Melatonin in infants—physiology, pathophysiology and intervention options

Paditz E (2024) Melatonin bei Schlafstörungen im Kindes- und Jugendalter. Monatsschr Kinderheilkd 172:44–51

Article  Google Scholar 

Lerner AB, Case JD, Takahashi Y, Lee TH, Mori W (1958) Isolation of melatonin, the pineal gland factor that lightens melanocytes1. J Am Chem Soc 80:2587–2587

Article  CAS  Google Scholar 

Lerner AB, Case JD, Heinzelman RV (1959) Structure of melatonin. J Am Chem Soc 81:6084–6085

Article  CAS  Google Scholar 

Paditz E, Renner B, Bauer M (2023) Melatoninstoffwechsel im Kindes- und Jugendalter. In: Schneider B, Aschmann-Mühlhans D (eds) Aktuelle Kinderschlafmedizin 2023. kleanthes, Dresden, pp 40–62

Google Scholar 

Paditz E, Hahn G (2023) Schlafstörungen infolge von Pinealistumoren im Kindes- und Jugendalter. In: Schneider B, Aschmann-Mühlhans D (eds) Aktuelle Kinderschlafmedizin 2023. kleanthes, Dresden, pp 63–80

Google Scholar 

Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J (2022) Is Melatonin the “next vitamin D”?: a review of emerging science, clinical uses, safety, and dietary supplements. Nutrients 14(19):3934

Falcón J, Coon SL, Besseau L, Cazaméa-Catalan D, Fuentès M, Magnanou E, Paulin CH, Boeuf G, Sauzet S, Jørgensen EH, Mazan S, Wolf YI, Koonin EV, Steinbach PJ, Hyodo S, Klein DC (2014) Drastic neofunctionalization associated with evolution of the timezyme AANAT 500 Mya. Proc Natl Acad Sci U S A 111:314–319

Article  PubMed  Google Scholar 

Illnerova H, Buresova M, Presl J (1993) Melatonin rhythm in human milk. J Clin Endocrinol Metab 77:838–841

CAS  PubMed  Google Scholar 

Eriksson L, Valtonen M, Laitinen JT, Paananen M, Kaikkonen M (1998) Diurnal rhythm of melatonin in bovine milk: pharmacokinetics of exogenous melatonin in lactating cows and goats. Acta Vet Scand 39:301–310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Behura SS, Dhanawat A, Nayak B, Panda SK (2022) Comparison between oral melatonin and 24 % sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial. TurkJPediatr 64:1013–1020

Article  Google Scholar 

Vásquez-Ruiz S, Maya-Barrios JA, Torres-Narváez P, Vega-Martínez BR, Rojas-Granados A, Escobar C, Angeles-Castellanos M (2014) A light/dark cycle in the NICU accelerates body weight gain and shortens time to discharge in preterm infants. Early Hum Dev 90:535–540

Article  PubMed  Google Scholar 

Gitto E, Aversa S, Salpietro CD, Barberi I, Arrigo T, Trimarchi G, Reiter RJ, Pellegrino S (2012) Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant. J Pineal Res 52:291–295

Article  CAS  PubMed  Google Scholar 

Cubero J, Valero V, Sanchez J, Rivero M, Parvez H, Rodriguez AB, Barriga C (2005) The circadian rhythm of tryptophan in breast milk affects the rhythms of 6‑sulfatoxymelatonin and sleep in newborn. Neuro Endocrinol Lett 26:657–661

CAS  PubMed  Google Scholar 

Merchant NM, Azzopardi DV, Hawwa AF, McElnay JC, Middleton B, Arendt J, Arichi T, Gressens P, Edwards AD (2013) Pharmacokinetics of melatonin in preterm infants. Brit J Clinical Pharma 76:725–733

Article  CAS  Google Scholar 

Voiculescu SE, Zygouropoulos N, Zahiu CD, Zagrean AM (2014) Role of melatonin in embryo fetal development. JMedLife 7:488–492

CAS  Google Scholar 

Joseph D, Chong NW, Shanks ME, Rosato E, Taub NA, Petersen SA, Symonds ME, Whitehouse WP, Wailoo M (2015) Getting rhythm: how do babies do it? Arch Dis Child Fetal Neonatal Ed 100:F50–F54

Article  PubMed  Google Scholar 

Paditz E Chronobiologische Säuglingsnahrung und Verfahren zu deren Herstellung. WIPO/PCT/WO2023134856A1 v. 20.07.2023. https://worldwide.espacenet.com/patent/search/family/080123321/publication/WO2023135228A1?q=pn%3DWO2023135228

Aparicio S, Garau C, Esteban S, Nicolau MC, Rivero M, Rial RV (2007) Chrononutrition: use of dissociated day/night infant milk formulas to improve the development of the wake-sleep rhythms. Effects of tryptophan. Nutr Neurosci 10:137–143

Article  CAS  PubMed  Google Scholar 

Cubero J, Narciso D, Aparicio S, Garau C, Valero V, Rivero M, Esteban S, Rial R, Rodríguez AB, Barriga C (2006) Improved circadian sleep-wake cycle in infants fed a day/night dissociated formula milk. Neuro Endocrinol Lett 27:373–380

CAS  PubMed  Google Scholar 

Hahn-Holbrook J, Saxbe D, Bixby C, Steele C, Glynn L (2019) Human milk as “chrononutrition”: implications for child health and development. Pediatr Res 85:936–942

Article  PubMed  Google Scholar 

White RD (2017) Circadian variation of breast milk components and implications for care. Breastfeed Med 12:398–400

Article  PubMed  Google Scholar 

Cubero J, Narciso D, Terron P, Rial R, Esteban S, Rivero M, Parvez H, Rodriguez AB, Barriga C (2007) Chrononutrition applied to formula milks to consolidate infants’ sleep/wake cycle. Neuro Endocrinol Lett 28:360–366

CAS  PubMed  Google Scholar 

Caba-Flores MD, Ramos-Ligonio A, Camacho-Morales A, Martínez-Valenzuela C, Viveros-Contreras R, Caba M (2022) Breast milk and the importance of chrononutrition. Front Nutr 9:867507

Article  PubMed  PubMed Central  Google Scholar 

Aparici-Gonzalo S, Carrasco-García Á, Gombert M, Carrasco-Luna J, Pin-Arboledas G, Codoñer-Franch P (2020) Melatonin content of human milk: the effect of mode of delivery. Breastfeed Med 15:589–594

Article  PubMed  Google Scholar 

Qin Y, Shi W, Zhuang J, Liu Y, Tang L, Bu J, Sun J, Bei F (2019) Variations in melatonin levels in preterm and term human breast milk during the first month after delivery. Sci Rep 9:17984

Article  PubMed  PubMed Central  Google Scholar 

Katzer D, Pauli L, Mueller A, Reutter H, Reinsberg J, Fimmers R, Bartmann P, Bagci S (2016) Melatonin concentrations and antioxidative capacity of human breast milk according to gestational age and the time of day. J Hum Lact 32(Np105):np110

Google Scholar 

Sadeh A (1997) Sleep and melatonin in infants: a preliminary study. Sleep 20:185–191

CAS  PubMed  Google Scholar 

Carloni S, Proietti F, Rocchi M, Longini M, Marseglia L, D’Angelo G, Balduini W, Gitto E, Buonocore G (2017) Melatonin pharmacokinetics following oral administration in preterm neonates. Molecules 22:2115

Article  PubMed  PubMed Central  Google Scholar 

Andersen LP, Werner MU, Rosenkilde MM, Harpsøe NG, Fuglsang H, Rosenberg J, Gögenur I (2016) Pharmacokinetics of oral and intravenous melatonin in healthy volunteers. Bmc Pharmacol Toxicol 17:8

Article  PubMed  PubMed Central  Google Scholar 

Ucuncu Egeli T, Tufekci KU, Ural C, Durur DY, Tuzun Erdogan F, Cavdar Z, Genc S, Keskinoglu P, Duman N, Ozkan H (2023) A new perspective on the pathogenesis of infantile colic: is infantile colic a biorhythm disorder? J Pediatr Gastroenterol Nutr 77:171–177

Article  CAS  PubMed  Google Scholar 

Perrone S, Romeo C, Marseglia L, Manti S, Rizzo C, Carloni S, Albertini MC, Balduini W, Buonocore G, Weiss MD, Gitto E (2023) Melatonin in newborn infants undergoing surgery: a pilot study on its effects on postoperative oxidative stress. Antioxidants 12:563

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marseglia L, Manti S, D’Angelo G, Arrigo T, Cuppari C, Salpietro C, Gitto E (2015) Potential use of melatonin in procedural anxiety and pain in children undergoing blood withdrawal. J Biol Regul Homeost Agents 29:509–514

CAS  PubMed  Google Scholar 

Cannavò L, Perrone S, Marseglia L, Viola V, Di Rosa G, Gitto E (2022) Potential benefits of melatonin to control pain in ventilated preterm newborns: An updated review. Pain Pract 22:248–254

Article  PubMed  Google Scholar 

Aly H, Elmahdy H, El-Dib M, Rowisha M, Awny M, El-Gohary T, Elbatch M, Hamisa M, El-Mashad AR (2015) Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study. J Perinatol 35:186–191

Article  CAS  PubMed  Google Scholar 

Ahmad QM, Chishti AL, Waseem N (2018) Role of melatonin in management of hypoxic ischaemic encephalopathy in newborns: a randomized control trial. J Pak Med Assoc 68:1233–1237

PubMed  Google Scholar 

Fulia F, Gitto E, Cuzzocrea S, Reiter RJ, Dugo L, Gitto P, Barberi S, Cordaro S, Barberi I (2001) Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin. J Pineal Res 31:343–349

Article  CAS  PubMed 

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