Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro Oncol. 2021;23:iii1–105. https://doi.org/10.1093/neuonc/noab200.

Article  PubMed  PubMed Central  Google Scholar 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987–96.

Article  CAS  PubMed  Google Scholar 

Kelly C, Majewska P, Ioannidis S, Raza MH, Williams M. Estimating progression-free survival in patients with glioblastoma using routinely collected data. J Neurooncol. 2017;135:621–7. https://doi.org/10.1007/s11060-017-2619-1.

Article  PubMed  PubMed Central  Google Scholar 

Tang X, Zuo C, Fang P, Liu G, Qiu Y, Huang Y, et al. Targeting glioblastoma stem cells: a review on biomarkers, signal pathways and targeted therapy. Front Oncol. 2021;11:701291. https://doi.org/10.3389/fonc.2021.701291.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodriguez SMB, Staicu G-A, Sevastre A-S, Baloi C, Ciubotaru V, Dricu A, et al. Glioblastoma stem cells—useful tools in the battle against cancer. Int J Mol Sci. 2022;23:4602.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosińska S, Gavard J. Tumor vessels fuel the fire in glioblastoma. Int J Mol Sci. 2021;22:6514.

Article  PubMed  PubMed Central  Google Scholar 

Sperb N, Tsesmelis M, Wirth T. Crosstalk between tumor and stromal cells in pancreatic ductal adenocarcinoma. Int J Mol Sci. 2020;21:5486.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elmslie RE, Dow SW, Ogilvie GK. Interleukins: biological properties and therapeutic potential. J Vet Intern Med. 1991;5:283–93. https://doi.org/10.1111/j.1939-1676.1991.tb03135.x.

Article  CAS  PubMed  Google Scholar 

Wang B, Zhao C-H, Sun G, Zhang Z-W, Qian B-M, Zhu Y-F, et al. IL-17 induces the proliferation and migration of glioma cells through the activation of PI3K/Akt1/NF-κB-p65. Cancer Lett. 2019;447:93–104.

Article  CAS  PubMed  Google Scholar 

Borowczak J, Szczerbowski K, Maniewski M, Kowalewski A, Janiczek-Polewska M, Szylberg A, et al. The role of inflammatory cytokines in the pathogenesis of colorectal carcinoma—recent findings and review. Biomedicines. 2022;10:1670.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Do Thi VA, Park SM, Lee H, Kim YS. The membrane-bound form of IL-17A promotes the growth and tumorigenicity of colon cancer cells. Mol Cells. 2016;39:536–42. https://doi.org/10.14348/molcells.2016.0048.

Article  CAS  PubMed  Google Scholar 

Wu H-H, Hwang-Verslues WW, Lee W-H, Huang C-K, Wei P-C, Chen C-L, et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med. 2015;212:333–49. https://doi.org/10.1084/jem.20141702.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaffen SL. Recent advances in the IL-17 cytokine family. Curr Opin Immunol. 2011;23:613–9. https://doi.org/10.1016/j.coi.2011.07.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, et al. Differential regulation of chemokines by IL-17 in colonic epithelial cells. J Immunol. 2008;181:6536–45. https://doi.org/10.4049/jimmunol.181.9.6536.

Article  CAS  PubMed  Google Scholar 

Zheng Q, Diao S, Wang Q, Zhu C, Sun X, Yin B, et al. IL-17A promotes cell migration and invasion of glioblastoma cells via activation of PI3K/AKT signalling pathway. J Cell Mol Med. 2019;23:357–69. https://doi.org/10.1111/jcmm.13938.

Article  CAS  PubMed  Google Scholar 

Kong Y, Ai C, Dong F, Xia X, Zhao X, Yang C, et al. Targeting of BMI-1 with PTC-209 inhibits glioblastoma development. Cell Cycle. 2018;17:1199–211. https://doi.org/10.1080/15384101.2018.1469872.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng Y, Wang J, Tan D, Cheng P, Wu A. Relationship between circulating inflammatory factors and glioma risk and prognosis: a meta-analysis. Cancer Med. 2019;8:7454–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bender DE, Schaettler MO, Sheehan KC, Johanns TM, Dunn GP. Cytokine profiling in plasma from patients with brain tumors versus healthy individuals using 2 different multiplex immunoassay platforms. Biomark Insights. 2021;16:11772719211006666.

Article  PubMed  PubMed Central  Google Scholar 

Madkouri R, Kaderbhai CG, Bertaut A, Truntzer C, Vincent J, Aubriot-Lorton MH, et al. Immune classifications with cytotoxic CD8+ and Th17 infiltrates are predictors of clinical prognosis in glioblastoma. Oncoimmunology. 2017;6:e1321186.

Article  PubMed  PubMed Central  Google Scholar 

Cui X, Xu Z, Zhao Z, Sui D, Ren X, Huang Q, et al. Analysis of CD137L and IL-17 expression in tumor tissue as prognostic indicators for gliblastoma. Int J Biol Sci. 2013;9:134–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fabre J, Giustiniani J, Garbar C, Antonicelli F, Merrouche Y, Bensussan A, et al. Targeting the tumor microenvironment: the protumor effects of IL-17 related to cancer type. Int J Mol Sci. 2016;17:1433.

Article  PubMed  PubMed Central  Google Scholar 

Amatya N, Garg AV, Gaffen SL. IL-17 signaling: the Yin and the Yang. Trends Immunol. 2017;38:310–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge Y, Huang M, Yao Y. Biology of interleukin-17 and Its pathophysiological significance in sepsis. Front Immunol. 2020. https://doi.org/10.3389/fimmu.2020.01558.

Article  PubMed  PubMed Central  Google Scholar 

Milovanovic J, Arsenijevic A, Stojanovic B, Kanjevac T, Arsenijevic D, Radosavljevic G, et al. Interleukin-17 in chronic inflammatory neurological diseases. Front Immunol. 2020;11:947.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235–8. https://doi.org/10.1038/nature04753.

Article  CAS  PubMed  Google Scholar 

Castro G, Liu X, Ngo K, De Leon-Tabaldo A, Zhao S, Luna-Roman R, et al. RORγt and RORα signature genes in human Th17 cells. PLoS ONE. 2017;12:e0181868.

Article  PubMed  PubMed Central  Google Scholar 

McGeachy MJ, Cua DJ, Gaffen SL. The IL-17 family of cytokines in health and disease. Immunity. 2019;50:892–906. https://doi.org/10.1016/j.immuni.2019.03.021.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui G, Yuan A, Goll R, Florholmen J. IL-17A in the tumor microenvironment of the human colorectal adenoma-carcinoma sequence. Scand J Gastroenterol. 2012;47:1304–12.