Ozone infiltration as an adjunctive treatment to piezoelectric surgery in the management of medication-related osteonecrosis of the jaws: case series of 29 patients

Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O (2017) Interventions for managing medication-related osteonecrosis of the jaw. Cochrane Database Syst Rev 6:10 CD012432. https://doi.org/10.1002/14651858.CD012432.pub2. Update in: Cochrane Database Syst Rev Jul 12:7 CD012432, 2022.

Otto S, Pautke C, Van den Wyngaert T, Niepel D, Schiødt M (2018) Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases. Cancer Treat Rev 69:177–187. https://doi.org/10.1016/j.ctrv.2018.06.007

Article  PubMed  Google Scholar 

Campisi G, Mauceri R, Bertoldo F, Bettini G, Biasotto M, Colella G, Consolo U, Di Fede O, Favia G, Fusco V, Gabriele M, Lo Casto A, Lo Muzio L, Marcianò A, Mascitti M, Meleti M, Mignogna MD, Oteri G, Panzarella V, Romeo U, Santarelli A, Vescovi P, Marchetti C, Bedogni A (2020) Medication-related osteonecrosis of jaws (MRONJ) Prevention and diagnosis: Italian Consensus Update 2020. Int J Environ Res Public Health 18:175998. https://doi.org/10.3390/ijerph17165998

Article  Google Scholar 

Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, Zillikens MC, Body JJ (2022) Osteonecrosis of the Jaw and Antiresorptive agents in Benign and Malignant diseases: a critical Review Organized by the ECTS. J Clin Endocrinol Metab 107:1441–1460. https://doi.org/10.1210/clinem/dgab888

Article  PubMed  Google Scholar 

Govaerts D, Piccart F, Ockerman A, Coropciuc R, Politis C, Jacobs R (2020) Adjuvant therapies for MRONJ: A systematic review. Bone 141:115676. https://doi.org/10.1016/j.bone.2020.115676

Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D (2022) American association of oral and maxillofacial surgeons’ position paper on medication-related osteonecrosis of the jaws – 2022 update. J Oral Maxillofac Surg 80:920–943.

Article  PubMed  Google Scholar 

Goker F, Grecchi E, Grecchi F, Francetti L, Del Fabbro M (2021) Treatment of medication-related osteonecrosis of the jaw (MRONJ). A systematic review. Eur Rev Med Pharmacol Sci 25:2662–2673. https://doi.org/10.26355/eurrev_202103_25430

Olate S, Uribe F, Martinez F, Almeida A, Unibazo A (2014) Osteonecrosis of the jaw in patient with denosumab therapy. Int J Clin Exp Med 7:3707–3709

PubMed  PubMed Central  Google Scholar 

Myoken Y, Fujita Y, Kawamoto K, Toratani S (2020) Osteonecrosis of the jaw in a metastatic lung cancer patient with bone metastases undergoing pembrolizumab + denosumab combination therapy: case report and literature review. Oral Oncol 111:104874. https://doi.org/10.1016/j.oraloncology.2020.104874

Article  PubMed  CAS  Google Scholar 

Santos-Silva AR, Belizário Rosa GA, Castro Júnior GD, Dias RB, Prado Ribeiro AC, Brandão TB (2013) Osteonecrosis of the mandible associated with bevacizumab therapy. Oral Surg Oral Med Oral Pathol Oral Radiol 115:e32–36. https://doi.org/10.1016/j.oooo.2013.02.001

Article  PubMed  Google Scholar 

Ramírez L, López-Pintor RM, Casañas E, Arriba LD, Hernández G (2015) New non-bisphosphonate drugs that produce osteonecrosis of the jaws. Oral Health Prev Dent 13:385–393. https://doi.org/10.3290/j.ohpd.a34055

Brunello A, Saia G, Bedogni A, Scaglione D, Basso U (2009) Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma. Bone 44:173–175

Article  PubMed  CAS  Google Scholar 

Del Fabbro M, Taschieri S, Goker F (2018) Platelet concentrates as an adjunctive therapy for medication-related osteonecrosis of the Jaw: a systematic review and meta-analysis. Int J Growth Factors Stem Cells Dent 1:48–57. https://doi.org/10.4103/GFSC.GFSC_19_18

Article  Google Scholar 

Goker F, Donati G, Grecchi F, Sparaco A, Ghezzi M, Rania V, Rossi CA, Del Fabbro M (2020) Treatment of BRONJ with ozone/oxygen therapy and debridement with piezoelectric surgery. Eur Rev Med Pharmacol Sci 24:9094 9103. https://doi.org/10.26355/eurrev_202009_22855

Otto S, Aljohani S, Fliefel R, Ecke S, Ristow O, Burian E, Troeltzsch M, Pautke C, Ehrenfeld M (2021) Infection as an important factor in medication-related osteonecrosis of the Jaw (MRONJ). Med (Kaunas) 57:463. https://doi.org/10.3390/medicina57050463

Article  Google Scholar 

Di Fede O, Del Gaizo C, Panzarella V, La Mantia G, Tozzo P, Di Grigoli A, Lo Casto A, Mauceri R, Campisi G (2022) Ozone infiltration for osteonecrosis of the Jaw Therapy: a Case Series. J Clin Med 11:5307. https://doi.org/10.3390/jcm11185307

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ripamonti CI, Cislaghi E, Mariani L, Maniezzo M (2011) Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study. Oral Oncol 47:185 190. https://doi.org/10.1016/j.oraloncology.2011.01.002

Agrillo A, Petrucci MT, Tedaldi M, Mustazza MC, Marino SM, Gallucci C, Iannetti G (2006) New therapeutic protocol in the treatment of avascular necrosis of the jaws. J Craniofac Surg 17:1080–1083. https://doi.org/10.1097/01.scs.0000249350.59096.d0

Agrillo A, Sassano P, Rinna C, Priore P, Iannetti G (2007) Ozone therapy in extractive surgery on patients treated with bisphosphonates. J Craniofac Surg 18:1068–1070. https://doi.org/10.1097/SCS.0b013e3181572609

Article  PubMed  Google Scholar 

Agrillo A, Filiaci F, Ramieri V, Riccardi E, Quarato D, Rinna C, Gennaro P, Cascino F, Mitro V, Ungari C (2012) Bisphosphonate-related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy. Eur Rev Med Pharmacol Sci 16:1741–1747

PubMed  CAS  Google Scholar 

Petrucci MT, Gallucci C, Agrillo A, Mustazza MC, Foà R (2007) Role of ozone therapy in the treatment of osteonecrosis of the jaws in multiple myeloma patients. Haematologica 92:1289–1290. https://doi.org/10.3324/haematol.11096

Bilge A, Öztürk Ö, Adali Y, Üstebay S (2018) Could ozone treatment be a promising alternative for osteomyelitis? An experimental study. Acta Ortop Bras 26:67–71. https://doi.org/10.1590/1413-785220182601179926

Article  PubMed  PubMed Central  Google Scholar 

Latini E, Curci ER, Massimiani A, Nusca SM, Santoboni F, Trischitta D, Vetrano M, Vulpiani MC (2019) Ultrasonography for oxygen-ozone therapy in musculoskeletal diseases. Med Gas Res 9:18–23. https://doi.org/10.4103/2045-9912.254638

Article  PubMed  PubMed Central  CAS  Google Scholar 

Seyam O, Smith NL, Reid I, Gandhi J, Jiang W, Khan SA (2018) Clinical utility of ozone therapy for musculoskeletal disorders. Med Gas Res 8:103–110. https://doi.org/10.4103/2045-9912.241075

Article  PubMed  PubMed Central  CAS  Google Scholar 

Raimondi A, Simeone N, Guzzo M, Maniezzo M, Collini P, Morosi C, Greco FG, Frezza AM, Casali PG, Stacchiotti S (2020) Rechallenge of denosumab in jaw osteonecrosis of patients with unresectable giant cell tumour of bone: a case series analysis and literature review. ESMO Open 5:e000663. https://doi.org/10.1136/esmoopen-2019-000663

Article  PubMed  PubMed Central  Google Scholar 

Carlson ER, Basile JD (2009) The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 67(5 Suppl):85–95. https://doi.org/10.1016/j.joms.2009.01.006

Akdeniz SS, Beyler E, Korkmaz Y, Yurtcu E, Ates U, Araz K, Sahin FI, Torun OY (2018) The effects of ozone application on genotoxic damage and wound healing in bisphosphonate-applied human gingival fibroblast cells. Clin Oral Investig 22:867–873. https://doi.org/10.1007/s00784-017-2163-6

Bocci V (1999) Biological and clinical effects of ozone. Has ozone therapy a future in medicine? Br J Biomed Sci 56:270–279

PubMed  CAS  Google Scholar 

Clavo B, Catalá L, Pérez JL, Rodríguez V, Robaina F (2004) Ozone therapy on cerebral blood flow: a preliminary report. Evid Based Complement Alternat Med 1:315–319. https://doi.org/10.1093/ecam/neh039

Article  PubMed  PubMed Central  Google Scholar 

Maluf G, Caldas RJ, Fregnani ER, da Silva Santos PS (2019) A rare case of bevacizumab-related osteonecrosis of the jaw associated with dental implants. Int J Implant Dent 5:34. https://doi.org/10.1186/s40729-019-0188-0

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif