Amos A, Jiang N, Zong D, Gu J, Zhou J, Yin L et al (2023) Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition. BMC Cancer 23(1):117
CAS PubMed PubMed Central Google Scholar
Anandhan A, Dodson M, Shakya A, Chen J, Liu P, Wei Y et al (2023) NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Sci Adv 9(5):eade9585
CAS PubMed PubMed Central Google Scholar
Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (2000) A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. EMBO J 19(23):6453–6464
CAS PubMed PubMed Central Google Scholar
Arends MJ (2013) Pathways of colorectal carcinogenesis. Appl Immunohistochem Mol Morphol 21(2):97–102
Behrendorff N, Dolai S, Hong W, Gaisano HY, Thorn P (2011) Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion. J Biol Chem 286(34):29627–29634
CAS PubMed PubMed Central Google Scholar
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
Cao J, Tang Z, Su Z (2020) Long non-coding RNA LINC01426 facilitates glioblastoma progression via sponging miR-345-3p and upregulation of VAMP8. Cancer Cell Int 20:327
CAS PubMed PubMed Central Google Scholar
Chen Y, Meng D, Wang H, Sun R, Wang D, Wang S et al (2015) VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells. Neuro Oncol 17(3):407–418
Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F et al (2016) Cancer statistics in China, 2015. CA Cancer J Clin 66(2):115–132
Chen Q, Hao M, Wang L, Li L, Chen Y, Shao X et al (2021a) Prefused lysosomes cluster on autophagosomes regulated by VAMP8. Cell Death Dis 12(10):939
CAS PubMed PubMed Central Google Scholar
Chen X, Kang R, Kroemer G, Tang D (2021b) Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol 18(5):280–296
Chen J, Qin C, Zhou Y, Chen Y, Mao M, Yang J (2022) Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer. FEBS Open Bio 12(1):146–153
De Rosa M, Pace U, Rega D, Costabile V, Duraturo F, Izzo P et al (2015) Genetics, diagnosis and management of colorectal cancer (Review). Oncol Rep 34(3):1087–1096
Dinakar YH, Kumar H, Mudavath SL, Jain R, Ajmeer R, Jain V (2022) Role of STAT3 in the initiation, progression, proliferation and metastasis of breast cancer and strategies to deliver JAK and STAT3 inhibitors. Life Sci 309:120996
Du W, Hong J, Wang YC, Zhang YJ, Wang P, Su WY et al (2012) Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. J Cell Mol Med 16(8):1878–1888
CAS PubMed PubMed Central Google Scholar
Furuta N, Fujita N, Noda T, Yoshimori T, Amano A (2010) Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol Biol Cell 21(6):1001–1010
CAS PubMed PubMed Central Google Scholar
Hasan N, Hu C (2010) Vesicle-associated membrane protein 2 mediates trafficking of alpha5beta1 integrin to the plasma membrane. Exp Cell Res 316(1):12–23
Jahn R, Scheller RH (2006) SNAREs–engines for membrane fusion. Nat Rev Mol Cell Biol 7(9):631–643
Johnson DE, O’Keefe RA, Grandis JR (2018) Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol 15(4):234–248
CAS PubMed PubMed Central Google Scholar
Lao VV, Grady WM (2011) Epigenetics and colorectal cancer. Nat Rev Gastroenterol Hepatol 8(12):686–700
CAS PubMed PubMed Central Google Scholar
Lau SK, Boutros PC, Pintilie M, Blackhall FH, Zhu CQ, Strumpf D et al (2007) Three-gene prognostic classifier for early-stage non small-cell lung cancer. J Clin Oncol 25(35):5562–5569
Lech G, Słotwiński R, Słodkowski M, Krasnodębski IW (2016) Colorectal cancer tumour markers and biomarkers: recent therapeutic advances. World J Gastroenterol 22(5):1745–1755
CAS PubMed PubMed Central Google Scholar
Li X, Liu J (2023) FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma. BMC Cancer 23(1):179
CAS PubMed PubMed Central Google Scholar
Li X, He S, Ma B (2020) Autophagy and autophagy-related proteins in cancer. Mol Cancer 19(1):12
CAS PubMed PubMed Central Google Scholar
Li Y, Zhang Y, Qiu Q, Wang L, Mao H, Hu J et al (2022) Energy-stress-mediated AMPK activation promotes GPX4-dependent ferroptosis through the JAK2/STAT3/p53 axis in renal cancer. Oxid Med Cell Longev 2022:2353115
PubMed PubMed Central Google Scholar
Li Q, Ding Y, Ou Y, Li M, Jithavech P, Buranasudja V et al (2023) Curcuminoids modulated the IL-6/JAK/STAT3 signaling pathway in LoVo and HT-29 colorectal cancer cells. Curr Pharm Des 29(36):2867–2876
Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I et al (2005) Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol 167(4):969–980
CAS PubMed PubMed Central Google Scholar
Long J, Yao Z, Sui Y, Fang S (2022) SphK1 promotes cancer progression through activating JAK/STAT pathway and up-regulating s1pr1 expression in colon cancer cells. Anticancer Agents Med Chem 22(2):254–260
Mazzotti F, Cucchetti A, Claassen YHM, Bos A, Bastiaannet E, Ercolani G et al (2019) Years of life lost for older patients after colorectal cancer diagnosis. World J Surg 43(8):2077–2085
Ohnishi Y, Tsuji D, Itoh K (2022) Oxidative stress impairs autophagy via inhibition of lysosomal transport of VAMP8. Biol Pharm Bull 45(11):1609–1615
Peng RW, Abellan E, Fussenegger M (2011) Differential effect of exocytic SNAREs on the production of recombinant proteins in mammalian cells. Biotechnol Bioeng 108(3):611–620
Pennel KAF, Hatthakarnkul P, Wood CS, Lian GY, Al-Badran SSF, Quinn JA et al (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. J Exp Clin Cancer Res 43(1):64
CAS PubMed PubMed Central Google Scholar
Pontén F, Jirström K, Uhlen M (2008) The Human Protein Atlas–a tool for pathology. J Pathol 216(4):387–393
Rajabi S, Tahmasvand Z, Maresca M, Hamzeloo-Moghadam M (2024) Gaillardin inhibits autophagy and induces apoptosis in MCF-7 breast cancer cells by regulating JAK/STAT pathway. Mol Biol Rep 51(1):158
Rorsman P, Braun M (2013) Regulation of insulin secretion in human pancreatic islets. Annu Rev Physiol 75:155–179
Scheller RH (2013) In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release. Nat Med 19(10):1232–1235
Siegel RL, Miller KD (2019) Cancer statistics, 2019. CA Cancer J Clin 69(1):7–34
Comments (0)