Beauchaine TP, Tackett JL. Irritability as a transdiagnostic vulnerability trait: current issues and future directions. Behav Ther. 2020;51:350–64. https://doi.org/10.1016/J.BETH.2019.10.009.

Article  PubMed  Google Scholar 

Leibenluft E, Stoddard J. The developmental psychopathology of irritability. Dev Psychopathol. 2013;25:1473–87. https://doi.org/10.1017/S0954579413000722.

Article  PubMed  PubMed Central  Google Scholar 

Brotman MA, Kircanski K, Stringaris A, Pine DS, Leibenluft E. Irritability in youths: a translational model. Am J Psychiatry. 2017;174:520–32. https://doi.org/10.1176/appi.ajp.2016.16070839.

Article  PubMed  Google Scholar 

Naim R, Haller SP, Linke JO, Jaffe A, Stoddard J, Jones M, et al. Context-dependent amygdala–prefrontal connectivity during the dot-probe task varies by irritability and attention bias to angry faces. Neuropsychopharmacology. 2022;47:2283–91. https://doi.org/10.1038/s41386-022-01307-3.

Article  PubMed  PubMed Central  Google Scholar 

Hirsch E, Hulvershorn L. Neural findings in pediatric irritability. In: Roy AK, Brotman MA, Leibenluft E, editors. Irritability in pediatric psychopathology. New York, NY: Oxford University Press; 2019. p. 171–94.

Zisner A, Beauchaine TP. Neural substrates of trait impulsivity, anhedonia, and irritability: mechanisms of heterotypic comorbidity between externalizing disorders and unipolar depression. Dev Psychopathol. 2016;28:1177–208. https://doi.org/10.1017/S0954579416000754.

Article  PubMed  Google Scholar 

Benarous X, Bury V, Lahaye H, Desrosiers L, Cohen D, Guilé JM. Sensory processing difficulties in youths with disruptive mood dysregulation disorder. Front Psychiatry. 2020;11:164. https://doi.org/10.3389/fpsyt.2020.00164.

Article  PubMed  PubMed Central  Google Scholar 

Toohey MJ, DiGiuseppe R. Defining and measuring irritability: construct clarification and differentiation. Clin Psychol Rev. 2017;53:93–108. https://doi.org/10.1016/j.cpr.2017.01.009.

Article  PubMed  Google Scholar 

Harima Y, Miyawaki D, Goto A, Hirai K, Sakamoto S, Hama H, et al. Associations between chronic irritability and sensory processing difficulties in children and adolescents. Front Psychiatry. 2022;13:860278 https://doi.org/10.3389/fpsyt.2022.860278.

Article  PubMed  PubMed Central  Google Scholar 

Tseng WL, Abend R, Gold AL, Brotman MA. Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability. J Affect Disord. 2021;295:920–9. https://doi.org/10.1016/J.JAD.2021.08.117.

Article  PubMed  PubMed Central  Google Scholar 

Gotlib IH, Traill SK, Montoya RL, Joormann J, Chang K. Attention and memory biases in the offspring of parents with bipolar disorder: indications from a pilot study. J Child Psychol Psychiatry. 2005;46:84–93. https://doi.org/10.1111/J.1469-7610.2004.00333.X.

Article  PubMed  Google Scholar 

Crum KI, Hwang S, Blair KS, Aloi JM, Meffert H, White SF, et al. Interaction of irritability and anxiety on emotional responding and emotion regulation: a functional MRI study. Psychol Med. 2021;51:2778–88. https://doi.org/10.1017/S0033291720001397.

Article  PubMed  Google Scholar 

Leigh E, Lee A, Brown HM, Pisano S, Stringaris A. A prospective study of rumination and irritability in youth. J Abnorm Child Psychol. 2020;48:1581–9. https://doi.org/10.1007/S10802-020-00706-8/TABLES/3.

Article  PubMed  PubMed Central  Google Scholar 

Copeland WE, Brotman MA, Costello EJ. Normative irritability in youth: developmental findings from the Great Smoky Mountains Study. J Am Acad Child Adolesc Psychiatry. 2015;54:635–42. https://doi.org/10.1016/j.jaac.2015.05.008.

Article  PubMed  PubMed Central  Google Scholar 

Vidal-Ribas P, Brotman MA, Valdivieso I, Leibenluft E, Stringaris A. The status of irritability in psychiatry: a conceptual and quantitative review. J Am Acad Child Adolesc Psychiatry. 2016;55:556–70. https://doi.org/10.1016/j.jaac.2016.04.014.

Article  PubMed  PubMed Central  Google Scholar 

Seok JW, Bajaj S, Soltis-Vaughan B, Lerdahl A, Garvey W, Bohn A, et al. Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability. Hum Brain Mapp. 2021;42:4611–22. https://doi.org/10.1002/hbm.25571.

Article  PubMed  PubMed Central  Google Scholar 

Chaarani B, Kan KJ, Mackey S, Spechler PA, Potter A, Banaschewski T, et al. Neural correlates of adolescent irritability and its comorbidity with psychiatric disorders. J Am Acad Child Adolesc Psychiatry. 2020;59:1371–9. https://doi.org/10.1016/j.jaac.2019.11.028.

Article  PubMed  Google Scholar 

Mulraney M, Sciberras E, Gulenc A, Efron D, Hazell P, Silk TJ. Neural correlates of irritability in a community sample of children. J Affect Disord. 2021;292:223–6. https://doi.org/10.1016/j.jad.2021.05.093.

Article  PubMed  Google Scholar 

Dennis EL, Humphreys KL, King LS, Thompson PM, Gotlib IH. Irritability and brain volume in adolescents: cross-sectional and longitudinal associations. Soc Cogn Affect Neurosci. 2019;14:687–98. https://doi.org/10.1093/scan/nsz053.

Article  PubMed  PubMed Central  Google Scholar 

Jirsaraie RJ, Kaczkurkin AN, Rush S, Piiwia K, Adebimpe A, Bassett DS, et al. Accelerated cortical thinning within structural brain networks is associated with irritability in youth. Neuropsychopharmacology. 2019;44:2254–62. https://doi.org/10.1038/s41386-019-0508-3.

Article  PubMed  PubMed Central  Google Scholar 

Piguet C, Mihailov A, Grigis A, Laidi C, Duchesnay E, Houenou J. Irritability is associated with decreased cortical surface area and anxiety with decreased gyrification during brain development. Front Psychiatry. 2021;12. https://doi.org/10.3389/FPSYT.2021.744419/FULL.

Gold AL, Brotman MA, Adleman NE, Lever SN, Steuber ER, Fromm SJ, et al. Comparing brain morphometry across multiple childhood psychiatric disorders. J Am Acad Child Adolesc Psychiatry. 2016;55:1027–37. https://doi.org/10.1016/j.jaac.2016.08.008.

Article  PubMed  PubMed Central  Google Scholar 

Cardinale EM, Kircanski K, Brooks J, Gold AL, Towbin KE, Pine DS, et al. Parsing neurodevelopmental features of irritability and anxiety: replication and validation of a latent variable approach. Dev Psychopathol. 2019;31:917–29. https://doi.org/10.1017/S095457941900035X.

Article  PubMed  PubMed Central  Google Scholar 

Bajaj S, Blair KS, Bashford-Largo J, Zhang R, Mathur A, Schwartz A, et al. Network-wise surface-based morphometric insight into the cortical neural circuitry underlying irritability in adolescents. Transl Psychiatry. 2021;11:581 https://doi.org/10.1038/s41398-021-01710-2.

Article  PubMed  PubMed Central  Google Scholar 

Damme KSF, Norton ES, Briggs-Gowan MJ, Wakschlag LS, Mittal VA. Developmental patterning of irritability enhances prediction of psychopathology in pre-adolescence: improving RDoC with developmental science. J Psychopathol Clin Sci. 2022;131:556–566. https://doi.org/10.1101/2020.04.30.070714.

Article  PubMed  PubMed Central  Google Scholar 

Pagliaccio D, Pine DS, Barch DM, Luby JL, Leibenluft E. Irritability trajectories, cortical thickness, and clinical outcomes in a sample enriched for preschool depression. J Am Acad Child Adolesc Psychiatry. 2018;57:336–42. https://doi.org/10.1016/j.jaac.2018.02.010.

Article  PubMed  PubMed Central  Google Scholar 

Ormel J, Jeronimus BF, Kotov R, Riese H, Bos EH, Hankin B, et al. Neuroticism and common mental disorders: meaning and utility of a complex relationship. Clin Psychol Rev. 2013;33:686–97. https://doi.org/10.1016/J.CPR.2013.04.003.

Article  PubMed  PubMed Central  Google Scholar 

Griffith JW, Zinbarg RE, Craske MG, Mineka S, Rose RD, Waters AM, et al. Neuroticism as a common dimension in the internalizing disorders. Psychol Med. 2010;40:1125–36. https://doi.org/10.1017/S0033291709991449.

Article  PubMed  CAS  Google Scholar 

Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJS. Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev. 2009;33:279–96. https://doi.org/10.1016/J.NEUBIOREV.2008.09.002.

Article  PubMed  Google Scholar 

Banich MT, Smith LL, Smolker HR, Hankin BL, Silton RL, Heller W, et al. Common and specific dimensions of internalizing disorders are characterized by unique patterns of brain activity on a task of emotional cognitive control.