Investigating the Role of KLF6-SV1 as a Regulator of EMT Progression

Suhail, Y., Cain, M.P., Vanaja, K., Kurywchak, P.A., Levchenko, A., Kalluri, R., et al., Systems biology of cancer metastasis, Cell Syst., 2019, vol. 9, no. 2, pp. 109–127.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seyfried, T.N. and Huysentruyt, L.C., On the origin of cancer metastasis, Crit. Rev. Oncog., 2013, vol. 18, nos. 1–2, pp. 43–73. https://doi.org/10.1615/critrevoncog.v18.i1-2.40

Article  PubMed  PubMed Central  Google Scholar 

Oliveira-Ferrer, L., Legler, K., and Milde-Lan-gosch, K., Role of protein glycosylation in cancer metastasis, Semin. Cancer Biol., 2017, vol. 44, pp. 141–152. https://doi.org/10.1016/j.semcancer.2017.03.002

Article  CAS  PubMed  Google Scholar 

Miller, K.D., Nogueira, L., Devasia, T., Mariot-to, A.B., Yabroff, K.R., Jemal, A., Kramer, J., and Siegel, R.L., Cancer treatment and survivorship statistics, 2022, CA: Cancer J. Clin., 2022, vol. 72, no. 5, pp. 409–436. https://doi.org/10.3322/caac.21731

Article  PubMed  Google Scholar 

Odom, D.T., Dowell, R.D., Jacobsen, E.S., Nekludova, L., Rolfe, P.A., Danford, T.W., Gifford, D.K., Fraenkel, E., Bell, G.I., and Young, R.A., Core transcriptional regulatory circuitry in human hepatocytes, Mol. Syst. Biol., 2006, vol. 2, p. 2006.0017. https://doi.org/10.1038/msb4100059

Sinha, U.K. and Lin, D.-C., A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy, Theranostics, 2023, vol. 13, no. 6, pp. 1823–1825. https://doi.org/10.7150/thno.83486

Article  PubMed  PubMed Central  Google Scholar 

Zhou, B. and Guo, R., Genomic and regulatory characteristics of significant transcription factors in colorectal cancer metastasis, Sci. Rep., 2018, vol. 8, no. 1, p. 17836. https://doi.org/10.1038/s41598-018-36168-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaczynski, J., Cook, T., and Urrutia, R., Sp1- and Krüppel-like transcription factors, Genome Biol., 2003, vol. 4, no. 2, p. 206. https://doi.org/10.1186/gb-2003-4-2-206

Article  PubMed  PubMed Central  Google Scholar 

Pollak, N.M., Hoffman, M., Goldberg, I.J., and Drosatos, K., Krüppel-like factors, JACC: Basic Transl. Sci., 2018, vol. 3, no. 1, pp. 132–156. https://doi.org/10.1016/j.jacbts.2017.09.001

Article  PubMed  Google Scholar 

Abe, M., Saeki, N., Ikeda, Y., and Ohba, S., Krüppel-like factors in skeletal physiology and pathologies, Int. J. Mol. Sci., 2022, vol. 23, no. 23, p. 15174. https://doi.org/10.3390/ijms232315174

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao, Z., Sun, X., Icli, B., Wara, A.K., and Feinberg, M.W., Role of Krüppel-like factors in leukocyte development, function, and disease, Blood, 2010, vol. 116, no. 22, pp. 4404–4414. https://doi.org/10.1182/blood-2010-05-285353

Article  CAS  PubMed  PubMed Central  Google Scholar 

McConnell, B.B. and Yang, V.W., Mammalian Krüppel-like factors in health and diseases, Physiol. Rev., 2010, vol. 90, no. 4, pp. 1337–1381. https://doi.org/10.1152/physrev.00058.2009

Article  CAS  PubMed  Google Scholar 

DiFeo, A., Narla, G., Hirshfeld, J., Camacho-Vanegas, O., Narla, J., Rose, S.L., Kalir, T., Yao, S., Levine, A., Birrer, M.J., Bonome, T., Friedman, S.L., Buller, R.E., and Martignetti, J.A., Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination, Clin. Cancer Res., 2006, vol. 12, no. 12, pp. 3730–3739. https://doi.org/10.1158/1078-0432.CCR-06-0054

Article  CAS  PubMed  Google Scholar 

Andreoli, V., Gehrau, R.C., and Bocco, J.L., Biology of Krüppel-like factor 6 transcriptional regulator in cell life and death, IUBMB Life, 2010, vol. 62, no. 12, pp. 896–905. https://doi.org/10.1002/iub.396

Article  CAS  PubMed  Google Scholar 

Orzechowska-Licari, E.J., LaComb, J.F., Mojumdar, A., and Bialkowska, A.B., SP and KLF transcription factors in cancer metabolism, Int. J. Mol. Sci., 2022, vol. 23, no. 17, p. 9956. https://doi.org/10.3390/ijms23179956

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, N.Y., Woda, B.A., Banner, B.F., Whalen, G.F., Dresser, K.A., and Lu, D., Sp1, a new biomarker that identifies a subset of aggressive pancreatic ductal adenocarcinoma, Cancer Epidemiol., Biomarkers Prev., 2008, vol. 17, no. 7, pp. 1648–1652. https://doi.org/10.1158/1055-9965.EPI-07-2791

Article  CAS  PubMed  Google Scholar 

Wang, X.-B., Peng, W.-Q., Yi, Z.-J., Zhu, S.-L., and Gan, Q.-H., Expression and prognostic value of transcriptional factor sp1 in breast cancer, Chin. J. Cancer, 2007, vol. 26, no. 9, pp. 996–1000.

CAS  Google Scholar 

Yao, J.C., Wang, L., Wei, D., Gong, W., Hassan, M., Wu, T.-T., Mansfield, P., Ajani, J., and Xie, K., Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer, Clin. Cancer Res., 2004, vol. 10, no. 12, pp. 4109–4117. https://doi.org/10.1158/1078-0432.CCR-03-0628

Article  CAS  PubMed  Google Scholar 

Reeves, H.L., Narla, G., Ogunbiyi, O., Haq, A.I., Katz, A., Benzeno, S., Hod, E., Harpaz, N., Goldberg, S., and Tal-Kremer, S., Krüppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer, Gastroenterology, 2004, vol. 126, no. 4, pp. 1090–1103. https://doi.org/10.1053/j.gastro.2004.01.005

Article  CAS  PubMed  Google Scholar 

Rubinstein, M., Idelman, G., Plymate, S.R., Narla, G., Friedman, S.L., and Werner, H., Transcriptional activation of the insulin-like growth factor I receptor gene by the Krüppel-like factor 6 (KLF6) tumor suppressor protein: Potential interactions between KLF6 and p53, Endocrinology, 2004, vol. 145, no. 8, pp. 3769–3777. https://doi.org/10.1210/en.2004-0173

Article  CAS  PubMed  Google Scholar 

Narla, G., DiFeo, A., Reeves, H.L., Schaid, D.J., Hirshfeld, J., Hod, E., Katz, A., Isaacs, W.B., Hebbring, S., Komiya, A., McDonnell, S.K., Wiley, K.E., Jacobsen, S.J., Isaacs, S. D., Walsh, P.C., Zheng, S.L., Chang, B.-L., Friedrichsen, D.M., Stanford, J.L., et al., A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk, Cancer Res., 2005, vol. 65, no. 4, pp. 1213–1222. https://doi.org/10.1158/0008-5472.CAN-04-4249

Article  CAS  PubMed  Google Scholar 

Choi, S., Cho, N., and Kim, K.K., The implications of alternative pre-mRNA splicing in cell signal transduction, Exp. Mol. Med., 2023, vol. 55, no. 4, pp. 755–766. https://doi.org/10.1038/s12276-023-00981-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Giammartino, D.C., Nishida, K., and Manley, J.L., Mechanisms and consequences of alternative polyadenylation, Mol. Cell., 2011, vol. 43, no. 6, pp. 853–866. https://doi.org/10.1016/j.molcel.2011.08.017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anczuków, O. and Krainer, A.R., Splicing-factor alterations in cancers, RNA, 2016, vol. 22, no. 9, pp. 1285–1301. https://doi.org/10.1261/rna.057919.116

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi, S., Cho, N., Kim, E.-M., and Kim, K.K., The role of alternative pre-mRNA splicing in cancer progression, Cancer Cell Int., 2023, vol. 23, no. 1, p. 249. https://doi.org/10.1186/s12935-023-03094-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatami, R., Sieuwerts, A.M., Izadmehr, S., Yao, Z., Qiao, R.F., Papa, L., Look, M.P., Smid, M., Ohlssen, J., Levine, A.C., Germain, D., Burstein, D., Kirschenbaum, A., DiFeo, A., Foekens, J.A., and Narla, G., KLF6-SV1 drives breast cancer metastasis and is associated with poor survival, Sci. Transl. Med., 2013, vol. 5, no. 169, p. 169ra12. https://doi.org/10.1126/scitranslmed.3004688

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalluri, R. and Weinberg, R.A., The basics of epithelial-mesenchymal transition, J. Clin. Invest., 2009, vol. 119, no. 6, pp. 1420–1428. https://doi.org/10.1172/JCI39104

Article  CAS 

Comments (0)

No login
gif