Adio A (2009) (-)-trans-β-Elemene and related compounds: occurrence, synthesis, and anticancer activity. Tetrahedron 65:5145–5159. https://doi.org/10.1016/j.tet.2009.04.062
Aggarwal BB, Vijayalekshmi RV, Sung B (2009) Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res: J Am Assoc Cancer Res 15(2):425–430. https://doi.org/10.1158/1078-0432.ccr-08-0149
Arendt P, Miettinen K, Pollier J, De Rycke R, Callewaert N, Goossens A (2017) An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids. Metab Eng 40:165–175. https://doi.org/10.1016/j.ymben.2017.02.007
Article CAS PubMed Google Scholar
Assar EA, Vidalle MC, Chopra M, Hafizi S (2016) Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells. Tumour Biol: J Int Soc Oncodevelop Biol Med 37(7):9375–9385. https://doi.org/10.1007/s13277-016-4798-3
Babaei G, Aliarab A, Abroon S, Rasmi Y, Aziz SG-G (2018) Application of sesquiterpene lactone: a new promising way for cancer therapy based on anticancer activity. Biomed Pharmacother 106:239–246. https://doi.org/10.1016/j.biopha.2018.06.131
Article CAS PubMed Google Scholar
Barrero AF, Herrador MM, López-Pérez JL, Arteaga JF, Catalán J (2009) New pathways in transannular cyclization of germacrone [germacra-1(10),4,7(11)-trien-8-one]: evidence regarding a concerted mechanism. Org Lett 11(21):4782–4785. https://doi.org/10.1021/ol901066x
Article CAS PubMed Google Scholar
Berger TG, Dieckmann D, Efferth T, Schultz ES, Funk JO, Baur A, Schuler G (2005) Artesunate in the treatment of metastatic uveal melanoma–first experiences. Oncol Rep 14(6):1599–1603
Berini F, Casciello C, Marcone GL, Marinelli F (2017) Metagenomics: novel enzymes from non-culturable microbes. FEMS Microbiol Lett 364(21). https://doi.org/10.1093/femsle/fnx211
Breitmaier E (2006) Terpenes: flavors, fragrances, Pharmaca. Pheromones I-IX. https://doi.org/10.1002/9783527609949.fmatter
Bröker JN, Müller B, Prüfer D, Schulze Gronover C (2020) Combinatorial metabolic engineering in Saccharomyces cerevisiae for the enhanced production of the FPP-Derived sesquiterpene germacrene. Bioeng (Basel Switzerland) 7(4). https://doi.org/10.3390/bioengineering7040135
Bu X, Lin JY, Duan CQ, Koffas MAG, Yan GL (2022) Dual regulation of lipid droplet-triacylglycerol metabolism and ERG9 expression for improved β-carotene production in Saccharomyces cerevisiae. Microb Cell Fact 21(1):3. https://doi.org/10.1186/s12934-021-01723-y
Article CAS PubMed PubMed Central Google Scholar
Castro TS, Martins GF, de Alcântara Morais SF, Ferreira DAC (2023) Aromaticity of Cope and Claisen rearrangements. Theor Chem Acc 142(5):40. https://doi.org/10.1007/s00214-023-02975-0
Chadwick M, Trewin H, Gawthrop F, Wagstaff C (2013) Sesquiterpenoids lactones: benefits to plants and people. Int J Mol Sci 14(6):12780–12805. https://doi.org/10.3390/ijms140612780
Article CAS PubMed PubMed Central Google Scholar
Chakraborty S, Ásgeirsson B, Rao BJ (2012) A measure of the broad substrate specificity of enzymes based on ‘Duplicate’ Catalytic residues. PLoS ONE 7(11):e49313. https://doi.org/10.1371/journal.pone.0049313
Article CAS PubMed PubMed Central Google Scholar
Chen R, Liu Y, Chen S, Wang M, Zhu Y, Hu T, Wei Q, Yin X, Xie T (2022) Protein engineering of a germacrene a synthase from Lactuca sativa and its application in high productivity of germacrene A in Escherichia coli. Front Plant Sci 13:932966. https://doi.org/10.3389/fpls.2022.932966
Article PubMed PubMed Central Google Scholar
Cheng J, Miller B, Balbuena E, Eroglu A (2020) Lycopene protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair. Antioxid (Basel Switzerland) 9(7). https://doi.org/10.3390/antiox9070643
Cheng T, Wang L, Sun C, Xie C (2022) Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli. Microb Cell Fact 21(1):121. https://doi.org/10.1186/s12934-022-01843-z
Article CAS PubMed PubMed Central Google Scholar
Cheng J, Zuo Y, Liu G, Li D, Gao J, Xiao F, Huang L, Xu Z, Lian J (2023) Development of a Pichia pastoris cell factory for efficient production of germacrene A: a precursor of β-elemene. Bioresour Bioprocess 10(1):38. https://doi.org/10.1186/s40643-023-00657-0
Article PubMed PubMed Central Google Scholar
Choi JH, Lee KT (2009) Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation. Biol Pharm Bull 32(10):1803–1808. https://doi.org/10.1248/bpb.32.1803
Article CAS PubMed Google Scholar
Chun J, Li RJ, Cheng MS, Kim YS (2015) Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett 357(1):393–403. https://doi.org/10.1016/j.canlet.2014.11.049
Article CAS PubMed Google Scholar
Cotugno R, Fortunato R, Santoro A, Gallotta D, Braca A, De Tommasi N, Belisario MA (2012) Effect of sesquiterpene lactone coronopilin on leukaemia cell population growth, cell type-specific induction of apoptosis and mitotic catastrophe. Cell Prolif 45(1):53–65. https://doi.org/10.1111/j.1365-2184.2011.00796.x
Article CAS PubMed Google Scholar
Cui M, Wang Z, Hu X, Wang X (2019) Effects of lipopolysaccharide structure on lycopene production in Escherichia coli. Enzyme Microb Technol 124:9–16. https://doi.org/10.1016/j.enzmictec.2019.01.009
Article CAS PubMed PubMed Central Google Scholar
de Kraker J-W, Franssen MCR, de Groot A, König WA, Bouwmeester HJ (1998a) (+)-Germacrene A biosynthesis: the committed step in the biosynthesis of bitter sesquiterpene lactones in chicory. Plant Physiol 117(4):1381–1392. https://doi.org/10.1104/pp.117.4.1381
Article PubMed Central Google Scholar
de Kraker JW, Franssen MC, de Groot A, Konig WA, Bouwmeester HJ (1998b) (+)-Germacrene A biosynthesis. The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory. Plant Physiol 117(4):1381–1392. https://doi.org/10.1104/pp.117.4.1381
Article PubMed Central Google Scholar
de Kraker JW, Franssen MC, de Groot A, Shibata T, Bouwmeester HJ (2001) Germacrenes from fresh costus roots. Phytochemistry 58(3):481–487. https://doi.org/10.1016/s0031-9422(01)00291-6
de Kraker J-W, Franssen MCR, Joerink M, de Groot A, Bouwmeester HJ (2002) Biosynthesis of Costunolide, Dihydrocostunolide, and Leucodin. Demonstration of cytochrome P450-Catalyzed formation of the Lactone Ring Present in Sesquiterpene Lactones of Chicory. Plant Physiol 129(1):257–268. https://doi.org/10.1104/pp.010957
Article CAS PubMed PubMed Central Google Scholar
Degenhardt J, Köllner TG, Gershenzon J (2009) Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants. Phytochemistry 70(15):1621–1637. https://doi.org/10.1016/j.phytochem.2009.07.030
Article CAS PubMed Google Scholar
Denmeade SR, Isaacs JT (2005) The SERCA pump as a therapeutic target: making a smart bomb for prostate cancer. Cancer Biol Ther 4(1):14–22. https://doi.org/10.4161/cbt.4.1.1505
Dey S, Sarkar M, Giri B (2016) Anti-inflammatory and anti-tumor activities of parthenolide: an update. J Chem Biol Ther 1(2):107
Dueber JE, Wu GC, Malmirchegini GR, Moon TS, Petzold CJ, Ullal AV, Prather KLJ, Keasling JD (2009) Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol 27(8):753–759. https://doi.org/10.1038/nbt.1557
Article CAS PubMed Google Scholar
Durairaj J, Melillo E, Bouwmeester HJ, Beekwilder J, de Ridder D, van Dijk ADJ (2021) Integrating structure-based machine learning and co-evolution to investigate specificity in plant sesquiterpene synthases. PLoS Comput Biol 17(3):e1008197. https://doi.org/10.1371/journal.pcbi.1008197
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