An Z, Yin Y, Zhang L et al (2022) Effect of Ulinastatin Combined with Xingnaojing Injection on Severe Traumatic Craniocerebral Injury and Its Influence on Oxidative Stress Response and Inflammatory Response. Biomed Res Int 2022:2621732

Article  PubMed  PubMed Central  Google Scholar 

Cetiner M, Eskut N, Akdag G et al (2023) Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke. Sisli Etfal Hastan Tip Bul 57:359–366

Article  PubMed  PubMed Central  Google Scholar 

Chen M, Zhang Q, Liu H et al (2021) Influence of nimodipine combined with ulinastatin on neurological function and inflammatory reaction in patients with cerebral vasospasm after subarachnoid hemorrhage. Clin Neurol Neurosurg 210:106981

Article  PubMed  Google Scholar 

Chinen T, Kobayashi T, Ogata H et al (2006) Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology 130:373–388

Article  CAS  PubMed  Google Scholar 

Cui P, Lu W, Wang J et al (2023) Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model. J Neuroinflammation 20:63

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding W, Gu Q, Liu M et al (2023) Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway. Int Immunopharmacol 118:110047

Article  CAS  PubMed  Google Scholar 

Egan PJ, Lawlor KE, Alexander WS et al (2003) Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest 111:915–924

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faizy TD, Mlynash M, Marks MP et al (2022) Intravenous tPA (Tissue-Type Plasminogen Activator) Correlates With Favorable Venous Outflow Profiles in Acute Ischemic Stroke. Stroke 53:3145–3152

Article  CAS  PubMed  Google Scholar 

Hajinejad M, Ebrahimzadeh MH, Ebrahimzadeh-Bideskan A et al (2023) Exosomes and Nano-SDF Scaffold as a Cell-Free-Based Treatment Strategy Improve Traumatic Brain Injury Mechanisms by Decreasing Oxidative Stress, Neuroinflammation, and Increasing Neurogenesis. Stem Cell Rev Rep 19:1001–1018

Article  CAS  PubMed  Google Scholar 

Hartmann H, Hoehne K, Rist E et al (2015) miR-124 disinhibits neurite outgrowth in an inflammatory environment. Cell Tissue Res 362:9–20

Article  CAS  PubMed  Google Scholar 

Li Y, Zhao L, Fu H et al (2015) Ulinastatin suppresses lipopolysaccharide induced neuro-inflammation through the downregulation of nuclear factor-kappaB in SD rat hippocampal astrocyte. Biochem Biophys Res Commun 458:763–770

Article  CAS  PubMed  Google Scholar 

Lian L, Zhang Y, Liu L et al (2020) Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia. Front Mol Neurosci 13:612439

Article  CAS  PubMed  Google Scholar 

Liu X, Zhang M, Liu H et al (2021) Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes. Exp Neurol 341:113700

Article  CAS  PubMed  Google Scholar 

Liu Q, Shen Y, Xiao Y et al (2022) Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4Ralpha. Inflamm Res 71:1271–1282

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo Y, Li J, Huang L et al (2022) Safety and efficacy of a new modified intravenous recombinant tissue plasminogen activator (rt-PA) regimen in Chinese patients with acute ischemic stroke: A descriptive retrospective cohort study with subgroup-analysis of different rt-PA dose. J Clin Neurosci 101:244–251

Article  CAS  PubMed  Google Scholar 

Madonna S, Scarponi C, De Pita O et al (2008) Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation. FASEB J 22:3287–3297

Article  CAS  PubMed  Google Scholar 

Maier B, Tsai AS, Einhaus JF et al (2023) Neuroimaging is the new “spatial omic”: multi-omic approaches to neuro-inflammation and immuno-thrombosis in acute ischemic stroke. Semin Immunopathol 45:125–143

Article  PubMed  PubMed Central  Google Scholar 

Mavroudis I, Balmus IM, Ciobica A, et al (2023) The Role of Microglial Exosomes and miR-124–3p in Neuroinflammation and Neuronal Repair after Traumatic Brain Injury. Life (Basel) 13(9):1924. https://doi.org/10.3390/life13091924

Nagy EE, Frigy A, Szasz JA et al (2020) Neuroinflammation and microglia/macrophage phenotype modulate the molecular background of post-stroke depression: A literature review. Exp Ther Med 20:2510–2523

CAS  PubMed  PubMed Central  Google Scholar 

Neki H, Katano T, Maeda T et al (2023) Intraarterial urokinase for thrombus migration after mechanical thrombectomy for large vessel ischemic stroke. Interv Neuroradiol 29:88–93

Article  PubMed  Google Scholar 

Pan R, Xie Y, Fang W et al (2022) USP20 mitigates ischemic stroke in mice by suppressing neuroinflammation and neuron death via regulating PTEN signal. Int Immunopharmacol 103:107840

Article  CAS  PubMed  Google Scholar 

Pu Z, Xia S, Shao P, et al (2022) Regulation of Microglia-Activation-Mediated Neuroinflammation to Ameliorate Ischemia-Reperfusion Injury via the STAT5-NF-kappaB Pathway in Ischemic Stroke. Brain Sci 12(9):1153. https://doi.org/10.3390/brainsci12091153

Shikimi T, Himeno Y, Shigeno K et al (1994) Relationships between ulinastatin and alpha-1-microglobulin in human urine. Clin Chim Acta 227:195–200

Article  CAS  PubMed  Google Scholar 

Su Y, Zhang Y, Yuan H et al (2022) Efficacy of Xuebijing Combined with Ulinastatin in the Treatment of Traumatic Sepsis and Effects on Inflammatory Factors and Immune Function in Patients. Front Surg 9:899753

Article  PubMed  PubMed Central  Google Scholar 

Su W, Lu H, Li Q, et al (2023) Characteristics of cognition impairment in patients after stroke based on the Wechsler Adult Intelligence Scale-Revised in China. Appl Neuropsychol Adult 1–8. https://doi.org/10.1080/23279095.2023.2205023

Sun X, Song W, Teng L et al (2023) MiRNA 24–3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogels for corneal epithelial healing. Bioact Mater 25:640–656

CAS  PubMed  Google Scholar 

Tajiri K, Imanaka-Yoshida K, Matsubara A et al (2012) Suppressor of cytokine signaling 1 DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis. J Immunol 189:2043–2053

Article  CAS  PubMed  Google Scholar 

Teran-Cabanillas E, Montalvo-Corral M, Silva-Campa E et al (2014) Production of interferon alpha and beta, pro-inflammatory cytokines and the expression of suppressor of cytokine signaling (SOCS) in obese subjects infected with influenza A/H1N1. Clin Nutr 33:922–926

Article  CAS  PubMed  Google Scholar 

van der Ende NAM, Roozenbeek B, Smagge LEM et al (2023) Safety and Efficacy of Dual Thrombolytic Therapy With Mutant Prourokinase and Small Bolus Alteplase for Ischemic Stroke: A Randomized Clinical Trial. JAMA Neurol 80:714–722

Article  PubMed  Google Scholar 

Wang Y, Leak RK, Cao G (2022) Microglia-mediated neuroinflammation and neuroplasticity after stroke. Front Cell Neurosci 16:980722

Article  PubMed  PubMed Central  Google Scholar 

Wei YJ, Wang JF, Cheng F et al (2021) miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1alpha pathway. J Physiol Biochem 77:577–587

Article  CAS  PubMed  Google Scholar 

Xu C, Gao S (2023) Commentary: Safety and efficacy of low-cost alternative urokinase in acute ischemic stroke: A systematic review and meta-analysis. J Clin Neurosci 115:169

Article  CAS  PubMed  Google Scholar 

Yu A, Zhang T, Duan H et al (2017) MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-alpha pathway in intracerebral hemorrhage. Immunol Lett 182:1–11

Article