Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608–611 (2009).

Article  CAS  PubMed  Google Scholar 

Bajaj, J., Diaz, E. & Reya, T. Stem cells in cancer initiation and progression. J. Cell Biol. 219, e201911053 (2020).

Article  PubMed  Google Scholar 

Shih, I.-M. et al. Top-down morphogenesis of colorectal tumors. Proc. Natl Acad. Sci. USA 98, 2640–2645 (2001).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schwitalla, S. et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152, 25–38 (2013).

Article  CAS  PubMed  Google Scholar 

Verhagen, M. P. et al. Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation. Nat. Genet. 56, 1456–1467 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, B. et al. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 184, 6262–6280.e26 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christ, A., Lauterbach, M. & Latz, E. Western diet and the immune system: an inflammatory connection. Immunity 51, 794–811 (2019).

Article  CAS  PubMed  Google Scholar 

Christ, A. et al. Western diet triggers NLRP3-dependent innate immune reprogramming. Cell 172, 162–175.e14 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tomasetti, C. & Vogelstein, B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347, 78–81 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spaander, M. C. W. et al. Young-onset colorectal cancer. Nat. Rev. Dis. Primers 9, 21 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Vuik, F. E. R., Nieuwenburg, S. A. V., Nagtegaal, I. D., Kuipers, E. J. & Spaander, M. C. W. Clinicopathological characteristics of early onset colorectal cancer. Aliment Pharmacol. Ther. 54, 1463–1471 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Accelerated aging may increase the risk of early-onset cancers in younger generations. AACR https://www.aacr.org/about-the-aacr/newsroom/news-releases/accelerated-aging-may-increase-the-risk-of-early-onset-cancers-in-younger-generations/ (2024).