Nguyen NT, Chinn J, Nahmias J, Yuen S, Kirby KA, Hohmann S, Amin A (2021) Outcomes and Mortality Among Adults Hospitalized With COVID-19 at US Medical Centers. Jama Netw Open 4. https://doi.org/10.1001/jamanetworkopen.2021.0417
Challen R, Brooks-Pollock E, Read JM, Dyson L, Tsaneva-Atanasova K, Danon L (2021) Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study. BMJ 372:n579. https://doi.org/10.1136/bmj.n579
Zhang L, Feng X, Zhang D, Jiang C, Mei H, Wang J, Zhang C, Li H, Xia X, Kong S, Liao J, Jia H, Pang X, Song Y, Tian Y, Wang B, Wu C, Yuan H, Zhang Y et al (2020) Deep Vein Thrombosis in Hospitalized Patients With COVID-19 in Wuhan, China: Prevalence, Risk Factors, and Outcome. Circulation 142:114–128. https://doi.org/10.1161/CIRCULATIONAHA.120.046702
Article CAS PubMed Google Scholar
Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA (2020) Platelet gene expression and function in patients with COVID-19. Blood 136:1317–1329. https://doi.org/10.1182/blood.2020007214
Article CAS PubMed Google Scholar
Xu XR, Zhang D, Oswald BE, Carrim N, Wang X, Hou Y, Zhang Q, Lavalle C, McKeown T, Marshall AH, Ni H (2016) Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond. Crit Rev Clin Lab Sci 53:409–430. https://doi.org/10.1080/10408363.2016.1200008
Article CAS PubMed Google Scholar
Yeung J, Li W, Holinstat M (2018) Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases. Pharmacol Rev 70:526–548. https://doi.org/10.1124/pr.117.014530
Article CAS PubMed PubMed Central Google Scholar
Makowski L, Olson-Sidford W, Weisel JW (2021) Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein. Viruses 13. https://doi.org/10.3390/v13020146
Huang J, Li X, Shi X, Zhu M, Wang J, Huang S, Huang X, Wang H, Li L, Deng H, Zhou Y, Mao J, Long Z, Ma Z, Ye W, Pan J, Xi X, Jin J (2019) Platelet integrin alphaIIbbeta3: signal transduction, regulation, and its therapeutic targeting. J Hematol Oncol 12:26. https://doi.org/10.1186/s13045-019-0709-6
Article PubMed PubMed Central Google Scholar
Ma X, Liang J, Zhu G, Bhoria P, Shoara AA, MacKeigan DT, Khoury CJ, Slavkovic S, Lin L, Karakas D, Chen Z, Prifti V, Liu Z, Shen C, Li Y, Zhang C, Dou J, Rousseau Z, Zhang J et al (2023) SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19. Research (Wash D C) 6:0124. https://doi.org/10.34133/research.0124
Article CAS PubMed Google Scholar
Ya F, Xu XR, Shi Y, Gallant RC, Song F, Zuo X, Zhao Y, Tian Z, Zhang C, Xu X, Ling W, Ni H, Yang Y (2019) Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin alphaIIbbeta3 Signaling and Thrombus Growth. Mol Nutr Food Res 63:e1900662. https://doi.org/10.1002/mnfr.201900662
Article CAS PubMed Google Scholar
Li T, Yang Y, Li Y, Wang Z, Ma F, Luo R, Xu X, Zhou G, Wang J, Niu J, Lv G, Crispe IN, Tu Z (2022) Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein. J Clin Invest 132. https://doi.org/10.1172/JCI150101
Li Z, Delaney MK, O'Brien KA, Du X (2010) Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol 30:2341–2349. https://doi.org/10.1161/ATVBAHA.110.207522
Article CAS PubMed PubMed Central Google Scholar
Litvinov RI, Farrell DH, Weisel JW, Bennett JS (2016) The Platelet Integrin alphaIIbbeta3 Differentially Interacts with Fibrin Versus Fibrinogen. J Biol Chem 291:7858–7867. https://doi.org/10.1074/jbc.M115.706861
Article CAS PubMed PubMed Central Google Scholar
Wang R, Chen Y, Tian Z, Zhu M, Zhang B, Du S, Li Y, Liu Z, Hou S, Yang Y (2022) Coenzyme Q10 Attenuates Human Platelet Aggregation Induced by SARS-CoV-2 Spike Protein via Reducing Oxidative Stress In Vitro. Int J Mol Sci 23. https://doi.org/10.3390/ijms232012345
Senis YA, Mazharian A, Mori J (2014) Src family kinases: at the forefront of platelet activation. Blood 124:2013–2024. https://doi.org/10.1182/blood-2014-01-453134
Article CAS PubMed PubMed Central Google Scholar
Severin S, Nash CA, Mori J, Zhao Y, Abram C, Lowell CA, Senis YA, Watson SP (2012) Distinct and overlapping functional roles of Src family kinases in mouse platelets. J Thromb Haemost 10:1631–1645. https://doi.org/10.1111/j.1538-7836.2012.04814.x
Article CAS PubMed PubMed Central Google Scholar
Zhang S, Liu Y, Wang X, Yang L, Li H, Wang Y, Liu M, Zhao X, Xie Y, Yang Y, Zhang S, Fan Z, Dong J, Yuan Z, Ding Z, Zhang Y, Hu L (2020) SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. J Hematol Oncol 13:120. https://doi.org/10.1186/s13045-020-00954-7
Article CAS PubMed PubMed Central Google Scholar
Jackson SP (2007) The growing complexity of platelet aggregation. Blood 109:5087–5095. https://doi.org/10.1182/blood-2006-12-027698
Article CAS PubMed Google Scholar
Takada Y, Ye X, Simon S (2007) The integrins. Genome Biol 8:215. https://doi.org/10.1186/gb-2007-8-5-215
Article CAS PubMed PubMed Central Google Scholar
Shattil SJ, Kashiwagi H, Pampori N (1998) Integrin signaling: the platelet paradigm. Blood 91:2645–2657
Article CAS PubMed Google Scholar
Weiss LJ, Drayss M, Manukjan G, Zeitlhöefler MJ, Kleiss J, Weigel ML, Herrmann J, Mott K, Beck S, Burkard P, Lam TT, Althaus K, Bakchoul T, Frantz S, Meybohm P, Nieswandt B, Weismann D, Schulze H (2022) Uncoupling of platelet granule release and integrin activation suggests GPIIb/IIIa as therapeutic target in COVID-19. Blood Adv. https://doi.org/10.1182/bloodadvances.2022008666
Hughan SC, Hughes CE, McCarty OJT, Schweighoffer E, Soultanova I, Ware J, Tybulewicz VLJ, Watson SP (2007) GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arterioscl Throm Vas 27:422–429. https://doi.org/10.1161/01.Atv.0000252826.96134.21
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