115–7.

Ten J, Mendiola J, Vioque J, de Juan J, Bernabeu R. Donor oocyte dysmorphisms and their influence on fertilization and embryo quality. Reprod Biomed Online. 2007;14:40–8.

Article  PubMed  Google Scholar 

Setti AS, Figueira RCS, Braga DPAF, Colturato SS, Iaconelli A, Borges E. Relationship between oocyte abnormal morphology and intracytoplasmic sperm injection outcomes: a meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2011;159:364–70.

Article  PubMed  Google Scholar 

Braga DPAF, Setti AS, Figueira R de CS, Machado RB, Iaconelli A, Borges E. Influence of oocyte dysmorphisms on blastocyst formation and quality. Fertil Steril. 2013;100:748–54.

Sá R, Cunha M, Silva J, Luís A, Oliveira C, Teixeira da Silva J, et al. Ultrastructure of tubular smooth endoplasmic reticulum aggregates in human metaphase II oocytes and clinical implications. Fertil Steril. 2011;96:143–149.e7.

Otsuki J, Okada A, Morimoto K, Nagai Y, Kubo H. The relationship between pregnancy outcome and smooth endoplasmic reticulum clusters in MII human oocytes. Hum Reprod Oxf Engl. 2004;19:1591–7.

Article  CAS  Google Scholar 

Massarotti C, Stigliani S, Ramone A, Bovis F, Sozzi F, Remorgida V, et al. Occurrence of smooth endoplasmic reticulum aggregates in metaphase II oocytes: relationship with stimulation protocols and outcome of ICSI and IVF cycles. Hum Reprod Oxf Engl. 2021;36:907–17.

Article  Google Scholar 

Otsuki J, Iwasaki T, Katada Y, Tsutsumi Y, Tsuji Y, Furuhashi K, et al. A higher incidence of cleavage failure in oocytes containing smooth endoplasmic reticulum clusters. J Assist Reprod Genet. 2018;35:899–905.

Article  PubMed  PubMed Central  Google Scholar 

Meriano JS, Alexis J, Visram-Zaver S, Cruz M, Casper RF. Tracking of oocyte dysmorphisms for ICSI patients may prove relevant to the outcome in subsequent patient cycles. Hum Reprod. 2001;16(10):2118–23.

Article  CAS  PubMed  Google Scholar 

Ebner T, Moser M, Shebl O, Sommerguber M, Tews G. Prognosis of oocytes showing aggregation of smooth endoplasmic reticulum. Reprod Biomed Online. 2008;16:113–8.

Article  PubMed  Google Scholar 

Van Blerkom J. Mitochondrial function in the human oocyte and embryo and their role in developmental competence. Mitochondrion. 2011;11:797–813.

Article  PubMed  Google Scholar 

Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod Oxf Engl. 2011;26:1270–83.

Balaban B, Ata B, Isiklar A, Yakin K, Urman B. Severe cytoplasmic abnormalities of the oocyte decrease cryosurvival and subsequent embryonic development of cryopreserved embryos. Hum Reprod Oxf Engl. 2008;23:1778–85.

Article  CAS  Google Scholar 

Ebner T, Moser M, Tews G. Is oocyte morphology prognostic of embryo developmental potential after ICSI? Reprod Biomed Online. 2006;12:507–12.

Article  PubMed  Google Scholar 

Ashrafi M, Karimian L, Eftekhari-Yazdi P, Hasani F, Arabipoor A, Bahmanabadi A, et al. Effect of oocyte dysmorphisms on intracytoplasmic sperm injection cycle outcomes in normal ovarian responders. J Obstet Gynaecol Res. 2015;41:1912–20.

Article  CAS  PubMed  Google Scholar 

Faramarzi A, Khalili MA, Ashourzadeh S. Oocyte morphology and embryo morphokinetics in an intra-cytoplasmic sperm injection programme. Is there a relationship? Zygote Camb Engl. 2017;25:190–6.

Lazzaroni-Tealdi E, Barad DH, Albertini DF, Yu Y, Kushnir VA, Russell H, et al. Oocyte scoring enhances embryo-scoring in predicting pregnancy chances with IVF where it counts most. PLoS ONE. 2015;10:e0143632.

Article  PubMed  PubMed Central  Google Scholar 

Serhal PF, Ranieri DM, Kinis A, Marchant S, Davies M, Khadum IM. Oocyte morphology predicts outcome of intracytoplasmic sperm injection. Hum Reprod. 1997;12:1267–70.

Article  CAS  PubMed  Google Scholar 

Loutradis D, Drakakis P, Kallianidis K, Milingos S, Dendrinos S, Michalas S. Oocyte morphology correlates with embryo quality and pregnancy rate after intracytoplasmic sperm injection. Fertil Steril. 1999;72:240–4.

Comments (0)

No login
gif