Bass AS, Cartwright ME, Mahon C, Morrison R, Snyder R, McNamara P, Bradley P, Zhou YY, Hunter J (2009) Exploratory drug safety: a discovery strategy to reduce attrition in development. J Pharmacol Toxicol Methods 60:69–78. https://doi.org/10.1016/j.vascn.2009.04.194
Article PubMed CAS Google Scholar
Benjamin B, Barman TK, Chaira T, Paliwal JK (2010) Integration of physicochemical and pharmacokinetic parameters in lead optimization: a physiological pharmacokinetic model based approach. Curr Drug Discov Technol 7:143–153. https://doi.org/10.2174/157016310793180558
Article PubMed CAS Google Scholar
Berrin JG, McLauchlan WR, Needs P, Williamson G, Puigserver A, Kroon PA, Juge N (2002) Functional expression of human liver cytosolic β-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides. Eur J Biochem 269:249–258. https://doi.org/10.1046/j.0014-2956.2001.02641.x
Article PubMed CAS Google Scholar
Berrin JG, Czjzek M, Kroon PA, McLauchlan WR, Puigserver A, Williamson G, Juge N (2003) Substrate (aglycone) specificity of human cytosolic beta-glucosidase. Biochem J 373:41–48. https://doi.org/10.1042/BJ20021876
Article PubMed PubMed Central CAS Google Scholar
Bijsterbosch MK, Duursma AM, Bouma JM, Gruber M, Nieuwenhuis P (1981) Plasma clearance and endocytosis of mitochondrial malate dehydrogenase in the rat. Biochem J 200:115–121. https://doi.org/10.1042/bj2000115
Article PubMed PubMed Central CAS Google Scholar
Boersma MG, van der Woude H, Bogaards J, Boeren S, Vervoort J, Cnubben NH, van Iersel ML, van Bladeren PJ, Rietjens IM (2002) Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. Chem Res Toxicol 15:662–670. https://doi.org/10.1021/tx0101705
Article PubMed CAS Google Scholar
Chawla S, Ghosh S, Sihorkar V, Nellore R, Shantha-Kumar TR, Srinivas NR (2006) High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal permeability studies using timed wavelength detection. Biomed Chromatogr 20:349–357. https://doi.org/10.1002/bmc.570
Article PubMed CAS Google Scholar
Courts FL, Williamson G (2009) The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans. Mol Nutr Food Res 53:1104–1111. https://doi.org/10.1002/mnfr.200800569
Article PubMed CAS Google Scholar
Dai P, Luo F, Wang Y, Jiang H, Wang L, Zhang G, Zhu L, Hu M, Wang X, Lu L, Liu Z (2015a) Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes. Biopharm Drug Dispos 36:622–635. https://doi.org/10.1002/bdd.1989
Article PubMed CAS Google Scholar
Dai P, Zhu L, Luo F, Lu L, Li Q, Wang L, Wang Y, Wang X, Hu M, Liu Z (2015b) Triple recycling processes impact systemic and local bioavailability of orally administered flavonoids. AAPS J 17:723–736. https://doi.org/10.1208/s12248-015-9732-x
Article PubMed PubMed Central CAS Google Scholar
Damle B, LaBadle R, Crownover P, Glue P (2007) Pharmacokinetic interactions of efavirenz and voriconazole in healthy volunteers. Br J Clin Pharmacol 65:523530. https://doi.org/10.1111/j.1365-2125.2007.03085.x
Day AJ, Gee JM, DuPont MS, Johnson IT, Williamson G (2003) Absorption of quercetin-3-glucoside and quercetin-4’-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol 65:1199–1206. https://doi.org/10.1016/s0006-2952(03)00039-x
Article PubMed CAS Google Scholar
Du Y, Xi M, Li Y, Zheng R, Ding X, Li X, Zhang X, Wang L, Xing J, Hong B (2023) Tilianin improves lipid profile and alleviates atherosclerosis in ApoE-/- mice through up-regulation of SREBP2-mediated LDLR expression. Phytomedicine 109:154577. https://doi.org/10.1016/j.phymed.2022.154577
Article PubMed CAS Google Scholar
Estrada-Reyes R, López-Rubalcava C, Ferreyra-Cruz OA, Dorantes-Barrón AM, Heinze G, Moreno-Aguilar J, Martínez-Vázquez M (2014) Central nervous system effects and chemical composition of two subspecies of Agastache mexicana; an ethnomedicine of Mexico. J Ethnopharmacol 153:98–110. https://doi.org/10.1016/j.jep.2013.12.057
Article PubMed CAS Google Scholar
Flores-Flores A, Hernández-Abreu O, Rios MY, León-Rivera I, Aguilar-Guadarrama B, Castillo-España P, Perea-Arango I, Estrada-Soto S (2016) Vasorelaxant mode of action of dichloromethane-soluble extract from Agastache mexicana and its main bioactive compounds. Pharm Biol 54:2807–2813. https://doi.org/10.1080/13880209.2016.1184690
Article PubMed CAS Google Scholar
García-Díaz JA, Navarrete-Vázquez G, García-Jiménez S, Hidalgo-Figueroa S, Almanza-Pérez JC, Alarcón-Aguilar FJ, Gómez-Zamudio J, Cruz M, Ibarra-Barajas M, Estrada-Soto S (2016) Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats. Biomed Pharmacother 83:667–675. https://doi.org/10.1016/j.biopha.2016.07.023
Article PubMed CAS Google Scholar
González-Trujano ME, Ventura-Martínez R, Chávez M, Díaz-Reval I, Pellicer F (2012) Spasmolytic and antinociceptive activities of ursolic acid and acacetin identified in Agastache mexicana. Planta Med 78:793–796. https://doi.org/10.1055/s-0031-1298416
Article PubMed CAS Google Scholar
González-Trujano ME, Ponce-Muñoz H, Hidalgo-Figueroa S, Navarrete-Vázquez G, Estrada-Soto S (2015) Depressant effects of Agastache mexicana methanol extract and one of major metabolites tilianin. Asian Pac J Trop Med 8:185–190. https://doi.org/10.1016/S1995-7645(14)60312-6
Guo X, Cao W, Yao J, Yuan Y, Hong Y, Wang X, Xing J (2015) Cardioprotective effects of tilianin in rat myocardial ischemia-reperfusion injury. Mol Med Rep 11:2227–2233. https://doi.org/10.3892/mmr.2014.2954
Article PubMed CAS Google Scholar
Gupta SC, Sundaram C, Reuter S, Aggarwal BB (2010) Inhibiting NF-κB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta 1799:775–787. https://doi.org/10.1016/j.bbagrm.2010.05.004
Article PubMed PubMed Central CAS Google Scholar
Hartmann A, Krebber R, Daube G, Hartmann K (2008) Pharmacokinetics of pradofloxacin and doxycycline in serum, saliva, and tear fluid of cats after oral administration. J Vet Pharmacol Ther 31:87–94. https://doi.org/10.1111/j.1365-2885.2007.00932.x
Article PubMed CAS Google Scholar
Havsteen BH (2002) The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96:67–202. https://doi.org/10.1016/s0163-7258(02)00298-x
Article PubMed CAS Google Scholar
Hernández-Abreu O, Castillo-España P, León-Rivera I, Ibarra-Barajas M, Villalobos-Molina R, González-Christen J, Vergara-Galicia J, Estrada-Soto S (2009) Antihypertensive and vasorelaxant effects of tilianin isolated from Agastache mexicana are mediated by NO/cGMP path way and potassium channel opening. Biochem Pharmacol 78:54–61. https://doi.org/10.1016/j.bcp.2009.03.016
Article PubMed CAS Google Scholar
Hernández-Abreu O, Durán-Gómez L, Best-Brown R, Villalobos-Molina R, Rivera-Leyva JC, Estrada-Soto S (2011) Validated liquid chromatographic method and analysis of content of tilianin on several extracts obtained from Agastache mexicana and its correlation with vasorelaxant effect. J Ethnopharmacol 138:487–491. https://doi.org/10.1016/j.jep.2011.09.041
Article PubMed CAS Google Scholar
Hernández-Abreu O, Torres-Piedra M, García-Jiménez S, Ibarra-Barajas M, Villalobos-Molina R, Montes S, Rembao D, Estrada-Soto S (2013) Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana. J Ethnopharmacol 146:187–191. https://doi.org/10.1016/j.jep.2012.12.029
Article PubMed CAS Google Scholar
Hong JJ, Choi JH, Oh SR, Lee HK, Park JH, Lee KY, Kim JJ, Jeong TS, Oh GT (2001) Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa. FEBS Lett 495:142–147. https://doi.org/10.1016/s0014-5793(01)02379-1
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