Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance

Aaqil SI, Ochani S, Hasibuzzaman MA (2023) Recent outbreak of diphtheria in Pakistan; short communication. Ann Med Surg (Lond) 85(6):3243–3244. https://doi.org/10.1097/MS9.0000000000000832

Article  PubMed  Google Scholar 

Alikhan NF, Petty NK, Ben Zakour NL, Beatson SA (2011) BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics 12:402. https://doi.org/10.1186/1471-2164-12-402

Article  PubMed  PubMed Central  CAS  Google Scholar 

Antunes CA, Sanches dos Santos L, Hacker E, Köhler S, Bösl K, Ott L, de Md L, Hirata R Jr, Azevedo VA, Mattos-Guaraldi AL, Burkovski A (2015) Characterization of DIP0733, a multi-functional virulence factor of Corynebacterium diphtheriae. Microbiol (Reading) 161(Pt 3):639–647. https://doi.org/10.1099/mic.0.000020

Article  CAS  Google Scholar 

Araújo MRB, Ramos JN, de Sant’Anna O, Bokermann L, Santos S, Mattos-Guaraldi MBN, Azevedo AL, Prates V, Rodrigues FD, Aburjaile DLN, Sacchi FF, Campos CT, Alvim KR, Vieira LB, Camargo VV, Dos Santos CH (2023) Phenotypic and molecular characterization and complete genome sequence of a Corynebacterium diphtheriae strain isolated from cutaneous infection in an immunized individual. Braz J Microbiol 54(3):1325–1334. https://doi.org/10.1007/s42770-023-01086-z

Article  PubMed  PubMed Central  CAS  Google Scholar 

Badenschier Franziska B, Anja D, Alexandra S, Annika H, Bernhard S, Claudia P, Henrieke W-W, Christiane (2022) Külper-Schiek Wiebe, Wichmann Ole, Sing Andreas. Outbreak of imported diphtheria with Corynebacterium diphtheriae among migrants arriving in Germany, 2022. Euro Surveill. ;27(46):pii = 2200849. https://doi.org/10.2807/1560-7917.ES.2022.27.46.2200849

Batista Araujo MR, Bernardes Sousa MA, Seabra LF, Caldeira LA, Faria CD, Bokermann S et al (2021) Cutaneous infection by non-diphtheria-toxin producing and penicillin-resistant Corynebacterium diphtheriae strain in a patient with diabetes mellitus. Access Microbiol 3:284 1099/ acmi.0. 000284

Article  Google Scholar 

Billington SJ, Esmay PA, Songer JG, Jost BH (2002) Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis. FEMS Microbiol Lett 208(1):41–45. https://doi.org/10.1111/j.1574-6968.2002.tb11058.x

Article  PubMed  CAS  Google Scholar 

Brasil - Ministério da Saúde Situação epidemiológica: Tabela de casos de difteria 2019. Available in: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/d/difteria/situacao-epidemiologica

Brazilian Committee on Antimicrobial Susceptibility Testing (BrCAST) (2024) Tabelas de pontos de corte para interpretação de CIMs e diâmetros de halos. São Paulo: Available in https://brcast.org.br/documentos/documentos-3/

Brazilian Committee on Antimicrobial Susceptibility Testing (BrCAST). Método de Disco-Difusão para Teste de Sensibilidade aos Antimicrobianos. São Paulo (2018) Available in https://brcast.org.br/documentos/documentos-3/

Broadway MM, Rogers EA, Chang C, Huang IH, Dwivedi P, Yildirim S et al (2013) Pilus gene pool variation and the virulence of Corynebacterium diphtheriae clinical isolates during infection of a nematode. J Bacteriol 195:3774–3783. doi: 0.1128/JB.00500-13

Burkovski A (2014) Corynebacterium diphtheriae and related toxigenic species: Genomics, pathogenicity and applications. In: Burkovski A (ed) Corynebacterium diphtheriae and related toxigenic species: Genomics, pathogenicity and applications, vol 1. SpringeR, Dordrecht, pp 1–293. doi: https://doi.org/10.1007/978-94-007-7624-1.

Chapter  Google Scholar 

Cappelli EA, Ksiezarek M, Wolf J, Neumann-Schaal M, Ribeiro TG, Peixe L (2023) Expanding the bacterial diversity of the female urinary microbiome: description of eight New Corynebacterium Species. Microorganisms 11(2):388. https://doi.org/10.3390/microorganisms11020388

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chapartegui-González I, Fernández-Martínez M, Rodríguez-Fernández A, Rocha DJP, Aguiar ERGR, Pacheco LGC, Ramos-Vivas J, Calvo J, Martínez-Martínez L, Navas J (2020) Antimicrobial susceptibility and characterization of Resistance mechanisms of Corynebacterium urealyticum Clinical isolates. Antibiot (Basel) 9(7):404. https://doi.org/10.3390/antibiotics9070404

Article  CAS  Google Scholar 

Chaturvedi P, Singh A, Chowdhary P, Pandey A, Gupta P (2021) Occurrence of emerging sulfonamide resistance (sul1 and sul2) associated with mobile integrons-integrase (intI1 and intI2) in riverine systems. Sci Total Environ 751. https://doi.org/10.1016/J.SCITOTENV.2020.142217

Chopra I, Roberts M (2001) Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 65(2):232–260. https://doi.org/10.1128/MMBR.65.2.232-260.2001. second page, table of contents

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chun J, Oren A, Ventosa A, Christensen H, Arahal DR, da Costa MS et al (2018) Proposed minimal standards for the use of genome data for the taxonomy of prokaryotes. Int J Syst Evol Microbiol 68:461–466 doi: IJSEM.0.002516/CITE/REFWORKS

Article  PubMed  CAS  Google Scholar 

Clinical Information - Diphtheria (2022) Accessed: October 18, 2023: https://www.cdc.gov/diphtheria/clinicians.html

Couvin D, Bernheim A, Toffano-Nioche C, Touchon M, Michalik J, Néron B, Rocha EPC, Vergnaud G, Gautheret D, Pourcel C (2018) CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins. Nucleic Acids Res 46(W1):W246–W251. https://doi.org/10.1093/nar/gky425

Article  PubMed  PubMed Central  CAS  Google Scholar 

Crestani C, Arcari G, Landier A, Passet V, Garnier D, Brémont S, Armatys N, Carmi-Leroy A, Toubiana J, Badell E, Brisse S (2023) Corynebacterium ramonii sp. nov., a novel toxigenic member of the Corynebacterium diphtheriae species complex. Res Microbiol 174(7):104113. https://doi.org/10.1016/j.resmic.2023.104113. Epub ahead of print. PMID: 37572824

Article  PubMed  CAS  Google Scholar 

Dangel A, Berger A, Rau J, Eisenberg T, Kämpfer P, Margos G et al (2020) Corynebacterium silvaticum sp. nov., a unique group of NTTB corynebacteria in wild boar and roe deer. Int J Syst Evol Microbiol 70:3614–3624. https://doi.org/10.1099/IJSEM.0.004195

Article  PubMed  CAS  Google Scholar 

de Oliveira Sant’Anna L, Dos Santos LS, Araújo MRB, da Rocha DJPG, Ramos JN, Baio PVP, Del Peloso PF, da Costa Ferreira Leite C, Peixoto RS, Almuzara M, Vay C, Barberis C, Sangal V, Burkovski A, Aguiar ERGR, Mattos-Guaraldi AL, Pacheco LGC, Vieira VV (2023) Corynebacterium guaraldiae sp. nov.: a new species of Corynebacterium from human infections. Braz J Microbiol 54(2):779–790. https://doi.org/10.1007/s42770-023-00938-y

Article  PubMed  PubMed Central  CAS  Google Scholar 

Drazek ES, Hammack CA, Schmitt MP (2000) Corynebacterium diphtheriae genes required for acquisition of iron from haemin and haemoglobin are homologous to ABC haemin transporters. Mol Microbiol 36(1):68–84. https://doi.org/10.1046/j.1365-2958.2000.01818.x

Article  PubMed  CAS  Google Scholar 

Fraz Z, Litt D, Duncan J, Mann G, Pike R et al (2019) Molecular epidemiology and antimicrobial resistance of Corynebacterium diphtheriae and Corynebacterium ulcerans strains isolated in the UK between 2004–2017. Access Microbiol 1:251. https://doi.org/10.1099/acmi.ac2019.po0110

Article  Google Scholar 

Graham R, Rathnayake I, Sandhu S, Bhandari M, Taunton C, Fisher V, Jennison A (2023) Genomic analysis of an outbreak of toxin gene bearing Corynebacterium diphtheriae in Northern Queensland, Australia reveals high level of genetic similarity. Epidemiol Infect 151:E92. https://doi.org/10.1017/S0950268823000699

Article  PubMed  PubMed Central  Google Scholar 

Hennart M, Panunzi LG, Rodrigues C, Gaday Q, Baines SL, Barros-Pinkelnig M, Carmi-Leroy A, Dazas M, Wehenkel AM, Didelot X, Toubiana J, Badell E, Brisse S (2020) Population genomics and antimicrobial resistance in Corynebacterium diphtheriae. Genome Med 12(1):107. https://doi.org/10.1186/s13073-020-00805-7

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hong KW, Asmah Hani AW, Nurul Aina Murni CA, Pusparani RR, Chong CK, Verasahib K, Yusoff WNW, Noordin NM, Tee KK, Yin WF, Yu CY, Ang GY, Chan KG (2017) Comparative genomic and phylogenetic analysis of a toxigenic clinical isolate of Corynebacterium diphtheriae strain B-D-16-78 from Malaysia. Infect Genet Evol 54:263–270 Epub 2017 Jul 12. PMID: 28711373

Article  PubMed  CAS  Google Scholar 

Husada D, Soegianto SDP, Kurniawati IS, Hendrata AP, Irawan E, Kartina L, Puspitasari D, Basuki PS (2019) Ismoedijanto. First-line antibiotic susceptibility pattern of toxigenic Corynebacterium diphtheriae in Indonesia. BMC Infect Dis 19(1):1049. https://doi.org/10.1186/s12879-019-4675-y

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ishikawa J, Chiba K, Kurita H, Satoh H (2006) Contribution of rpoB2 RNA polymerase beta subunit gene to rifampin resistance in Nocardia species. Antimicrob Agents Chemother 50(4):1342–1346. https://doi.org/10.1128/AAC.50.4.1342-1346.2006

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jankute M, Alderwick LJ, Moorey AR, Joe M, Gurcha SS, Eggeling L, Lowary TL, Dell A, Pang PC, Yang T, Haslam S, Besra GS (2018) The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis. Cell Surf 2:38–53. https://doi.org/10.1016/j.tcsw.2018.06.003

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jolley KA, Bliss CM, Bennett JS, Bratcher HB, Brehony C, Colles FM et al (2012) Ribosomal multilocus sequence typing: universal characterization of bacteria from domain to strain. Microbiol (N Y) 158(4):1005–1015. https://doi.org/10.1099/mic.0.055459-0

Article  CAS 

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