Equivalent thrombotic risk with Warfarin, Dabigatran, or Enoxaparin after failure of initial direct oral anticoagulation (DOAC) therapy

Turpie AGG, Farjat AE, Haas S, Ageno W, Weitz JI, Goldhaber SZ et al (2023) 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE. Thromb Res 222:31–39. https://doi.org/10.1016/j.thromres.2022.11.016

Article  CAS  PubMed  Google Scholar 

Bauersachs R, Berkowitz SD, Brenner B, Buller HR, Decousus H, Gallus AS et al (2010) Oral Rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 363(26):2499–2510. https://doi.org/10.1056/NEJMoa1007903

Article  CAS  PubMed  Google Scholar 

Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M et al (2013) Oral apixaban for the treatment of Acute venous thromboembolism. N Engl J Med 369(9):799–808. https://doi.org/10.1056/NEJMoa1302507

Article  CAS  PubMed  Google Scholar 

Khan F, Tritschler T, Kimpton M, Wells PS, Kearon C, Weitz JI et al (2021) Long-term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: a systematic review and meta‐analysis. J Thromb Haemost 19(11):2801–2813. https://doi.org/10.1111/jth.15491

Article  PubMed  Google Scholar 

Elsebaie MAT, Van Es N, Langston A, Büller HR, Gaddh M (2019) Direct oral anticoagulants in patients with venous thromboembolism and thrombophilia: a systematic review and meta-analysis. J Thromb Haemost 17(4):645–656. https://doi.org/10.1111/jth.14398

Article  PubMed  Google Scholar 

Schulman S, Zondag M, Linkins L, Pasca S, Cheung YW, De Sancho M et al (2015) Recurrent venous thromboembolism in anticoagulated patients with cancer: management and short-term prognosis. J Thromb Haemost 13(6):1010–1018. https://doi.org/10.1111/jth.12955

Article  CAS  PubMed  Google Scholar 

Young AM, Marshall A, Thirlwall J, Chapman O, Lokare A, Hill C et al (2018) Comparison of an oral factor xa inhibitor with low Molecular Weight Heparin in patients with Cancer with venous thromboembolism: results of a Randomized Trial (SELECT-D). J Clin Oncol 36(20):2017–2023. https://doi.org/10.1200/jco.2018.78.8034

Article  CAS  PubMed  Google Scholar 

Agnelli G, Becattini C, Meyer G, Muñoz A, Huisman MV, Connors JM et al (2020) Apixaban for the treatment of venous Thromboembolism Associated with Cancer. N Engl J Med 382(17):1599–1607. https://doi.org/10.1056/nejmoa1915103

Article  CAS  PubMed  Google Scholar 

Mcilroy G, Smith N, Lokare A, Beale K, Kartsios C (2020) Management of venous thromboembolism in patients experiencing direct oral anticoagulant treatment failure: a single-center review of practice and outcomes. J Thromb Thrombolysis 49(3):441–445. https://doi.org/10.1007/s11239-020-02042-6

Article  PubMed  Google Scholar 

Schulman S, Kearon C (2005) Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 3(4):692–694. https://doi.org/10.1111/j.1538-7836.2005.01204.x

Article  CAS  PubMed  Google Scholar 

Schulman S (2017) How I treat recurrent venous thromboembolism in patients receiving anticoagulant therapy. Blood 129(25):3285–3293. https://doi.org/10.1182/blood-2017-03-742304

Article  CAS  PubMed  Google Scholar 

Schulman S, Kakkar AK, Goldhaber SZ, Schellong S, Eriksson H, Mismetti P et al (2014) Treatment of Acute venous thromboembolism with Dabigatran or Warfarin and Pooled Analysis. Circulation 129(7):764–772. https://doi.org/10.1161/circulationaha.113.004450

Article  CAS  PubMed  Google Scholar 

Carrier M, Le Gal G, Cho R, Tierney S, Rodger M, Lee AY (2009) Dose escalation of low molecular weight heparin to manage recurrent venous thromboembolic events despite systemic anticoagulation in cancer patients. J Thromb Haemost 7(5):760–765. https://doi.org/10.1111/j.1538-7836.2009.03326.x

Article  CAS  PubMed  Google Scholar 

Ihaddadene R, Gal GL, Delluc A, Carrier M (2014) Dose escalation of low molecular weight heparin in patients with recurrent cancer-associated thrombosis. Thromb Res 134(1):93–95. https://doi.org/10.1016/j.thromres.2014.04.028

Article  CAS  PubMed  Google Scholar 

Lyman GH, Carrier M, Ay C, Nisio MD, Hicks LK, Khorana AA et al (2021) American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv 5(4):927–974. https://doi.org/10.1182/bloodadvances.2020003442

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carrier M, Khorana AA, Zwicker JI, Noble S, Lee AYY (2013) Management of challenging cases of patients with cancer-associated thrombosis including recurrent thrombosis and bleeding: guidance from the SSC of the ISTH. J Thromb Haemost 11(9):1760–1765. https://doi.org/10.1111/jth.12338

Article  CAS  PubMed  Google Scholar 

Gervaso L, Dave H, Khorana AA (2021) Venous and arterial thromboembolism in patients with Cancer: JACC CardioOncology State-of-the-art review. JACC CardioOncol 3(2):173–190. https://doi.org/10.1016/j.jaccao.2021.03.001

Article  PubMed  PubMed Central  Google Scholar 

Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI et al (2020) Venous thromboembolism prophylaxis and treatment in patients with Cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol 38(5):496–520. https://doi.org/10.1200/jco.19.01461

Article  PubMed  Google Scholar 

O’Connell C, Escalante CP, Goldhaber SZ, Mcbane R, Connors JM, Raskob GE (2021) Treatment of Cancer-Associated venous thromboembolism with low-molecular-weight heparin or direct oral anticoagulants: patient selection, controversies, and caveats. Oncologist 26(1):e8–e16. https://doi.org/10.1002/onco.13584

Article  CAS  PubMed  Google Scholar 

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